دورية أكاديمية
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Echis ocellatus Venom-Induced Reproductive Pathologies in Rat Model; Roles of Oxidative Stress and Pro-Inflammatory Cytokines.

التفاصيل البيبلوغرافية
العنوان: Echis ocellatus Venom-Induced Reproductive Pathologies in Rat Model; Roles of Oxidative Stress and Pro-Inflammatory Cytokines.
المؤلفون: Ajisebiola BS; Department of Zoology, Osun State University, Osogbo 230232, Nigeria., Alamu PI; Department of Zoology, Osun State University, Osogbo 230232, Nigeria., James AS; Biochemistry Program, Department of Chemical Science, Augustine University, Lagos 1010, Nigeria., Adeyi AO; Animal Physiology Unit, Department of Zoology, University of Ibadan, Ibadan 200005, Nigeria.
المصدر: Toxins [Toxins (Basel)] 2022 May 29; Vol. 14 (6). Date of Electronic Publication: 2022 May 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101530765 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6651 (Electronic) Linking ISSN: 20726651 NLM ISO Abbreviation: Toxins (Basel) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مواضيع طبية MeSH: Snake Bites*/pathology , Viperidae*, Animals ; Antivenins ; Cytokines ; Male ; Oxidative Stress ; Rats ; Rats, Wistar ; Semen ; Snake Venoms ; Sperm Motility ; Spermatozoa/pathology ; Testis/pathology
مستخلص: This study reported reproductive pathologies associated with Echis ocellatus venom in animal model. Twenty male Wistar rats with body weight between 180 and 220 g were selected randomly into two groups (n = 10). Rats in group 1 served as the control while rats in group 2 were envenomed with a single intraperitoneal injection of 0.055 mg/kg−1 (LD6.25) of E. ocellatus venom on the first day and a repeated dose on the twenty fifth day. Both control and envenomed rats were monitored for fifty consecutive days. The venom caused a significant (p < 0.05) reduction in sperm motility, count, and volume, with increased sperm anomalies in envenomed rats compared to the control. Likewise, serum concentrations of male reproductive hormones were significantly (p < 0.05) higher in envenomed rats. Increased levels of malondialdehyde were accompanied by a significant (p < 0.05) decrease in reduced glutathione and catalase activity in the epididymis and testis tissues of envenomed rats. The venom enhanced the release of epididymal and testicular tumor necrosis factor-alpha and interleukin1-beta compared to the control. Furthermore, severe pathological defects were noticed in tissues of the testis and epididymis of envenomed rats. This study demonstrated that E. ocellatus venom toxins can induce reproductive dysfunction in male victims of snake envenoming.
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فهرسة مساهمة: Keywords: Echis ocellatus; cytokines; envenoming; oxidant damage; reproduction; sex hormones
المشرفين على المادة: 0 (Antivenins)
0 (Cytokines)
0 (Snake Venoms)
تواريخ الأحداث: Date Created: 20220623 Date Completed: 20220627 Latest Revision: 20230308
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9227802
DOI: 10.3390/toxins14060378
PMID: 35737039
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6651
DOI:10.3390/toxins14060378