دورية أكاديمية
Photodynamic potential of hexadecafluoro zinc phthalocyanine in nanostructured lipid carriers: physicochemical characterization, drug delivery and antimicrobial effect against Candida albicans.
| العنوان: | Photodynamic potential of hexadecafluoro zinc phthalocyanine in nanostructured lipid carriers: physicochemical characterization, drug delivery and antimicrobial effect against Candida albicans. |
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| المؤلفون: | Santos KLM; Graduate Program in Pharmaceutical Sciences, Biological and Health Sciences Center, State University of Paraíba (UEPB), Av. Juvêncio Arruda, s/n, Bairro Universitário, Campina Grande, Paraíba, 58429-600, Brazil., Nunes AMA; Graduate Program in Pharmaceutical Sciences, Biological and Health Sciences Center, State University of Paraíba (UEPB), Av. Juvêncio Arruda, s/n, Bairro Universitário, Campina Grande, Paraíba, 58429-600, Brazil., de Mendonça Y Araujo SED; Graduate Program in Pharmaceutical Sciences, Biological and Health Sciences Center, State University of Paraíba (UEPB), Av. Juvêncio Arruda, s/n, Bairro Universitário, Campina Grande, Paraíba, 58429-600, Brazil., de Melo DF; Graduate Program in Pharmaceutical Sciences, Biological and Health Sciences Center, State University of Paraíba (UEPB), Av. Juvêncio Arruda, s/n, Bairro Universitário, Campina Grande, Paraíba, 58429-600, Brazil., de Lima Damasceno BPG; Graduate Program in Pharmaceutical Sciences, Biological and Health Sciences Center, State University of Paraíba (UEPB), Av. Juvêncio Arruda, s/n, Bairro Universitário, Campina Grande, Paraíba, 58429-600, Brazil., Sato MR; Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil., Oshiro-Junior JA; Graduate Program in Pharmaceutical Sciences, Biological and Health Sciences Center, State University of Paraíba (UEPB), Av. Juvêncio Arruda, s/n, Bairro Universitário, Campina Grande, Paraíba, 58429-600, Brazil. joaooshiro@yahoo.com.br. |
| المصدر: | Lasers in medical science [Lasers Med Sci] 2022 Oct; Vol. 37 (8), pp. 3183-3191. Date of Electronic Publication: 2022 Jun 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: England NLM ID: 8611515 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-604X (Electronic) Linking ISSN: 02688921 NLM ISO Abbreviation: Lasers Med Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Springer Original Publication: London : Baillière Tindall, c1986- |
| مواضيع طبية MeSH: | Candida albicans* , Nanostructures*/chemistry, Antifungal Agents/pharmacology ; Drug Carriers/chemistry ; Drug Carriers/pharmacology ; Indoles ; Lipids/chemistry ; Organometallic Compounds ; Particle Size ; Singlet Oxygen |
| مستخلص: | This study aims to develop and characterize NCL loaded with ZnF16Pc (Pc) for application in antimicrobial photodynamic therapy. For the development of the NLC, the fusion-emulsification technique followed by sonication was applied. NLC and Pc-NLC were characterized in terms of mean diameter (Dm.n), polydispersity index (PdI), zeta potential (ZP), encapsulation efficiency (%EE), transmission electron microscopy (TEM), differential scanning (DSC), photobleaching and singlet oxygen generation in cellular systems (SOSG), and in vitro release assays performed by the beaker method, using dialysis membranes. Cell viability was performed by colony forming units (CFU/mL). The mean size of NLC and Pc-NLC was 158 nm ± 1.49 to 161.80 nm and showed PdI < 0.3 and ZP between -17.8 and -19.9, and stable during storage time (90 days). The TEM presented spherical particles, the Pc-NLC promoted the encapsulation of 75.57% ± 0.58. DSC analysis confirmed that there was no incompatibility between Pc and NLC. The analysis of the photodegradation profile proved to be photostable after encapsulation and this corroborates the data obtained by SOSG. In vitro release showed controlled and prolonged release. PDT Pc-NLC exhibited greater antifungal effect against C. albicans (3 log10 reduction) than Pc-NLC without light (1 log10 reduction). NLC can be an alternative to the application of Pc and improve the effect during PDT treatment. (© 2022. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Nanostructured delivery systems; Pharmaceutical nanotechnology; Photochemotherapy; Photosensitizers |
| المشرفين على المادة: | 0 (Antifungal Agents) 0 (Drug Carriers) 0 (Indoles) 0 (Lipids) 0 (Organometallic Compounds) 0 (hexadecafluoro zinc phthalocyanine) 17778-80-2 (Singlet Oxygen) |
| تواريخ الأحداث: | Date Created: 20220620 Date Completed: 20221004 Latest Revision: 20230320 |
| رمز التحديث: | 20230320 |
| DOI: | 10.1007/s10103-022-03594-0 |
| PMID: | 35723829 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1435-604X |
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| DOI: | 10.1007/s10103-022-03594-0 |