دورية أكاديمية
Spatial dynamics of inflammation-causing and commensal bacteria in the gastrointestinal tract.
| العنوان: | Spatial dynamics of inflammation-causing and commensal bacteria in the gastrointestinal tract. |
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| المؤلفون: | Aogo RA; Department of Mathematics and Statistics, Macquarie University, Sydney, NSW, Australia., Tanaka MM; School of Biotechnology and Biomolecular Sciences, UNSW Sydney, Australia; Evolution & Ecology Research Centre, UNSW Sydney, Australia., Penington CJ; Department of Mathematics and Statistics, Macquarie University, Sydney, NSW, Australia. |
| المصدر: | Journal of theoretical biology [J Theor Biol] 2022 Sep 07; Vol. 548, pp. 111194. Date of Electronic Publication: 2022 Jun 20. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 0376342 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8541 (Electronic) Linking ISSN: 00225193 NLM ISO Abbreviation: J Theor Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: London. |
| مواضيع طبية MeSH: | Bacteria* , Gastrointestinal Tract*, Humans ; Immunity ; Inflammation ; Symbiosis |
| مستخلص: | In recent years, new research programmes have been initiated to understand the role of gut bacteria in health and disease, enabled in large part by the emergence of high-throughput sequencing. As new genomic and other data emerge it will become important to explain observations in terms of underlying population mechanisms; for instance, it is of interest to understand how resident bacteria interact with their hosts and pathogens, and how they play a protective role. Connecting underlying processes with observed patterns is aided by the development of mathematical models. Here, we develop a spatial model of microbial populations in the gastrointestinal tract to explore conditions under which inflammation-causing bacteria can invade the gut and under which such pathogens become persistent. We find that pathogens invade both small and large intestine from even a relatively small inoculum size but are usually eliminated by the host response. When the immune response is weak, the pathogen is able to persist for a long period. Spatial structure affects these dynamics by creating moving refugia which facilitate bouts of pathogen resurgence and inflammation in persistent infections. Space also plays a role in repopulation by commensals after infection. We further find that the rate of decay of inflammation has a stronger effect on outcomes than the initiation of inflammation or other parameters. Finally, we explore the impact of partially inflammation-resistant commensals on these dynamics. Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: CJP and RAA were supported by Macquarie University’s Parental Leave Research Fellowship (awarded to CJP, which paid for the employment of RAA). MMT was supported by Australian Research Council grant DP170101917. (Copyright © 2022 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Gut bacteria; Inflammation; Mathematical model; Microbiota; Pathogen; Recolonisation; Spatial structure |
| تواريخ الأحداث: | Date Created: 20220623 Date Completed: 20220712 Latest Revision: 20221009 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.jtbi.2022.111194 |
| PMID: | 35738328 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1095-8541 |
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| DOI: | 10.1016/j.jtbi.2022.111194 |