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Novel Association between Opioid Use and Increased Risk of Retinal Vein Occlusion Using the National Institutes of Health All of Us Research Program.

التفاصيل البيبلوغرافية
العنوان: Novel Association between Opioid Use and Increased Risk of Retinal Vein Occlusion Using the National Institutes of Health All of Us Research Program.
المؤلفون: McDermott JJ 4th; Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, La Jolla, California.; Health Department of Biomedical Informatics, University of California San Diego, La Jolla, California., Lee TC; Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, La Jolla, California.; Health Department of Biomedical Informatics, University of California San Diego, La Jolla, California., Chan AX; Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, La Jolla, California.; Health Department of Biomedical Informatics, University of California San Diego, La Jolla, California., Ye GY; Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, La Jolla, California.; Health Department of Biomedical Informatics, University of California San Diego, La Jolla, California., Shahrvini B; Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, La Jolla, California.; Health Department of Biomedical Informatics, University of California San Diego, La Jolla, California., Saseendrakumar BR; Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, La Jolla, California.; Health Department of Biomedical Informatics, University of California San Diego, La Jolla, California., Ferreyra H; Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, La Jolla, California., Nudleman E; Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, La Jolla, California., Baxter SL; Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, La Jolla, California.; Health Department of Biomedical Informatics, University of California San Diego, La Jolla, California.
المصدر: Ophthalmology science [Ophthalmol Sci] 2022 Mar; Vol. 2 (1). Date of Electronic Publication: 2021 Dec 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 9918230896206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-9145 (Electronic) Linking ISSN: 26669145 NLM ISO Abbreviation: Ophthalmol Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam] : Elsevier, B.V., [2021]-
مستخلص: Purpose: To assess for risk factors for retinal vein occlusion (RVO) among participants in the National Institutes of Health All of Us database, particularly social risk factors that have not been well studied, including substance use.
Design: Retrospective, case-control study.
Participants: Data were extracted for 380 adult participants with branch retinal vein occlusion (BRVO), 311 adult participants with central retinal vein occlusion (CRVO), and 1520 controls sampled among 311 640 adult participants in the All of Us database.
Methods: Data were extracted regarding demographics, comorbidities, income, housing, insurance, and substance use. Opioid use was defined by relevant diagnosis and prescription codes, with prescription use > 30 days. Controls were sampled at a 4:1 control to case ratio from a pool of individuals aged > 18 years without a diagnosis of RVO and proportionally matched to the demographic distribution of the 2019 U.S. census. Multivariable logistic regression identified medical and social determinants significantly associated with BRVO or CRVO. Statistical significance was defined as P < 0.05.
Main Outcome Measure: Development of BRVO or CRVO based on diagnosis codes.
Results: Among patients with BRVO, the mean (standard deviation) age was 70.1 (10.5) years. The majority (53.7%) were female. Cases were diverse; 23.7% identified as Black, and 18.4% identified as Hispanic or Latino. Medical risk factors including glaucoma (odds ratio [OR], 3.29; 95% confidence interval [CI], 2.22-4.90; P < 0.001), hypertension (OR, 2.15; 95% CI, 1.49-3.11; P < 0.001), and diabetes mellitus (OR, 1.68; 95% CI, 1.18-2.38; P = 0.004) were re-demonstrated to be associated with BRVO. Black race (OR, 2.64; 95% CI, 1.22-6.05; P = 0.017) was found to be associated with increased risk of BRVO. Past marijuana use (OR, 0.68; 95% CI, 0.50-0.92; P = 0.013) was associated with decreased risk of BRVO; however, opioid use (OR, 1.98; 95% CI, 1.41-2.78; P < 0.001) was associated with a significantly increased risk of BRVO. Similar associations were found for CRVO.
Conclusions: Understanding RVO risk factors is important for primary prevention and improvement in visual outcomes. This study capitalizes on the diversity and scale of a novel nationwide database to elucidate a previously uncharacterized association between RVO and opioid use.
التعليقات: Erratum in: Ophthalmol Sci. 2023 Sep 27;3(3):100317. (PMID: 37810587)
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معلومات مُعتمدة: OT2 OD026556 United States OD NIH HHS; DP5 OD029610 United States OD NIH HHS; U2C OD023196 United States OD NIH HHS; OT2 OD025315 United States OD NIH HHS; OT2 OD026551 United States OD NIH HHS; U24 OD023121 United States OD NIH HHS; OT2 OD026552 United States OD NIH HHS; OT2 OD026549 United States OD NIH HHS; OT2 OD025337 United States OD NIH HHS; OT2 OD025277 United States OD NIH HHS; OT2 OD026555 United States OD NIH HHS; OT2 OD026550 United States OD NIH HHS; OT2 OD026553 United States OD NIH HHS; OT2 OD023205 United States OD NIH HHS; OT2 OD025276 United States OD NIH HHS; OT2 OD026557 United States OD NIH HHS; OT2 OD026554 United States OD NIH HHS; U24 OD023163 United States OD NIH HHS; OT2 OD023206 United States OD NIH HHS; U24 OD023176 United States OD NIH HHS; OT2 OD026548 United States OD NIH HHS
فهرسة مساهمة: Keywords: All of Us; Big data; Diversity; Electronic health records; Opioid-related disorders; Retinal vascular disease; Retinal vein occlusions; Social determinants of health; Substance use; Surveys
تواريخ الأحداث: Date Created: 20220620 Latest Revision: 20240211
رمز التحديث: 20240211
مُعرف محوري في PubMed: PMC9205363
DOI: 10.1016/j.xops.2021.100099
PMID: 35721456
قاعدة البيانات: MEDLINE
الوصف
تدمد:2666-9145
DOI:10.1016/j.xops.2021.100099