دورية أكاديمية
أعرض في EDS

Nanoemulsion of Sideroxylon obtusifolium as an Alternative to Combat Schistosomiasis.

التفاصيل البيبلوغرافية
العنوان: Nanoemulsion of Sideroxylon obtusifolium as an Alternative to Combat Schistosomiasis.
المؤلفون: Rangel LDS; Laboratório de Avaliação e Promoção da Saúde Ambiental, Instituto Oswaldo Cruz - Fiocruz, Rio de Janeiro, Brazil.; Programa de Pós-Graduação em Ciências e Biotecnologia, Universidade Federal Fluminense, Niterói, Brazil., Passos de Oliveira A; Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Falcão DQ; Laboratório de Tecnologia de Produtos Naturais, Universidade Federal Fluminense, Niterói, Brazil., Santos MG; Departamento de Ciências, Faculdade de Formação de Professores, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil., Von Ranke NL; Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Rodrigues CR; Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Dos Santos JAA; Laboratório de Avaliação e Promoção da Saúde Ambiental, Instituto Oswaldo Cruz - Fiocruz, Rio de Janeiro, Brazil., Rocha L; Laboratório de Tecnologia de Produtos Naturais, Universidade Federal Fluminense, Niterói, Brazil., Faria RX; Laboratório de Avaliação e Promoção da Saúde Ambiental, Instituto Oswaldo Cruz - Fiocruz, Rio de Janeiro, Brazil.; Programa de Pós-Graduação em Ciências e Biotecnologia, Universidade Federal Fluminense, Niterói, Brazil.
المصدر: Frontiers in plant science [Front Plant Sci] 2022 May 26; Vol. 13, pp. 853002. Date of Electronic Publication: 2022 May 26 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101568200 Publication Model: eCollection Cited Medium: Print ISSN: 1664-462X (Print) Linking ISSN: 1664462X NLM ISO Abbreviation: Front Plant Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Research Foundation, 2010-
مستخلص: Schistosomiasis is caused by the intestinal parasite Schistosoma mansoni . Individuals are affected by schistosomiasis when they are exposed to aquatic environments contaminated with Schistosoma cercariae that emerged from the infected intermediate host mollusk of the genus Biomphalaria . The WHO recommends using molluscicidal products to reduce the snail population and disease transmission. The WHO encourages the search for alternative substances in schistosomiasis control. Natural products are seen as a promising alternative because they are abundant in countries where schistosomiasis is endemic and have many different substances in their extracts, impairing cases of resistance. Therefore, the nanoemulsion effect of a butanol-soluble fraction of Sideroxylon obtusifolium leaves was evaluated against three study points in the biological cycle of the disease, that is, adults and young Biomphalaria glabrata , spawning by the host mollusk, and infectious larvae of the parasite. Extract-SOB (butanol fraction) and nano-SOB (nanoemulsion) demonstrated promising activity in adult B. glabrata population control with an LC 50 of 125.4 mg/L, an LC 90 of 178.1 mg/L, an LC 50 of 75.2 mg/L, and an LC 90 of 97 mg/L. Nano-SOB presented greater potency against young B. glabrata , with an LC 90 of 72.1 mg/L and an LC 50 of 58.3 mg/L. Still, relevant activity against S. mansoni cercariae was eliminated in 4 h (LC 90 : 34.6 mg/L). Nano-SOB reduced viable spawning by approximately 30% at 178.1 and 97 mg/L. Referring to most substances in this extract, quercetin-3-rhamnosyl-(1-6)-galactoside and hyperoside may cause low environmental toxicity and human toxicity according to in silico analysis. Thus, nano-SOB is a promising agent to combat B. glabrata population growth and schistosomiasis transmission.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Rangel, Passos de Oliveira, Falcão, Santos, Von Ranke, Rodrigues, Santos, Rocha and Faria.)
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فهرسة مساهمة: Keywords: Biomphalaria; Sideroxylon obtusifolium; molluscicide; nanoemulsion; plant extract
تواريخ الأحداث: Date Created: 20220613 Latest Revision: 20231102
رمز التحديث: 20231102
مُعرف محوري في PubMed: PMC9178252
DOI: 10.3389/fpls.2022.853002
PMID: 35693155
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-462X
DOI:10.3389/fpls.2022.853002