دورية أكاديمية
Targeting the Tumor Microenvironment in Acute Myeloid Leukemia: The Future of Immunotherapy and Natural Products.
العنوان: | Targeting the Tumor Microenvironment in Acute Myeloid Leukemia: The Future of Immunotherapy and Natural Products. |
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المؤلفون: | Hino C; Department of Internal Medicine, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA., Pham B; Department of Internal Medicine, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA., Park D; Department of Internal Medicine, School of Medicine, University of California San Francisco-Fresno, Fresno, CA 93701, USA., Yang C; Department of Internal Medicine, School of Medicine, University of California Riverside, Riverside, CA 92521, USA., Nguyen MHK; Department of Oncology/Hematology, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA., Kaur S; Department of Oncology/Hematology, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA., Reeves ME; Department of Oncology/Hematology, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA., Xu Y; Department of Oncology/Hematology, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA., Nishino K; Department of Internal Medicine, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA., Pu L; Department of Internal Medicine, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA., Kwon SM; Department of Internal Medicine, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA., Zhong JF; Department of Basic Sciences, Loma Linda University, Loma Linda, CA 92354, USA., Zhang KK; Department of Nutrition, Texas A&M University, College Station, TX 77030, USA.; Center for Epigenetics & Disease Prevention, Institute of Biosciences & Technology, College of Medicine, Texas A&M University, Houston, TX 77030, USA., Xie L; Department of Nutrition, Texas A&M University, College Station, TX 77030, USA.; Center for Epigenetics & Disease Prevention, Institute of Biosciences & Technology, College of Medicine, Texas A&M University, Houston, TX 77030, USA., Chong EG; Department of Oncology/Hematology, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA., Chen CS; Department of Oncology/Hematology, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA., Nguyen V; Department of Biology, University of California Riverside, Riverside, CA 92521, USA., Castillo DR; Department of Oncology/Hematology, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA., Cao H; Department of Oncology/Hematology, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA. |
المصدر: | Biomedicines [Biomedicines] 2022 Jun 14; Vol. 10 (6). Date of Electronic Publication: 2022 Jun 14. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101691304 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9059 (Print) Linking ISSN: 22279059 NLM ISO Abbreviation: Biomedicines Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI AG, [2013]- |
مستخلص: | The tumor microenvironment (TME) plays an essential role in the development, proliferation, and survival of leukemic blasts in acute myeloid leukemia (AML). Within the bone marrow and peripheral blood, various phenotypically and functionally altered cells in the TME provide critical signals to suppress the anti-tumor immune response, allowing tumor cells to evade elimination. Thus, unraveling the complex interplay between AML and its microenvironment may have important clinical implications and are essential to directing the development of novel targeted therapies. This review summarizes recent advancements in our understanding of the AML TME and its ramifications on current immunotherapeutic strategies. We further review the role of natural products in modulating the TME to enhance response to immunotherapy. |
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فهرسة مساهمة: | Keywords: acute myeloid leukemia; immunotherapy; natural products; tumor microenvironment |
تواريخ الأحداث: | Date Created: 20220624 Latest Revision: 20220716 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC9219790 |
DOI: | 10.3390/biomedicines10061410 |
PMID: | 35740430 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2227-9059 |
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DOI: | 10.3390/biomedicines10061410 |