دورية أكاديمية
أعرض في EDS

Effect of physical training on cytokine expression in CD4+ T lymphocytes in subjects with stable COPD.

التفاصيل البيبلوغرافية
العنوان: Effect of physical training on cytokine expression in CD4+ T lymphocytes in subjects with stable COPD.
المؤلفون: Uzeloto JS; Department of Physiotherapy, Postgraduate Program in Physiotherapy, Faculty of Science and Technology, São Paulo State University (UNESP), Rua Roberto Simonsen, 305, Presidente Prudente, São Paulo 19060-900, Brazil., de Toledo-Arruda AC; Department of Physiology and Pharmacology, Laboratory of Exercise Sciences, Fluminense Federal University, Rio de Janeiro, Brazil., Silva BSA; Physiotherapy, Universidade Estadual Paulista Julio de Mesquita Filho, Presidente Prudente., Braz AMM; Universidade Estadual Paulista Julio de Mesquita Filho.; Instituto de Biociencias Campus de Botucatu, Medical Biotechnology, Botucatu., de Lima FF; Physiotherapy, Universidade Estadual Paulista Julio de Mesquita Filho, Presidente Prudente., Grigoletto I; Physiotherapy, Universidade Estadual Paulista Julio de Mesquita Filho, Presidente Prudente., Ramos D; Physiotherapy, Universidade Estadual Paulista Julio de Mesquita Filho, Presidente Prudente., Golim MA; Botucatu Medical School, Postgraduate Program in Research & Development: Medical Biotechnology, Blood Center, Flow Cytometry Laboratory, São Paulo State University (UNESP), São Paulo, Brazil., Ramos EMC; Physiotherapy, Universidade Estadual Paulista Julio de Mesquita Filho, Presidente Prudente.
المصدر: Therapeutic advances in respiratory disease [Ther Adv Respir Dis] 2022 Jan-Dec; Vol. 16, pp. 17534666221091179.
نوع المنشور: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: SAGE Publications Country of Publication: England NLM ID: 101316317 Publication Model: Print Cited Medium: Internet ISSN: 1753-4666 (Electronic) Linking ISSN: 17534658 NLM ISO Abbreviation: Ther Adv Respir Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London, UK : SAGE Publications
مواضيع طبية MeSH: Cytokines*/metabolism , Pulmonary Disease, Chronic Obstructive*/diagnosis , Pulmonary Disease, Chronic Obstructive*/metabolism , Pulmonary Disease, Chronic Obstructive*/therapy, Aged ; CD4-Positive T-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/pathology ; Exercise ; Humans ; Interleukin-13 ; Interleukin-8 ; Middle Aged ; Tumor Necrosis Factor-alpha
مستخلص: Introduction: Although evidence suggests that physical exercise reduces systemic inflammation, at the plasma level, there are still contradictions in chronic obstructive pulmonary disease (COPD). In this sense, analysis of intracellular cytokines could clear off the effect of physical exercise on the inflammatory profile of these subjects.
Aim: The aim was to evaluate the effect of physical training on cytokine expression in CD4+ T lymphocytes from subjects with COPD.
Methods: This is a randomized controlled trial. Subjects with stable COPD were grouped into two groups, exercise and control. In total, 23 subjects with stable COPD were evaluated, of which 15 underwent aerobic strength training [physical exercise group (PEG)] and 8 underwent breathing exercises [respiratory physiotherapy group (RPG)]. Intracellular cytokines [interleukin (IL)-8, IL-13, IL-17, IL-6, IL-2, IL-10, and tumor necrosis factor alpha (TNF-α)] from CD4+ T lymphocytes were analyzed from peripheral blood through flow cytometry, before and after 8 weeks of intervention.
Results: The PEG and RPG groups had a mean age of 68 ± 5.96 and 72.25 ± 6.86 years and predicted forced expiratory volume in the first second (FEV 1 ) of 58.6 ± 15.99% and 39.75 ± 10.39%, respectively. It was possible to detect a significant reduction in IL-8 ( p  = 0.0125) and an increase in IL-13 ( p  = 0.0014) and an increase in TNF-α ( p  < 0.001) in both groups.
Conclusion: Eight weeks of physical training, both peripheral and respiratory, were able to reduce concentrations of IL-8 and to increase IL-13, and TNF-α in CD4+ T lymphocytes in subjects with stable COPD. The findings reinforce the benefits of interventions in subjects with COPD, revealing data not previously investigated.
