دورية أكاديمية

Glyphosate exposure modulates lipid composition, histo-architecture and oxidative stress status and induces neurotoxicity in the smooth scallop Flexopecten glaber.

التفاصيل البيبلوغرافية
العنوان: Glyphosate exposure modulates lipid composition, histo-architecture and oxidative stress status and induces neurotoxicity in the smooth scallop Flexopecten glaber.
المؤلفون: Telahigue K; Lab. of Ecology, Biology and Physiology of Aquatic Organisms (LR18ES41), Faculty of Sciences of Tunis, University Tunis El Manar, 2092 Tunis, Tunisia. Electronic address: ka.telahigue@gmail.com., Rabeh I; Lab. of Ecology, Biology and Physiology of Aquatic Organisms (LR18ES41), Faculty of Sciences of Tunis, University Tunis El Manar, 2092 Tunis, Tunisia., Mhadhbi L; Lab. of Ecology, Biology and Physiology of Aquatic Organisms (LR18ES41), Faculty of Sciences of Tunis, University Tunis El Manar, 2092 Tunis, Tunisia., Nechi S; Anatomy and Cytology Service, CHU Mohamed Taher Maamouri hospital, University Tunis El Manar, 2092 Tunis, Tunisia., Chelbi E; Anatomy and Cytology Service, CHU Mohamed Taher Maamouri hospital, University Tunis El Manar, 2092 Tunis, Tunisia., Ben Ali M; Department of Biology, College of Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia., Hedfi A; Department of Biology, College of Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia., Al-Harbi MS; Department of Biology, College of Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia., Hajji T; Lab. Of Biotechnology and Valorization fo Bio-GeResources (LR11ES31), Higher Institute of Biotechnology - Sidi Thabet, Biotechpole Sidi Thabet, University Manouba, 2020 Ariana, Tunisia.
المصدر: Pesticide biochemistry and physiology [Pestic Biochem Physiol] 2022 Jun; Vol. 184, pp. 105099. Date of Electronic Publication: 2022 Apr 16.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 1301573 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9939 (Electronic) Linking ISSN: 00483575 NLM ISO Abbreviation: Pestic Biochem Physiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York Ny : Academic Press
مواضيع طبية MeSH: Pectinidae*/metabolism , Water Pollutants, Chemical*/toxicity, Acetylcholinesterase/metabolism ; Animals ; Antioxidants/metabolism ; Glutathione/metabolism ; Glycine/analogs & derivatives ; Hydrogen Peroxide ; Lipids ; Oxidative Stress ; Superoxide Dismutase/metabolism ; Glyphosate
مستخلص: Glyphosate is the most sprayed pesticide across the globe. Its toxicity to non-target marine organisms has recently piqued the scientific community's interest. Therefore, the purpose of this study is to investigate the potentially toxic effects of glyphosate on scallops, an ecologically and economically important bivalve group. To do that, specimens of the smooth scallop Flexopecten glaber were exposed to different concentrations (10, 100, and 1000 μg L -1 ) of the technical-grade glyphosate acid (GLY) for 96 h. The detrimental effects of this pollutant were assayed at cellular and tissular levels. The obtained results showed that the GLY was able to induce oxidative stress in the gills and the digestive gland of F. glaber as revealed by the enhanced hydrogen peroxide (H 2 O 2 ), protein carbonyls (PCO), malondialdehyde (MDA), and lipid peroxides (LOOH) levels and the altered antioxidant defense system (the glutathione GSH content and the superoxide dismutase (SOD) activity). Additionally, GLY was found to alter the fatty acid profile, to exert a neurotoxic effect through the inhibition of the acetylcholinesterase (AChE) activity, and to provoke several histopathological damages in the two organs studied. The obtained results revealed that the pure form of GLY may exert toxic effects on F. glaber even at relatively low concentrations.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Fatty acids; Histopathology; Neurotoxicity; Organophosphorus herbicides; Oxidative stress; Pectinids
المشرفين على المادة: 0 (Antioxidants)
0 (Lipids)
0 (Water Pollutants, Chemical)
BBX060AN9V (Hydrogen Peroxide)
EC 1.15.1.1 (Superoxide Dismutase)
EC 3.1.1.7 (Acetylcholinesterase)
GAN16C9B8O (Glutathione)
TE7660XO1C (Glycine)
تواريخ الأحداث: Date Created: 20220617 Date Completed: 20220621 Latest Revision: 20231213
رمز التحديث: 20231215
DOI: 10.1016/j.pestbp.2022.105099
PMID: 35715038
قاعدة البيانات: MEDLINE
الوصف
تدمد:1095-9939
DOI:10.1016/j.pestbp.2022.105099