دورية أكاديمية
أعرض في EDS

An integrative pan-cancer analysis of molecular characteristics and oncogenic role of mitochondrial creatine kinase 1A (CKMT1A) in human tumors.

التفاصيل البيبلوغرافية
العنوان: An integrative pan-cancer analysis of molecular characteristics and oncogenic role of mitochondrial creatine kinase 1A (CKMT1A) in human tumors.
المؤلفون: Yang M; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-Sen University, No. 66, Gongchang Road, Guangming District, Shenzhen, 518107, China. yangmj7@mail2.sysu.edu.cn., Liu S; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-Sen University, No. 66, Gongchang Road, Guangming District, Shenzhen, 518107, China., Xiong Y; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-Sen University, No. 66, Gongchang Road, Guangming District, Shenzhen, 518107, China., Zhao J; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-Sen University, No. 66, Gongchang Road, Guangming District, Shenzhen, 518107, China., Deng W; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-Sen University, No. 66, Gongchang Road, Guangming District, Shenzhen, 518107, China. dengwb5@mail.sysu.edu.cn.; Jiangxi Deshang Pharmaceutical Co., Ltd., Zhangshu, China. dengwb5@mail.sysu.edu.cn.
المصدر: Scientific reports [Sci Rep] 2022 Jun 15; Vol. 12 (1), pp. 10025. Date of Electronic Publication: 2022 Jun 15.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Carcinoma, Non-Small-Cell Lung*/genetics , Creatine Kinase, Mitochondrial Form*/genetics , Lung Neoplasms*/genetics, Carcinogenesis ; Creatine Kinase ; Humans ; Kaplan-Meier Estimate ; Prognosis
مستخلص: In recent years, several studies have suggested that mitochondrial creatine kinase 1A (CKMT1A) plays a key role in various cancer types. However, there is still a lack of systematic understanding of the contribution of CKMT1A in different types of cancer. Therefore, this study aims to explore the potential role of CKMT1A in human tumors. Firstly, we evaluated the expression level of CKMT1A in 33 types of tumors. Secondly, we used the GEPIA2 and Kaplan-Meier plotter to explore the relationship between CKMT1A expression and survival prognosis. Furthermore, the genetic alterations of CKMT1A were analyzed by the cBioPortal web. In addition, we performed immune infiltration analysis and gene enrichment pathway analysis. CKMT1A was highly expressed in most types of cancers and there was a significant correlation between CKMT1A expression and the prognosis of patients for certain tumors. Non-Small Cell Lung Cancer cases with altered CKMT1A showed a poorer overall survival. CKMT1A expression was negatively correlated with the infiltration of cancer-associated fibroblasts in most tumors. We also found that its expression was negatively associated with CD8 + T-cell infiltration in several tumors. Furthermore, enrichment analysis revealed that "Glycolysis/ Gluconeogenesis" and "metabolic pathways" functions were involved in the functional mechanism of CKMT1A. Taken together, our studies will provide a relatively clear and integrative understanding of the role of CKMT1A across different tumors. All these findings will lay a solid foundation for further molecular assays of CKMT1A in tumorigenesis and provide the rationale for developing novel therapeutic strategies.
(© 2022. The Author(s).)
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المشرفين على المادة: EC 2.7.3.2 (CKMT1A protein, human)
EC 2.7.3.2 (Creatine Kinase)
EC 2.7.3.2 (Creatine Kinase, Mitochondrial Form)
تواريخ الأحداث: Date Created: 20220615 Date Completed: 20220617 Latest Revision: 20220816
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9200842
DOI: 10.1038/s41598-022-14346-z
PMID: 35705641
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-022-14346-z