دورية أكاديمية
أعرض في EDS

Hilab system, a new point-of-care hematology analyzer supported by the Internet of Things and Artificial Intelligence.

التفاصيل البيبلوغرافية
العنوان: Hilab system, a new point-of-care hematology analyzer supported by the Internet of Things and Artificial Intelligence.
المؤلفون: Gasparin AT; Research and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil. alexia.gasparin@hilab.com.br., Araujo CIF; Research and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil., Schmitt P; Research and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil., Cardoso MR; Research and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil., Perussolo MC; Research and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil., de Jesus TCS; Research and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil., Santiago EB; Research and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil., Silva ILR; Research and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil., de Sousa RG; Research and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil., Teng FZ; Research and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil., Severo EB; Research and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil., Ribeiro VHA; Research and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil., Cardoso MA; Research and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil., Silva FD; Research and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil., de Araujo Perazzoli CR; Research and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil., de Holanda Farias JS; Erasto Gaertner Hospital, Ovande do Amaral, 201, Parana, Brazil., de Almeida BMM; Research and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil., Rogal Júnior SR; Research and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil., Figueredo MVM; Research and Development Department, Hilab, Hilab Campus, José A. Possebom, 800, Curitiba, Parana, 81270-185, Brazil.
المصدر: Scientific reports [Sci Rep] 2022 Jun 21; Vol. 12 (1), pp. 10409. Date of Electronic Publication: 2022 Jun 21.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Hematology* , Internet of Things*, Artificial Intelligence ; Blood Cell Count/methods ; Humans ; Point-of-Care Systems ; Reproducibility of Results
مستخلص: The complete blood count (CBC) is one of the most requested tests by physicians. CBC tests, most realized in conventional hematological analyzers, are restricted to centralized laboratories due to frequent maintenance, large devices, and expensive costs required. On the other hand, most handheld CBC devices commercially available show high prices and are not liable to calibration or control procedures, which results in poor quality compared to standard hematology instruments. The Hilab system is a small-handed hematological platform that uses microscopy and chromatography techniques for blood cells and hematimetric parameters analysis through artificial intelligence, machine learning, and deep learning techniques. For clinical evaluation of the handheld CBC device, 450 blood samples were analyzed. The samples encompassed normal (82%) and pathological conditions (18%), such as thalassemias (2.2%), anemias (6.6%), and infections (9.2%). For all analytes, accuracy, precision, method comparison, and flagging capabilities of the Hilab System, were compared with the Sysmex XE-2100 (Sysmex, Japan) results. The sample source (venous and capillary) influences were also evaluated. Pearson correlation, Student t test, bias, and the Bland-Altman plot of each blood count analyte were calculated and shown. The significance level was set at p ≤ 0.05. For clinical evaluation, Hilab System and the Sysmex XE-2100 showed a strong correlation (r ≥ 0.9) for most evaluated parameters. In the precision study, analytes showed CV inside the limits established according to European Federation of Clinical Chemistry and Laboratory Medicine guidelines. The flagging capabilities of the Hilab system, compared to the manual microscopy technique, presented high sensibility, specificity, and accuracy. Venous and capillary samples (p > 0.05) do not differ statistically. Considering the need for point-of-care CBCs, the study indicated that the Hilab system provides fast, accurate, low cost, and robust analysis for reliable clinical use.
(© 2022. The Author(s).)
References: J Appl Lab Med. 2019 Mar;3(5):839-846. (PMID: 31639758)
Lancet Glob Health. 2021 Nov;9(11):e1553-e1560. (PMID: 34626546)
Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24593-24599. (PMID: 31754026)
J Clin Pathol. 2016 Aug;69(8):720-5. (PMID: 26786235)
Am J Hematol. 2021 Oct 1;96(10):1264-1274. (PMID: 34264525)
Turk Pediatri Ars. 2020 Jun 19;55(2):103-116. (PMID: 32684755)
Rev Bras Epidemiol. 2019 Oct 07;22Suppl 02(Suppl 02):E190003.SUPL.2. (PMID: 31596374)
Sci Rep. 2019 Dec 9;9(1):18583. (PMID: 31819075)
Clin Chim Acta. 2008 Mar;389(1-2):120-5. (PMID: 18187044)
Int J Lab Hematol. 2009 Dec;31(6):657-64. (PMID: 18759736)
Lancet Infect Dis. 2018 Oct;18(10):1064-1065. (PMID: 30303097)
Transfusion. 2012 May;52(5):1031-40. (PMID: 22014071)
تواريخ الأحداث: Date Created: 20220621 Date Completed: 20220623 Latest Revision: 20220824
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9213419
DOI: 10.1038/s41598-022-13913-8
PMID: 35729182
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-022-13913-8