دورية أكاديمية
Assessment of serum androgen levels in women with acne vulgaris in Southeastern Nigeria: a cross-sectional study.
| العنوان: | Assessment of serum androgen levels in women with acne vulgaris in Southeastern Nigeria: a cross-sectional study. |
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| المؤلفون: | Anaje CC; Department of Internal Medicine, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria., Onyekonwu CL; University of Nigeria Teaching Hospital, Ituku Ozalla, Enugu State, Nigeria., Ozoh GA; University of Nigeria Teaching Hospital, Ituku Ozalla, Enugu State, Nigeria., Ezejiofor OI; Department of Internal Medicine, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria. |
| المصدر: | The Pan African medical journal [Pan Afr Med J] 2022 Mar 18; Vol. 41, pp. 227. Date of Electronic Publication: 2022 Mar 18 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: African Field Epidemiology Network Country of Publication: Uganda NLM ID: 101517926 Publication Model: eCollection Cited Medium: Internet ISSN: 1937-8688 (Electronic) NLM ISO Abbreviation: Pan Afr Med J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Kampala, Uganda : African Field Epidemiology Network |
| مواضيع طبية MeSH: | Acne Vulgaris*/etiology , Androgens*, Androstenedione ; Cross-Sectional Studies ; Female ; Humans ; Nigeria ; Testosterone |
| مستخلص: | Introduction: androgens play an important role in the pathogenesis of acne vulgaris. They cause hyperkeratinization of the pilosebaceous follicles and seborrhea. Endocrine diseases characterized by increased levels of androgens often present with acne vulgaris. A correlation between serum androgen levels and acne severity exists, and the assessment of serum androgen levels is therefore essential in women with severe acne vulgaris and treatment resistant acne. Methods: the study was conducted in the Dermatology Clinic of the University of Nigeria Teaching Hospital, Ituku Ozalla. Seventy females with acne vulgaris and seventy females without acne vulgaris were recruited as subjects and controls respectively. Blood samples were taken from subjects and controls to measure levels of serum testosterone, dehydroepiandrosterone sulfate (DHEAS) and androstenedione. Acne severity was measured using global acne grading system (GAGS). Results: the median levels of DHEAS and androstenedione (1.20µg/ml and 1.80ng/ml respectively) were higher in subjects than 1.00µg/ml and 1.70ng/ml in controls respectively, although these findings were not statistically significant. There was also no significant difference between the levels of serum testosterone in both the subjects and the controls. No correlation existed between levels of serum androgens and acne severity. Conclusion: there was no statistically significant difference in the serum androgen levels between the subjects and the control population, and no relationship between androgen levels and severity of acne vulgaris was demonstrated. Competing Interests: The authors declare no competing interest. (Copyright: Chetanna Chioma Anaje et al.) |
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| فهرسة مساهمة: | Keywords: Females; acne vulgaris; androgen levels; androstenedione; testosterone |
| المشرفين على المادة: | 0 (Androgens) 3XMK78S47O (Testosterone) 409J2J96VR (Androstenedione) |
| تواريخ الأحداث: | Date Created: 20220620 Date Completed: 20220621 Latest Revision: 20220716 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9167485 |
| DOI: | 10.11604/pamj.2022.41.227.32892 |
| PMID: | 35721630 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1937-8688 |
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| DOI: | 10.11604/pamj.2022.41.227.32892 |