دورية أكاديمية
أعرض في EDS

Bacterial Strain-Dependent Dissociation of Cell Recruitment and Cell-to-Cell Spread in Early M. tuberculosis Infection.

التفاصيل البيبلوغرافية
العنوان: Bacterial Strain-Dependent Dissociation of Cell Recruitment and Cell-to-Cell Spread in Early M. tuberculosis Infection.
المؤلفون: Zha BS; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, University of California, San Franciscogrid.266102.1, California, USA.; Division of Experimental Medicine, Department of Medicine, University of California, San Franciscogrid.266102.1, California, USA., Desvignes L; Department of Medicine, New York University School of Medicine, New York, New York, USA., Fergus TJ; Department of Medicine, New York University School of Medicine, New York, New York, USA., Cornelius A; Department of Medicine, New York University School of Medicine, New York, New York, USA., Cheng TY; Division of Rheumatology, Immunity and Inflammation, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Moody DB; Division of Rheumatology, Immunity and Inflammation, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Ernst JD; Division of Experimental Medicine, Department of Medicine, University of California, San Franciscogrid.266102.1, California, USA.
المصدر: MBio [mBio] 2022 Jun 28; Vol. 13 (3), pp. e0133222. Date of Electronic Publication: 2022 Jun 13.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, D.C. : American Society for Microbiology
مواضيع طبية MeSH: Mycobacterium tuberculosis* , Tuberculosis*/microbiology, Animals ; Immunity, Innate ; Lung/microbiology ; Macrophages, Alveolar ; Mice
مستخلص: In the initial stage of respiratory infection, Mycobacterium tuberculosis traverses from alveolar macrophages to phenotypically diverse monocyte-derived phagocytes and neutrophils in the lung parenchyma. Here, we compare the in vivo kinetics of early bacterial growth and cell-to-cell spread of two strains of M. tuberculosis: a lineage 2 strain, 4334, and the widely studied lineage 4 strain H37Rv. Using flow cytometry, live cell sorting of phenotypic subsets, and quantitation of bacteria in cells of the distinct subsets, we found that 4334 induces less leukocyte influx into the lungs but demonstrates earlier population expansion and cell-to-cell spread. The earlier spread of 4334 to recruited cells, including monocyte-derived dendritic cells, is accompanied by earlier and greater magnitude of CD4 + T cell activation. The results provide evidence that strain-specific differences in interactions with lung leukocytes can shape adaptive immune responses in vivo . IMPORTANCE Tuberculosis is a leading infectious disease killer worldwide and is caused by Mycobacterium tuberculosis. After exposure to M. tuberculosis, outcomes range from apparent elimination to active disease. Early innate immune responses may contribute to differences in outcomes, yet it is not known how bacterial strains alter the early dynamics of innate immune and T cell responses. We infected mice with distinct strains of M. tuberculosis and discovered striking differences in innate cellular recruitment, cell-to-cell spread of bacteria in the lungs, and kinetics of initiation of antigen-specific CD4 T cell responses. We also found that M. tuberculosis can spread beyond alveolar macrophages even before a large influx of inflammatory cells. These results provide evidence that distinct strains of M. tuberculosis can exhibit differential kinetics in cell-to-cell spread which is not directly linked to early recruitment of phagocytes but is subsequently linked to adaptive immune responses.
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معلومات مُعتمدة: P30 CA016087 United States CA NCI NIH HHS; K08 HL163405 United States HL NHLBI NIH HHS; R01 AI051242 United States AI NIAID NIH HHS; R01 AI165573 United States AI NIAID NIH HHS; R01 AI049313 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Beijing strain; Mycobacterium tuberculosis; T cell activation; T cell priming; dendritic cells; innate immunity; innate response; macrophage; strain diversity; tuberculosis
تواريخ الأحداث: Date Created: 20220613 Date Completed: 20220630 Latest Revision: 20240327
رمز التحديث: 20240327
مُعرف محوري في PubMed: PMC9239178
DOI: 10.1128/mbio.01332-22
PMID: 35695454
قاعدة البيانات: MEDLINE
الوصف
تدمد:2150-7511
DOI:10.1128/mbio.01332-22