دورية أكاديمية
MicroRNA-9-3p: a novel predictor of neurological outcome after cardiac arrest.
| العنوان: | MicroRNA-9-3p: a novel predictor of neurological outcome after cardiac arrest. |
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| المؤلفون: | Beske RP; Department of Cardiology, The Heart Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Bache S; Department of Neuroanaesthesiology, The Neuroscience Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Centre for Genomic Medicine, Rigshospitalet, Copenhagen, Denmark., Abild Stengaard Meyer M; Department of Cardiology, The Heart Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Kjærgaard J; Department of Cardiology, The Heart Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Bro-Jeppesen J; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark., Obling L; Department of Cardiology, The Heart Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Olsen MH; Department of Neuroanaesthesiology, The Neuroscience Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Rossing M; Centre for Genomic Medicine, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen: Copenhagen, Denmark., Nielsen FC; Centre for Genomic Medicine, Rigshospitalet, Copenhagen, Denmark., Møller K; Department of Neuroanaesthesiology, The Neuroscience Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen: Copenhagen, Denmark., Nielsen N; Department of Clinical Sciences at Helsingborg, Lund University, Lund, Sweden., Hassager C; Department of Cardiology, The Heart Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark. |
| المصدر: | European heart journal. Acute cardiovascular care [Eur Heart J Acute Cardiovasc Care] 2022 Aug 09; Vol. 11 (8), pp. 609-616. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101591369 Publication Model: Print Cited Medium: Internet ISSN: 2048-8734 (Electronic) Linking ISSN: 20488726 NLM ISO Abbreviation: Eur Heart J Acute Cardiovasc Care Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : [Oxford] : Oxford University Press Original Publication: London : SAGE Publications, 2012- |
| مواضيع طبية MeSH: | Hypothermia, Induced*/methods , MicroRNAs*/genetics , Out-of-Hospital Cardiac Arrest*/complications, Biomarkers ; Coma/complications ; Coma/genetics ; Humans ; Prognosis |
| مستخلص: | Aims: Resuscitated out-of-hospital cardiac arrest (OHCA) patients who remain comatose after hospital arrival are at high risk of mortality due to anoxic brain injury. MicroRNA are small-non-coding RNA molecules ultimately involved in gene-silencing. They show promise as biomarkers, as they are stable in body fluids. The microRNA 9-3p (miR-9-3p) is associated with neurological injury in trauma and subarachnoid haemorrhage. Methods and Results: This post hoc analysis considered all 171 comatose OHCA patients from a single centre in the target temperature management (TTM) trial. Patients were randomized to TTM at either 33°C or 36°C for 24 h. MicroRNA-9-3p (miR-9-3p) was measured in plasma sampled at admission and at 28, 48, and 72 h. There were no significant differences in age, gender, and pre-hospital data, including lactate level at admission, between miR-9-3p level quartiles. miR-9-3p levels changed markedly following OHCA with a peak at 48 h. Median miR-9-3p levels between TTM 33°C vs. 36°C were not different at any of the four time points. Elevated miR-9-3p levels at 48 h were strongly associated with an unfavourable neurological outcome [OR: 2.21, 95% confidence interval (CI): 1.64-3.15, P < 0.0001). MiR-9-3p was inferior to neuron-specific enolase in predicting functional neurological outcome [area under the curve: 0.79 (95% CI: 0.71-0.87) vs. 0.91 (95% CI: 0.85-0.97)]. Conclusion: MiR-9-3p is strongly associated with neurological outcome following OHCA, and the levels of miR-9-3p are peaking 48 hours following cardiac arrest. Competing Interests: Conflict of interest: None declared. (© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please email: journals.permissions@oup.com.) |
| التعليقات: | Comment in: Eur Heart J Acute Cardiovasc Care. 2022 Jul 11;:. (PMID: 35816291) |
| فهرسة مساهمة: | Keywords: Cardiac arrest; Microrna; Mir-9-3p; Neurologic outcome; Out-of-hospital cardiac arrest; Prognostication |
| المشرفين على المادة: | 0 (Biomarkers) 0 (MicroRNAs) |
| تواريخ الأحداث: | Date Created: 20220613 Date Completed: 20220811 Latest Revision: 20220822 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1093/ehjacc/zuac066 |
| PMID: | 35695264 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2048-8734 |
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| DOI: | 10.1093/ehjacc/zuac066 |