دورية أكاديمية
أعرض في EDS

DKK3/CKAP4 axis is associated with advanced stage and poorer prognosis in oral cancer.

التفاصيل البيبلوغرافية
العنوان: DKK3/CKAP4 axis is associated with advanced stage and poorer prognosis in oral cancer.
المؤلفون: Katase N; Department of Oral Pathology, Institute of Biomedical Sciences, Nagasaki University, Nagasaki, Japan., Kudo K; Department of Oral Pathology, Institute of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.; Nagasaki University Dental School, Nagasaki, Japan., Ogawa K; Department of Oral Pathology, Institute of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.; Nagasaki University Dental School, Nagasaki, Japan., Sakamoto Y; Department of Oral Pathology, Institute of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.; Nagasaki University Dental School, Nagasaki, Japan., Nishimatsu SI; Department of Natural Sciences, Kawasaki Medical School, Okayama, Japan., Yamauchi A; Department of Biochemistry, Kawasaki Medical School, Okayama, Japan., Fujita S; Department of Oral Pathology, Institute of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
المصدر: Oral diseases [Oral Dis] 2023 Nov; Vol. 29 (8), pp. 3193-3204. Date of Electronic Publication: 2022 Jun 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Munksgaard Country of Publication: Denmark NLM ID: 9508565 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1601-0825 (Electronic) Linking ISSN: 1354523X NLM ISO Abbreviation: Oral Dis
أسماء مطبوعة: Publication: 2001- : Copenhagen, Denmark : Munksgaard
Original Publication: Houndmills, Basingstoke, Hampshire, UK : Stockton Press, c1995-
مواضيع طبية MeSH: Carcinoma, Squamous Cell*/pathology , Mouth Neoplasms* , Esophageal Squamous Cell Carcinoma* , Esophageal Neoplasms* , Head and Neck Neoplasms*, Humans ; Proto-Oncogene Proteins c-akt/metabolism ; Intercellular Signaling Peptides and Proteins/metabolism ; Squamous Cell Carcinoma of Head and Neck ; Prognosis ; Cell Proliferation ; Cell Line, Tumor ; Membrane Proteins/metabolism ; Adaptor Proteins, Signal Transducing
مستخلص: Objective: We previously reported that dickkopf WNT signaling inhibitor 3 (DKK3) would modulate malignant potential of oral squamous cell carcinoma (OSCC) via activating Akt. Recently, cytoskeleton associated protein 4 (CKAP4) functions as receptor of DKK3, which activates Akt in esophageal squamous cell carcinoma, but its expression and function in OSCC were unclear.
Methods: We studied DKK3 and CKAP4 protein expression in OSCC tissue and investigated the correlation between protein expression and clinical data. We also investigated whether antibodies (Ab) for DKK3 or CKAP4 could suppress malignant potential of the cancer cells.
Results: DKK3/CKAP4 protein expression was observed in majority of OSCC cases and was associated with significantly higher T-stage and TNM stage. Multivariate analysis revealed that DKK3 and CKAP4 were independent prognostic biomarkers for overall survival (OS) and disease-free survival (DFS), respectively. Survival analyses revealed that DKK3-positive cases and CKAP4-positive cases showed significantly shorter OS and DFS, respectively, and that DKK3/CKAP4 double-negative cases showed significantly favorable prognosis. Both anti-DKK3Ab and anti-CKAP4Ab could suppress cancer cell proliferation, migration, and invasion.
Conclusion: DKK3/CKAP4 axis is thought to be important in OSCC, and it would be a promising therapeutic target.
(© 2022 Wiley Periodicals LLC.)
References: Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 68(6), 394-424.
Bulsara, V. M., Worthington, H. V., Glenny, A.-M., Clarkson, J. E., Conway, D. I., & Macluskey, M. (2018). Interventions for the treatment of oral and oropharyngeal cancers: Surgical treatment. Cochrane Database of Systematic Reviews, 12(12), CD006205.
