دورية أكاديمية
DKK3/CKAP4 axis is associated with advanced stage and poorer prognosis in oral cancer.
العنوان: | DKK3/CKAP4 axis is associated with advanced stage and poorer prognosis in oral cancer. |
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المؤلفون: | Katase N; Department of Oral Pathology, Institute of Biomedical Sciences, Nagasaki University, Nagasaki, Japan., Kudo K; Department of Oral Pathology, Institute of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.; Nagasaki University Dental School, Nagasaki, Japan., Ogawa K; Department of Oral Pathology, Institute of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.; Nagasaki University Dental School, Nagasaki, Japan., Sakamoto Y; Department of Oral Pathology, Institute of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.; Nagasaki University Dental School, Nagasaki, Japan., Nishimatsu SI; Department of Natural Sciences, Kawasaki Medical School, Okayama, Japan., Yamauchi A; Department of Biochemistry, Kawasaki Medical School, Okayama, Japan., Fujita S; Department of Oral Pathology, Institute of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. |
المصدر: | Oral diseases [Oral Dis] 2023 Nov; Vol. 29 (8), pp. 3193-3204. Date of Electronic Publication: 2022 Jun 29. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Munksgaard Country of Publication: Denmark NLM ID: 9508565 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1601-0825 (Electronic) Linking ISSN: 1354523X NLM ISO Abbreviation: Oral Dis |
أسماء مطبوعة: | Publication: 2001- : Copenhagen, Denmark : Munksgaard Original Publication: Houndmills, Basingstoke, Hampshire, UK : Stockton Press, c1995- |
مواضيع طبية MeSH: | Carcinoma, Squamous Cell*/pathology , Mouth Neoplasms* , Esophageal Squamous Cell Carcinoma* , Esophageal Neoplasms* , Head and Neck Neoplasms*, Humans ; Proto-Oncogene Proteins c-akt/metabolism ; Intercellular Signaling Peptides and Proteins/metabolism ; Squamous Cell Carcinoma of Head and Neck ; Prognosis ; Cell Proliferation ; Cell Line, Tumor ; Membrane Proteins/metabolism ; Adaptor Proteins, Signal Transducing |
مستخلص: | Objective: We previously reported that dickkopf WNT signaling inhibitor 3 (DKK3) would modulate malignant potential of oral squamous cell carcinoma (OSCC) via activating Akt. Recently, cytoskeleton associated protein 4 (CKAP4) functions as receptor of DKK3, which activates Akt in esophageal squamous cell carcinoma, but its expression and function in OSCC were unclear. Methods: We studied DKK3 and CKAP4 protein expression in OSCC tissue and investigated the correlation between protein expression and clinical data. We also investigated whether antibodies (Ab) for DKK3 or CKAP4 could suppress malignant potential of the cancer cells. Results: DKK3/CKAP4 protein expression was observed in majority of OSCC cases and was associated with significantly higher T-stage and TNM stage. Multivariate analysis revealed that DKK3 and CKAP4 were independent prognostic biomarkers for overall survival (OS) and disease-free survival (DFS), respectively. Survival analyses revealed that DKK3-positive cases and CKAP4-positive cases showed significantly shorter OS and DFS, respectively, and that DKK3/CKAP4 double-negative cases showed significantly favorable prognosis. Both anti-DKK3Ab and anti-CKAP4Ab could suppress cancer cell proliferation, migration, and invasion. Conclusion: DKK3/CKAP4 axis is thought to be important in OSCC, and it would be a promising therapeutic target. (© 2022 Wiley Periodicals LLC.) |
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معلومات مُعتمدة: | Grant-in-Aid for Scientific Research (20K09908) Ministry of Education, Culture, Sports, Science and Technology |
فهرسة مساهمة: | Keywords: CKAP4; DKK3; head and neck cancer; oral squamous cell carcinoma |
المشرفين على المادة: | EC 2.7.11.1 (Proto-Oncogene Proteins c-akt) 0 (Intercellular Signaling Peptides and Proteins) 0 (CKAP4 protein, human) 0 (Membrane Proteins) 0 (DKK3 protein, human) 0 (Adaptor Proteins, Signal Transducing) |
تواريخ الأحداث: | Date Created: 20220616 Date Completed: 20231207 Latest Revision: 20231207 |
رمز التحديث: | 20240628 |
DOI: | 10.1111/odi.14277 |
PMID: | 35708905 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1601-0825 |
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DOI: | 10.1111/odi.14277 |