دورية أكاديمية
Antimitotic and toxicogenetic action of Stevia urticifolia aerial parts on proliferating vegetal and mammalian cells: in vitro and in vivo traditional and replacement methods.
العنوان: | Antimitotic and toxicogenetic action of Stevia urticifolia aerial parts on proliferating vegetal and mammalian cells: in vitro and in vivo traditional and replacement methods. |
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المؤلفون: | Ferreira PMP; Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piauí, Teresina, Brazil.; Postgraduate Program in Pharmacology, Federal University of Piauí, Teresina, Brazil.; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Brazil., Sousa IJO; Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piauí, Teresina, Brazil.; Postgraduate Program in Pharmacology, Federal University of Piauí, Teresina, Brazil., Machado KN; Department of Chemistry, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Brazil., da Silva Neto LA; Department of Chemistry, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Brazil., de Freitas MM; Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piauí, Teresina, Brazil., Dos Santos IL; Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piauí, Teresina, Brazil.; Postgraduate Program in Pharmacology, Federal University of Piauí, Teresina, Brazil., do Nascimento Rodrigues DC; Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piauí, Teresina, Brazil.; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Brazil., de Sousa RWR; Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piauí, Teresina, Brazil.; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Brazil., Dos Reis AC; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Brazil.; Laboratory of Toxicological Genetics (LapGenic), Department of Biochemistry and Pharmacology, Federal University of Piauí, Teresina, Brazil., do Nascimento MLLB; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Brazil.; Laboratory of Toxicological Genetics (LapGenic), Department of Biochemistry and Pharmacology, Federal University of Piauí, Teresina, Brazil., de Menezes APM; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Brazil.; Laboratory of Toxicological Genetics (LapGenic), Department of Biochemistry and Pharmacology, Federal University of Piauí, Teresina, Brazil., do Nascimento AM; Department of Chemistry, Institute of Exact and Biological Sciences, Federal University of Ouro Preto, Ouro Preto, Brazil., de Oliveira Ferreira JR; Center for Integrative Sciences, State University of Health Sciences of Alagoas Maceió, Brazil., Peron AP; Department of Biodiversity and Nature Conservation, Federal Technological University of Paraná, Campo Mourão, Brazil., de Castro E Sousa JM; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Brazil.; Laboratory of Toxicological Genetics (LapGenic), Department of Biochemistry and Pharmacology, Federal University of Piauí, Teresina, Brazil. |
المصدر: | Journal of toxicology and environmental health. Part A [J Toxicol Environ Health A] 2022 Sep 17; Vol. 85 (18), pp. 750-766. Date of Electronic Publication: 2022 Jun 13. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 100960995 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-7394 (Print) Linking ISSN: 00984108 NLM ISO Abbreviation: J Toxicol Environ Health A Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Washington, D.C. ; London : Taylor & Francis, c1998- |
مواضيع طبية MeSH: | Antimitotic Agents* , Stevia*, Animals ; Antioxidants/pharmacology ; Mammals ; Mice ; Plant Components, Aerial ; Plant Extracts/pharmacology ; Toxicogenetics |
مستخلص: | Stevia urticifolia Thunb. is an underexploited herb possessing bioactive flavonoids, saponins, and terpenoids. The aim of this study was to examine the antiproliferative and toxicogenetic properties of the ethyl acetate extract from Stevia urticifolia aerial parts (EtAcSur) upon Artemia salina , erythrocytes, Allium cepa and sarcoma 180 cells and fibroblasts, as well as in vivo studies on mice to determine systemic, macroscopic, and behavioral alterations and bone marrow chromosomal damage. The assessment using A. salina larvae and mouse blood cells revealed LC |
فهرسة مساهمة: | Keywords: Allium cepa; chemoprevention; genotoxicity; in vivo toxicity; sarcoma 180 |
المشرفين على المادة: | 0 (Antimitotic Agents) 0 (Antioxidants) 0 (Plant Extracts) |
تواريخ الأحداث: | Date Created: 20220614 Date Completed: 20220712 Latest Revision: 20220907 |
رمز التحديث: | 20221213 |
DOI: | 10.1080/15287394.2022.2081640 |
PMID: | 35698798 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1528-7394 |
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DOI: | 10.1080/15287394.2022.2081640 |