Conrads, T. P., Tocci, G. M., Hood, B. L., Zhang, C. O., Guo, L., Koch, K. R., Michejda, C. J., Veenstra, T. D., & Keay, S. K. (2006). CKAP4/p63 is a receptor for the frizzled-8 protein-related antiproliferative factor from interstitial cystitis patients. The Journal of Biological Chemistry, 281(49), 37836-37843.
El-Nagger, A. K., Chan, J. K. C., Grandis, J. R., Takata, T., & Slootweg, P. J. (Eds.). (2017). WHO classification of head and neck tumours (4th ed.). IARC.
Fujii, M., Katase, N., Lefeuvre, M., Gunduz, M., Buery, R. R., Tamamura, R., Tsujigiwa, H., & Nagatsuka, H. (2011). Dickkopf (Dkk)-3 and β-catenin expressions increased in the transition from normal oral mucosal to oral squamous cell carcinoma. Journal of Molecular Histology, 42(6), 499-504.
Gao, L., Wang, Q., Ren, W., Zheng, J., Li, S., Dou, Z., Kong, X., Liang, X., & Zhi, K. (2020). The RBP1-CKAP4 axis activates oncogenic autophagy and promotes cancer progression in oral squamous cell carcinoma. Cell Death & Disease, 11(6), 488.
Hamzehzadeh, L., Caraglia, M., Atkin, S. L., & Sahebkar, A. (2018). Dickkopf homolog 3 (DKK3): A candidate for detection and treatment of cancers? Journal of Cellular Physiology, 233(6), 4595-4605.
Kajiwara, C., Fumoto, K., Kimura, H., Nojima, S., Asano, K., Odagiri, K., Yamasaki, M., Hikita, H., Takehara, T., Doki, Y., Morii, E., & Kikuchi, A. (2018). p63-dependent Dickkopf3 expression promotes esophageal cancer cell proliferation via CKAP4. Cancer Research, 78(21), 6107-6120.
Karasawa, T., Wang, Q., David, L. L., & Steyger, P. S. (2010). CLIMP-63 is a gentamicin-binding protein that is involved in drug-induced cytotoxicity. Cell Death & Disease, 1(11), e102.
Katase, N., Lefeuvre, M., Gunduz, M., Gunduz, E., Beder, L. B., Grenman, R., Fujii, M., Tamamura, R., Tsujigiwa, H., & Nagatsuka, H. (2012). Absence of Dickkopf (Dkk)-3 protein expression is correlated with longer disease-free survival and lower incidence of metastasis in head and neck squamous cell carcinoma. Oncology Letters, 3(2), 273-280.
Katase, N., Lefeuvre, M., Tsujigiwa, H., Fujii, M., Ito, S., Tamamura, R., Buery, R. R., Gunduz, M., & Nagatsuka, H. (2013). Knockdown of Dkk-3 decreases cancer cell migration and invasion independently of the Wnt pathways in oral squamous cell carcinoma-derived cells. Oncology Reports, 29(4), 1349-1355.
Katase, N., Nagano, K., & Fujita, S. (2020). DKK3 expression and function in head and neck squamous cell carcinoma and other cancers. J Oral Biosci., 62(1), 9-15.
Katase, N., Nishimatsu, S. I., Yamauchi, A., Yamamura, M., & Fujita, S. (2019). DKK3 knockdown confers negative effects on the malignant potency of head and neck squamous cell carcinoma cells via the PI3K/Akt and MAPK signaling pathways. International Journal of Oncology, 54(3), 1021-1032.
Katase, N., Nishimatsu, S. I., Yamauchi, A., Yamamura, M., Terada, K., Itadani, M., Okada, N., Hassan, N. M. M., Nagatsuka, H., Ikeda, T., Nohno, T., & Fujita, S. (2018). DKK3 overexpression increases the malignant properties of head and neck squamous cell carcinoma cells. Oncology Research, 26(1), 45-58.
Kikuchi, A., Fumoto, K., & Kimura, H. (2017). The Dickkopf1-cytoskeleton-associated protein 4 axis creates a novel signalling pathway and may represent a molecular target for cancer therapy. British Journal of Pharmacology, 174(24), 4651-4665.
