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Non-invasive vagus nerve stimulation in epilepsy patients enhances cooperative behavior in the prisoner's dilemma task.

التفاصيل البيبلوغرافية
العنوان: Non-invasive vagus nerve stimulation in epilepsy patients enhances cooperative behavior in the prisoner's dilemma task.
المؤلفون: Oehrn CR; Department of Neurology, Philipps-University Marburg, Marburg, Germany. carina.oehrn@staff.uni-marburg.de.; Center for Mind, Brain and Behavior (CMBB), Philipps-University Marburg, Marburg, Germany. carina.oehrn@staff.uni-marburg.de., Molitor L; Department of Neurology, Philipps-University Marburg, Marburg, Germany., Krause K; Department of Neurology, Philipps-University Marburg, Marburg, Germany.; Department of Neurology, Epilepsy Center Hessen, Philipps-University, Marburg, Germany., Niehaus H; Department of Psychology, Theoretical Neuroscience Section, Philipps-University Marburg, Marburg, Germany., Schmidt L; Department of Neurology, Philipps-University Marburg, Marburg, Germany., Hakel L; Department of Neurology, Philipps-University Marburg, Marburg, Germany., Timmermann L; Department of Neurology, Philipps-University Marburg, Marburg, Germany.; Center for Mind, Brain and Behavior (CMBB), Philipps-University Marburg, Marburg, Germany., Menzler K; Department of Neurology, Philipps-University Marburg, Marburg, Germany.; Department of Neurology, Epilepsy Center Hessen, Philipps-University, Marburg, Germany., Knake S; Department of Neurology, Philipps-University Marburg, Marburg, Germany.; Center for Mind, Brain and Behavior (CMBB), Philipps-University Marburg, Marburg, Germany.; Department of Neurology, Epilepsy Center Hessen, Philipps-University, Marburg, Germany., Weber I; Department of Neurology, Philipps-University Marburg, Marburg, Germany.
المصدر: Scientific reports [Sci Rep] 2022 Jun 17; Vol. 12 (1), pp. 10255. Date of Electronic Publication: 2022 Jun 17.
نوع المنشور: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Epilepsy*/therapy , Transcutaneous Electric Nerve Stimulation* , Vagus Nerve Stimulation*, Cooperative Behavior ; Humans ; Prisoner Dilemma ; Vagus Nerve/physiology
مستخلص: The vagus nerve constitutes a key link between the autonomic and the central nervous system. Previous studies provide evidence for the impact of vagal activity on distinct cognitive processes including functions related to social cognition. Recent studies in animals and humans show that vagus nerve stimulation is associated with enhanced reward-seeking and dopamine-release in the brain. Social interaction recruits similar brain circuits to reward processing. We hypothesize that vagus nerve stimulation (VNS) boosts rewarding aspects of social behavior and compare the impact of transcutaneous VNS (tVNS) and sham stimulation on social interaction in 19 epilepsy patients in a double-blind pseudo-randomized study with cross-over design. Using a well-established paradigm, i.e., the prisoner's dilemma, we investigate effects of stimulation on cooperative behavior, as well as interactions of stimulation effects with patient characteristics. A repeated-measures ANOVA and a linear mixed-effects model provide converging evidence that tVNS boosts cooperation. Post-hoc correlations reveal that this effect varies as a function of neuroticism, a personality trait linked to the dopaminergic system. Behavioral modeling indicates that tVNS induces a behavioral starting bias towards cooperation, which is independent of the decision process. This study provides evidence for the causal influence of vagus nerve activity on social interaction.
(© 2022. The Author(s).)
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تواريخ الأحداث: Date Created: 20220617 Date Completed: 20220621 Latest Revision: 20221113
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9205877
DOI: 10.1038/s41598-022-14237-3
PMID: 35715460
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-022-14237-3