دورية أكاديمية
Uncertain in the face of change: Lack of contingency shift awareness during extinction is associated with higher fear-potentiated startle and PTSD symptoms in children.
| العنوان: | Uncertain in the face of change: Lack of contingency shift awareness during extinction is associated with higher fear-potentiated startle and PTSD symptoms in children. |
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| المؤلفون: | Jovanovic T; Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, United States. Electronic address: tjovanovic@med.wayne.edu., Wiltshire CN; Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, United States., Reda MH; Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, United States., France J; Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, United States., Wanna CP; Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, United States., Minton ST; Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, United States., Davie W; Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, United States., Grasser LR; Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, United States., Winters S; Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, United States., Schacter H; Department of Psychology, Wayne State University, Detroit, MI, United States., Marusak HA; Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, United States., Stenson AF; Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, United States. |
| المصدر: | International journal of psychophysiology : official journal of the International Organization of Psychophysiology [Int J Psychophysiol] 2022 Aug; Vol. 178, pp. 90-98. Date of Electronic Publication: 2022 Jun 16. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8406214 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7697 (Electronic) Linking ISSN: 01678760 NLM ISO Abbreviation: Int J Psychophysiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier, [c1983- |
| مواضيع طبية MeSH: | Stress Disorders, Post-Traumatic*, Adolescent ; Child ; Extinction, Psychological/physiology ; Fear/physiology ; Humans ; Phobic Disorders ; Reflex, Startle/physiology ; Uncertainty |
| مستخلص: | Intolerance of uncertainty is a transdiagnostic risk factor for fear-related disorders and is associated with higher levels of anxiety in children and adolescents. It is unclear how uncertainty relates to development of psychopathology in children who have experienced trauma in early life. The present study used a fear-potentiated startle paradigm in children to examine associations between uncertainty (assessed as unawareness of a change in reinforcement during fear extinction) and symptoms of anxiety and posttraumatic stress disorder (PTSD), as well as startle potentiation to threat and safety cues. Results showed that unaware children had strong positive associations between trauma exposure and PTSD symptoms, whereas aware children did not. Uncertainty interacted with anxiety in that children who were both unaware and had higher anxiety displayed higher fear-potentiated startle to safety cues and did not show discrimination between threat and safety during fear conditioning. These results suggest that anxious children who persist in associating a threat cue with an aversive event during extinction, after repeated presentations of the no longer reinforced conditioned stimulus, may express psychophysiological phenotypes related to PTSD. (Copyright © 2022 Elsevier B.V. All rights reserved.) |
| معلومات مُعتمدة: | R01 GM111682 United States GM NIGMS NIH HHS |
| فهرسة مساهمة: | Keywords: Anxiety; Children; Fear conditioning; Fear extinction; PTSD; Uncertainty |
| SCR Disease Name: | Phobia, Specific |
| تواريخ الأحداث: | Date Created: 20220619 Date Completed: 20220712 Latest Revision: 20230610 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.ijpsycho.2022.06.008 |
| PMID: | 35718286 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7697 |
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| DOI: | 10.1016/j.ijpsycho.2022.06.008 |