Kimura, H., Fumoto, K., Shojima, K., Nojima, S., Osugi, Y., Tomihara, H., Eguchi, H., Shintani, Y., Endo, H., Inoue, M., Doki, Y., Okumura, M., Morii, E., & Kikuchi, A. (2016). CKAP4 is a Dickkopf1 receptor and is involved in tumor progression. The Journal of Clinical Investigation, 126(7), 2689-2705.
Kimura, H., Yamamoto, H., Harada, T., Fumoto, K., Osugi, Y., Sada, R., Maehara, N., Hikita, H., Mori, S., Eguchi, H., Ikawa, M., Takehara, T., & Kikuchi, A. (2019). CKAP4, a DKK1 receptor, is a biomarker in exosomes derived from pancreatic cancer and a molecular target for therapy. Clinical Cancer Research, 25(6), 1936-1947.
Kumon, H., Ariyoshi, Y., Sasaki, K., Sadahira, T., Araki, M., Ebara, S., Yanai, H., Watanabe, M., & Nasu, Y. (2016). Adenovirus vector carrying REIC/DKK-3 gene: Neoadjuvant intraprostatic injection for high-risk localized prostate cancer undergoing radical prostatectomy. Cancer Gene Therapy, 23(11), 400-409.
Lee, E. J., Nguyen, Q. T. T., & Lee, M. (2020). Dickkopf-3 in human malignant tumours: A clinical viewpoint. Anticancer Research, 40(11), 5969-5979.
Leonard, J. L., Leonard, D. M., Wolfe, S. A., Liu, J., Rivera, J., Yang, M., Leonard, R. T., Johnson, J. P. S., Kumar, P., Liebmann, K. L., Tutto, A. A., Mou, Z., & Simin, K. J. (2017). The Dkk3 gene encodes a vital intracellular regulator of cell proliferation. PLoS One, 12(7), e0181724.
Li, M. H., Dong, L. W., Li, S. X., Tang, G. S., Pan, Y. F., Zhang, J., Wang, H., Zhou, H. B., Tan, Y. X., Hu, H. P., & Wang, H. Y. (2013). Expression of cytoskeleton-associated protein 4 is related to lymphatic metastasis and indicates prognosis of intrahepatic cholangiocarcinoma patients after surgery resection. Cancer Letters, 337(2), 248-253.
Li, S. X., Li, J., Dong, L. W., & Guo, Z. Y. (2021). Cytoskeleton-associated protein 4, a promising biomarker for tumor diagnosis and therapy. Frontiers in Molecular Biosciences, 7, 552056.
Li, S. X., Tang, G. S., Zhou, D. X., Pan, Y. F., Tan, Y. X., Zhang, J., Zhang, B., Ding, Z. W., Liu, L. J., Jiang, T. Y., Hu, H. P., Dong, L. W., & Wang, H. Y. (2014). Prognostic significance of cytoskeleton-associated membrane protein 4 and its palmitoyl acyltransferase DHHC2 in hepatocellular carcinoma. Cancer, 120(10), 1520-1531.
Madera, M., Tirado Amador, L., & Leal, A. C. (2021). Therapeutic options in unresectable Oral squamous cell carcinoma: A systematic review. Cancer Management and Research, 13, 6705-6719.
Muraro, E., Fanetti, G., Lupato, V., Giacomarra, V., Steffan, A., Gobitti, C., Vaccher, E., & Franchin, G. (2021). Cetuximab in locally advanced head and neck squamous cell carcinoma: Biological mechanisms involved in efficacy, toxicity and resistance. Critical Reviews in Oncology/Hematology, 164, 103424.
Oyama, A., Shiraha, H., Uchida, D., Iwamuro, M., Kato, H., Takaki, A., Ikeda, F., Onishi, H., Yasunaka, T., Takeuchi, Y., Wada, N., Iwasaki, Y., Sakata, M., Okada, H., & Kumon, H. (2019). A phase I/Ib trial of ad-REIC in liver cancer: Study protocol. Future Oncology, 31, 3547-3554.
Patel, B., & Saba, N. F. (2021). Current aspects and future considerations of EGFR inhibition in locally advanced and recurrent metastatic squamous cell carcinoma of the head and neck. Cancers (Basel), 13(14), 3545.
