دورية أكاديمية
أعرض في EDS

Temporal trends of aortic stenosis and comorbid chronic kidney disease in the province of Quebec, Canada.

التفاصيل البيبلوغرافية
العنوان: Temporal trends of aortic stenosis and comorbid chronic kidney disease in the province of Quebec, Canada.
المؤلفون: Khelifi N; Division of Nephrology, Endocrinology and Nephrology Axis, CHU de Quebec Research Center, Quebec, Quebec, Canada.; Faculty and Department of Medicine, Université Laval, Quebec, Quebec, Canada., Blais C; Institut National de Santé Publique du Québec, Quebec, Quebec, Canada.; Faculty of Pharmacy, Université Laval, Quebec, Quebec, Canada., Jean S; Faculty and Department of Medicine, Université Laval, Quebec, Quebec, Canada.; Institut National de Santé Publique du Québec, Quebec, Quebec, Canada., Hamel D; Institut National de Santé Publique du Québec, Quebec, Quebec, Canada., Clavel MA; Medicine, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec, Quebec, Canada., Pibarot P; Medicine, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec, Quebec, Canada., Mac-Way F; Division of Nephrology, Endocrinology and Nephrology Axis, CHU de Quebec Research Center, Quebec, Quebec, Canada fabrice.mac-way.med@ssss.gouv.qc.ca.; Faculty and Department of Medicine, Université Laval, Quebec, Quebec, Canada.
المصدر: Open heart [Open Heart] 2022 Jun; Vol. 9 (1).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BMJ Publishing Group Country of Publication: England NLM ID: 101631219 Publication Model: Print Cited Medium: Print ISSN: 2053-3624 (Print) Linking ISSN: 20533624 NLM ISO Abbreviation: Open Heart Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BMJ Publishing Group
مواضيع طبية MeSH: Aortic Valve Stenosis*/diagnostic imaging , Aortic Valve Stenosis*/epidemiology , Renal Insufficiency, Chronic*/diagnosis , Renal Insufficiency, Chronic*/epidemiology , Renal Insufficiency, Chronic*/therapy, Case-Control Studies ; Female ; Humans ; Male ; Quebec/epidemiology ; Renal Dialysis/adverse effects
مستخلص: Objective: To investigate temporal trends of chronic kidney disease (CKD) among patients with incident aortic stenosis (AS) and to compare these trends with that of a matched control population.
Methods: Using the Quebec Integrated Chronic Disease Surveillance System, we performed a population-based nested case-control study including 108 780 patients newly hospitalised with AS and 543 900 age-matched, sex-matched and fiscal year-matched patients without AS from 2000 to 2016 in Quebec (Canada). Three subgroups were considered. Dialysis subgroup had at least two outpatient billing codes of dialysis. The predialysis subgroup had at least one hospital or two billing diagnostic codes of CKD. The remaining individuals were included in the non-CKD subgroup. We estimated overall and sex-specific standardised annual proportions of CKD subgroups through direct standardisation using the 2016-2017 age structure of the incident AS cohort. The trends overtime were estimated through fitting robust Poisson regression models. Age-specific distribution of AS and control population were assessed for each subgroup.
Results: From 2000 to 2016, age-standardised proportions of patients with AS with dialysis and predialysis increased by 41% (99% CI 12.0% to 78.1%) and by 45% (99% CI 39.1% to 51.6%), respectively. Inversely, age-standardised proportions of dialysis and pre-dialysis among non-AS patients decreased by 63% (99% CI 55.8% to 68.7%) and by 32% (99% CI 29.9% to 34.6%), respectively, during the same study period. In patients with and without AS, age-standardised annual proportions of males in predialysis were significantly higher than females in most of the study period. Patients with AS on dialysis and predialysis were younger than their respective controls (dialysis: 29.6% vs 45.1% had ≥80 years, predialysis: 60.8% vs 72.7% had ≥80 years).
Conclusions: Over time, the proportion of patients with CKD increased significantly and remained consistently higher in incident AS individuals compared with controls. Our results highlight the need to investigate whether interventions targeting CKD risk factors may influence AS incidence in the future.
Competing Interests: Competing interests: Dr. Clavel has Core Laboratory contracts with Edwards Lifesciences, for which she receives no direct compensation, and research grant with Medtronic. Dr. Pibarot has Echocardiography Core Laboratory contracts with Edwards Lifesciences and Pi-Cardia, for which he receives no direct compensation. He is also the co-chair of a position statement of the American Heart association on Chronic Kidney Disease in Aortic Stenosis. The other authors report no conflicts.
(© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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فهرسة مساهمة: Keywords: Aortic Valve Stenosis; EPIDEMIOLOGY; Electronic Health Records; Global Burden of Disease
تواريخ الأحداث: Date Created: 20220616 Date Completed: 20220620 Latest Revision: 20220716
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9204438
DOI: 10.1136/openhrt-2021-001923
PMID: 35710290
قاعدة البيانات: MEDLINE
الوصف
تدمد:2053-3624
DOI:10.1136/openhrt-2021-001923