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Gut virome profiling identifies a widespread bacteriophage family associated with metabolic syndrome.

التفاصيل البيبلوغرافية
العنوان: Gut virome profiling identifies a widespread bacteriophage family associated with metabolic syndrome.
المؤلفون: de Jonge PA; Departments of Internal and Experimental Vascular Medicine, Amsterdam University Medical Centers, Location AMC, Amsterdam, the Netherlands.; Amsterdam Gastroenterology Endocrinology Metabolism, Endocrinology, metabolism and nutrition, Amsterdam, the Netherlands.; Amsterdam Cardiovascular Sciences, Diabetes & Metabolism, Amsterdam, the Netherlands., Wortelboer K; Departments of Internal and Experimental Vascular Medicine, Amsterdam University Medical Centers, Location AMC, Amsterdam, the Netherlands.; Amsterdam Gastroenterology Endocrinology Metabolism, Endocrinology, metabolism and nutrition, Amsterdam, the Netherlands.; Amsterdam Cardiovascular Sciences, Diabetes & Metabolism, Amsterdam, the Netherlands., Scheithauer TPM; Departments of Internal and Experimental Vascular Medicine, Amsterdam University Medical Centers, Location AMC, Amsterdam, the Netherlands.; Amsterdam Gastroenterology Endocrinology Metabolism, Endocrinology, metabolism and nutrition, Amsterdam, the Netherlands.; Amsterdam Cardiovascular Sciences, Diabetes & Metabolism, Amsterdam, the Netherlands., van den Born BH; Departments of Internal and Experimental Vascular Medicine, Amsterdam University Medical Centers, Location AMC, Amsterdam, the Netherlands.; Amsterdam Gastroenterology Endocrinology Metabolism, Endocrinology, metabolism and nutrition, Amsterdam, the Netherlands.; Amsterdam Cardiovascular Sciences, Diabetes & Metabolism, Amsterdam, the Netherlands., Zwinderman AH; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam, the Netherlands., Nobrega FL; School of Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK., Dutilh BE; Theoretical Biology and Bioinformatics, Science for Life, Utrecht University, Utrecht, the Netherlands.; Institute of Biodiversity, Faculty of Biological Sciences, Cluster of Excellence Balance of the Microverse, Friedrich-Schiller-University Jena, Jena, Germany., Nieuwdorp M; Departments of Internal and Experimental Vascular Medicine, Amsterdam University Medical Centers, Location AMC, Amsterdam, the Netherlands.; Amsterdam Gastroenterology Endocrinology Metabolism, Endocrinology, metabolism and nutrition, Amsterdam, the Netherlands.; Amsterdam Cardiovascular Sciences, Diabetes & Metabolism, Amsterdam, the Netherlands., Herrema H; Departments of Internal and Experimental Vascular Medicine, Amsterdam University Medical Centers, Location AMC, Amsterdam, the Netherlands. h.j.herrema@amsterdamumc.nl.; Amsterdam Gastroenterology Endocrinology Metabolism, Endocrinology, metabolism and nutrition, Amsterdam, the Netherlands. h.j.herrema@amsterdamumc.nl.; Amsterdam Cardiovascular Sciences, Diabetes & Metabolism, Amsterdam, the Netherlands. h.j.herrema@amsterdamumc.nl.
المصدر: Nature communications [Nat Commun] 2022 Jun 23; Vol. 13 (1), pp. 3594. Date of Electronic Publication: 2022 Jun 23.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Bacteriophages*/genetics , Cardiovascular Diseases* , Metabolic Syndrome*, Bacteria/genetics ; Ecosystem ; Humans ; Virome/genetics
مستخلص: There is significant interest in altering the course of cardiometabolic disease development via gut microbiomes. Nevertheless, the highly abundant phage members of the complex gut ecosystem -which impact gut bacteria- remain understudied. Here, we show gut virome changes associated with metabolic syndrome (MetS), a highly prevalent clinical condition preceding cardiometabolic disease, in 196 participants by combined sequencing of bulk whole genome and virus like particle communities. MetS gut viromes exhibit decreased richness and diversity. They are enriched in phages infecting Streptococcaceae and Bacteroidaceae and depleted in those infecting Bifidobacteriaceae. Differential abundance analysis identifies eighteen viral clusters (VCs) as significantly associated with either MetS or healthy viromes. Among these are a MetS-associated Roseburia VC that is related to healthy control-associated Faecalibacterium and Oscillibacter VCs. Further analysis of these VCs revealed the Candidatus Heliusviridae, a highly widespread gut phage lineage found in 90+% of participants. The identification of the temperate Ca. Heliusviridae provides a starting point to studies of phage effects on gut bacteria and the role that this plays in MetS.
(© 2022. The Author(s).)
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تواريخ الأحداث: Date Created: 20220623 Date Completed: 20220627 Latest Revision: 20221114
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9226167
DOI: 10.1038/s41467-022-31390-5
PMID: 35739117
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-022-31390-5