دورية أكاديمية
أعرض في EDS

EGFL7 expression profile in IDH-wildtype glioblastomas is associated with poor patient outcome.

التفاصيل البيبلوغرافية
العنوان: EGFL7 expression profile in IDH-wildtype glioblastomas is associated with poor patient outcome.
المؤلفون: da Costa BHB; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.; Barretos School of Health Sciences, Dr. Paulo Prata - FACISB, Barretos, São Paulo, Brazil., Becker AP; The Ohio State University, Department of Radiation Oncology, Columbus, OH, USA., Neder L; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.; Department of Pathology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirão Preto, Sao Paulo, Brazil., Gonçalves PG; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.; UNESP - Univ. Estadual Paulista, School of Medicine, Department of Pathology, Botucatu, São Paulo, Brazil., de Oliveira C; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.; UNESP - Univ. Estadual Paulista, School of Medicine, Department of Pathology, Botucatu, São Paulo, Brazil., Polverini AD; Department of Neurosurgery, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Clara CA; Department of Neurosurgery, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Teixeira GR; Barretos School of Health Sciences, Dr. Paulo Prata - FACISB, Barretos, São Paulo, Brazil.; Department of Pathology, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Reis RM; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal., Bidinotto LT; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.; Barretos School of Health Sciences, Dr. Paulo Prata - FACISB, Barretos, São Paulo, Brazil.; UNESP - Univ. Estadual Paulista, School of Medicine, Department of Pathology, Botucatu, São Paulo, Brazil.
المصدر: Journal of pathology and translational medicine [J Pathol Transl Med] 2022 Jul; Vol. 56 (4), pp. 205-211. Date of Electronic Publication: 2022 Jun 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Korean Society of Pathologists/Korean Society of Cytopathology Country of Publication: Korea (South) NLM ID: 101650151 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2383-7837 (Print) Linking ISSN: 23837837 NLM ISO Abbreviation: J Pathol Transl Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Seoul : Korean Society of Pathologists/Korean Society of Cytopathology, [2015]-
مستخلص: Background: Despite the advances in glioblastoma (GBM) treatment, the average life span of patients is 14 months. Therefore, it is urgent to identity biomarkers of prognosis, treatment response, or development of novel treatment strategies. We previously described the association of high epidermal growth factor-like domain multiple 7 (EGFL7) expression and unfavorable outcome of pilocytic astrocytoma patients. The present study aims to analyze the prognostic potential of EGFL7 in GBM isocitrate dehydrogenase (IDH)-wildtype, using immunohistochemistry and in silico approaches.
Methods: Spearman's correlation analysis of The Cancer Genome Atlas RNA sequencing data was performed. The genes strongly correlated to EGFL7 expression were submitted to enrichment gene ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Additionally, EGFL7 expression was associated with patient overall survival. The expression of EGFL7 was analyzed through immunohistochemistry in 74 GBM IDH-wildtype patients' samples, and was associated with clinicopathological data and overall survival.
Results: In silico analysis found 78 genes strongly correlated to EGFL7 expression. These genes were enriched in 40 biological processes and eight KEGG pathways, including angiogenesis/vasculogenesis, cell adhesion, and phosphoinositide 3-kinase-Akt, Notch, and Rap1 signaling pathways. The immunostaining showed high EGFL7 expression in 39 cases (52.7%). High immunolabelling was significantly associated with low Karnofsky Performance Status and poor overall survival. Cox analysis showed that GBMs IDH-wildtype with high EGFL7 expression presented a higher risk of death compared to low expression (hazard ratio, 1.645; 95% confidence interval, 1.021 to 2.650; p = .041).
Conclusions: This study gives insights regarding the genes that are correlated with EGFL7, as well as biological processes and signaling pathways, which should be further investigated in order to elucidate their role in glioblastoma biology.
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معلومات مُعتمدة: 2018/20737-1 The São Paulo Research Foundation; 2017/09749-5 The São Paulo Research Foundation; 2016/21727-4 The São Paulo Research Foundation; 472447/2013-0 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
فهرسة مساهمة: Keywords: EGFL7; Glioblastoma IDH-wildtype; Notch pathway; PI3K-Akt pathway; Rap1 pathway
تواريخ الأحداث: Date Created: 20220614 Latest Revision: 20220731
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9288890
DOI: 10.4132/jptm.2022.04.22
PMID: 35698739
قاعدة البيانات: MEDLINE
الوصف
تدمد:2383-7837
DOI:10.4132/jptm.2022.04.22