Shinno, N., Kimura, H., Sada, R., Takiguchi, S., Mori, M., Fumoto, K., Doki, Y., & Kikuchi, A. (2018). Activation of the Dickkopf1-CKAP4 pathway is associated with poor prognosis of esophageal cancer and anti-CKAP4 antibody may be a new therapeutic drug. Oncogene, 37(26), 3471-3484.
Siegel, R. L., Miller, K. D., & Jemal, A. (2017). Cancer statistics, 2017. CA: A Cancer Journal for Clinicians, 67(1), 7-30.
Tang, X., He, J., Li, B., Zheng, Y., Li, K., Zou, S., & Chen, L. (2019). Efficacy and safety of gefitinib in patients with advanced head and neck squamous cell carcinoma: A meta-analysis of randomized controlled trials. Journal of Oncology, 2019, 6273438.
The Cancer Genome Atlas Network. (2015). Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature, 517(7536), 576-582.
Tsuji, T., Miyazaki, M., Sakaguchi, M., Inoue, Y., & Namba, M. (2000). A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines. Biochemical and Biophysical Research Communications, 268(1), 20-24.
Wang, H., Zhao, Q., Zhang, Y., Wei, J., Wang, B., Zheng, Z., Liu, S., Liu, Z., Meng, L., Xin, Y., & Jiang, X. (2021). Efficacy and safety of systemic treatments for patients with recurrent/metastatic head and neck squamous cell carcinoma: A systematic review and network meta-analysis. Pharmacological Research, 173, 105866.
Wang, Z., Lin, L., Thomas, D. G., Nadal, E., Chang, A. C., Beer, D. G., & Lin, J. (2015). The role of Dickkopf-3 overexpression in esophageal adenocarcinoma. The Journal of Thoracic and Cardiovascular Surgery, 150(2), 377-385.e2.
Westin, S. N., Fellman, B., Sun, C. C., Broaddus, R. R., Woodall, M. L., Pal, N., Urbauer, D. L., Ramondetta, L. M., Schmeler, K. M., Soliman, P. T., Fleming, N. D., Burzawa, J. K., Nick, A. M., Milbourne, A. M., Yuan, Y., Lu, K. H., Bodurka, D. C., Coleman, R. L., & Yates, M. S. (2021). Prospective phase II trial of levonorgestrel intrauterine device: Nonsurgical approach for complex atypical hyperplasia and early-stage endometrial cancer. American Journal of Obstetrics and Gynecology, 224(2), 191.e1-191.e15.
Zenzmaier, C., Hermann, M., Hengster, P., & Berger, P. (2012). Dickkopf-3 maintains the PANC-1 human pancreatic tumor cells in a dedifferentiated state. International Journal of Oncology, 40(1), 40-46.
Zhou, L., Husted, H., Moore, T., Lu, M., Deng, D., Liu, Y., Ramachandran, V., Arumugam, T., Niehrs, C., Wang, H., Chiao, P., Ling, J., Curran, M. A., Maitra, A., Hung, M. C., Lee, J. E., Logsdon, C. D., & Hwang, R. F. (2018). Suppression of stromal-derived Dickkopf-3 (DKK3) inhibits tumor progression and prolongs survival in pancreatic ductal adenocarcinoma. Science Translational Medicine, 10(464), eaat3487.
معلومات مُعتمدة: Grant-in-Aid for Scientific Research (20K09908) Ministry of Education, Culture, Sports, Science and Technology
فهرسة مساهمة: Keywords: CKAP4; DKK3; head and neck cancer; oral squamous cell carcinoma
المشرفين على المادة: EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
0 (Intercellular Signaling Peptides and Proteins)
0 (CKAP4 protein, human)
0 (Membrane Proteins)
0 (DKK3 protein, human)
0 (Adaptor Proteins, Signal Transducing)
تواريخ الأحداث: Date Created: 20220616 Date Completed: 20231207 Latest Revision: 20231207
رمز التحديث: 20240628
DOI: 10.1111/odi.14277
PMID: 35708905
قاعدة البيانات: MEDLINE
الوصف
تدمد:1601-0825
DOI:10.1111/odi.14277