التعليقات: Erratum in: Ther Adv Respir Dis. 2022 Jan-Dec;16:17534666221115274. (PMID: 35822828)
References: Thorax. 2007 Nov;62(11):950-6. (PMID: 17573449)
Respir Physiol Neurobiol. 2017 Aug;242:89-95. (PMID: 28435027)
Science. 2020 May 1;368(6490):. (PMID: 32355002)
Chron Respir Dis. 2016 Aug;13(3):297-311. (PMID: 27056059)
Curr Pharm Des. 2020;26(9):979-990. (PMID: 32133958)
Eur Respir J. 2005 Aug;26(2):319-38. (PMID: 16055882)
Niger J Clin Pract. 2020 Jun;23(6):817-824. (PMID: 32525117)
J Physiol. 2020 Feb;598(3):599-610. (PMID: 31856306)
Respiration. 2010;79(2):160-74. (PMID: 19672044)
Cell Biochem Biophys. 2005;43(1):167-88. (PMID: 16043892)
Thorax. 2003 Sep;58(9):752-6. (PMID: 12947130)
J Bras Pneumol. 2008 Dec;34(12):1008-18. (PMID: 19180335)
Nat Rev Immunol. 2011 Aug 05;11(9):607-15. (PMID: 21818123)
Scand J Med Sci Sports. 2015 Dec;25 Suppl 3:1-72. (PMID: 26606383)
Int J Chron Obstruct Pulmon Dis. 2008;3(4):531-41. (PMID: 19281072)
Eur Respir J. 2014 Dec;44(6):1428-46. (PMID: 25359355)
Front Physiol. 2018 Mar 23;9:262. (PMID: 29628896)
Clin Rehabil. 2014 Nov;28(11):1096-106. (PMID: 24647863)
Med Hypotheses. 2007;68(2):291-8. (PMID: 17010529)
Scand J Med Sci Sports. 2008 Oct;18(5):557-64. (PMID: 18067517)
J Bras Pneumol. 2009 Aug;35(8):737-44. (PMID: 19750325)
Int J Chron Obstruct Pulmon Dis. 2020 Nov 13;15:2931-2940. (PMID: 33223825)
Mediators Inflamm. 2020 Jul 12;2020:4652898. (PMID: 32733164)
Malawi Med J. 2012 Sep;24(3):69-71. (PMID: 23638278)
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004 Oct;26(5):595-9. (PMID: 15562780)
Braz J Phys Ther. 2016 Apr 8;20(3):223-30. (PMID: 27437713)
Ann Am Thorac Soc. 2018 Dec;15(Suppl 4):S234-S238. (PMID: 30758998)
J Bras Pneumol. 2008 Mar;34(3):143-51. (PMID: 18392462)
Health Qual Life Outcomes. 2003 Apr 28;1:13. (PMID: 12773199)
Curr Protoc Immunol. 2015 Aug 03;110:6.24.1-6.24.18. (PMID: 26237012)
PLoS One. 2016 Apr 22;11(4):e0150586. (PMID: 27104349)
Cochrane Database Syst Rev. 2015 Feb 23;(2):CD003793. (PMID: 25705944)
Thorax. 2007 Feb;62(2):109-14. (PMID: 16928709)
Phys Ther. 2016 Nov;96(11):1807-1815. (PMID: 27081201)
Am J Respir Crit Care Med. 2015 Jun 1;191(11):1232-41. (PMID: 25844618)
Scand J Med Sci Sports. 2018 Nov;28(11):2339-2348. (PMID: 29802649)
Am J Respir Crit Care Med. 2015 Jun 1;191(11):1213-4. (PMID: 26029829)
Clin Chest Med. 2020 Sep;41(3):421-438. (PMID: 32800196)
Int J Chron Obstruct Pulmon Dis. 2015 Mar 23;10:645-53. (PMID: 25848241)
Diabetes Obes Metab. 2013 Sep;15 Suppl 3:51-60. (PMID: 24003921)
BMC Pulm Med. 2014 Aug 30;14:142. (PMID: 25175787)
Pathol Res Pract. 2019 Jan;215(1):97-105. (PMID: 30392917)
Trials. 2019 Dec 5;20(1):680. (PMID: 31805981)
Analyst. 2020 Mar 2;145(5):1583-1604. (PMID: 31915768)
Int J Chron Obstruct Pulmon Dis. 2007;2(3):347-53. (PMID: 18229573)
Am J Respir Crit Care Med. 2011 Apr 15;183(8):977-86. (PMID: 21097694)
Braz J Med Biol Res. 1999 Jun;32(6):703-17. (PMID: 10412549)
Cochrane Database Syst Rev. 2012 Oct 17;10:CD008250. (PMID: 23076942)
Respir Res. 2007 Sep 14;8:64. (PMID: 17868461)
فهرسة مساهمة: Keywords: chronic obstructive pulmonary disease; flow cytometry; inflammation; physical exercise
المشرفين على المادة: 0 (Cytokines)
0 (Interleukin-13)
0 (Interleukin-8)
0 (Tumor Necrosis Factor-alpha)
تواريخ الأحداث: Date Created: 20220613 Date Completed: 20220614 Latest Revision: 20220716
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9189509
DOI: 10.1177/17534666221091179
PMID: 35695009
قاعدة البيانات: MEDLINE
الوصف
تدمد:1753-4666
DOI:10.1177/17534666221091179