دورية أكاديمية
أعرض في EDS

Investigation of Dombrock Blood Group Alleles and Genotypes among Saudi Blood Donors in Southwestern Saudi Arabia.

التفاصيل البيبلوغرافية
العنوان: Investigation of Dombrock Blood Group Alleles and Genotypes among Saudi Blood Donors in Southwestern Saudi Arabia.
المؤلفون: Halawani AJ; Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 24381, Saudi Arabia., Mansor AS; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Jazan University, Jazan 82911, Saudi Arabia.; SMIRES for Consultation in Specialized Medical Laboratories, Jazan University, Jazan 82911, Saudi Arabia., Assaggaf HM; Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 24381, Saudi Arabia., Almasmoum HA; Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 24381, Saudi Arabia., Abu-Tawil HI; Department of Laboratory and Blood Bank, Prince Mohammed bin Nasser Hospital, Ministry of Health, Jazan 82943, Saudi Arabia.; Department of Laboratory and Blood Bank, King Faisal Medical City for Southern Regions, Ministry of Health, Abha 62523, Saudi Arabia., Alsharif KF; Department of Clinical Laboratory Science, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia., Dobie G; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Jazan University, Jazan 82911, Saudi Arabia., Habibullah MM; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Jazan University, Jazan 82911, Saudi Arabia.; SMIRES for Consultation in Specialized Medical Laboratories, Jazan University, Jazan 82911, Saudi Arabia.
المصدر: Genes [Genes (Basel)] 2022 Jun 17; Vol. 13 (6). Date of Electronic Publication: 2022 Jun 17.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551097 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4425 (Electronic) Linking ISSN: 20734425 NLM ISO Abbreviation: Genes (Basel) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مواضيع طبية MeSH: Blood Donors* , Blood Group Antigens*/genetics, Alleles ; Genotype ; Humans ; Saudi Arabia/epidemiology
مستخلص: The Dombrock (DO) blood group system has two primary antigens, Do a and Do b , which can cause delayed hemolytic transfusion reactions. The paucity of specific monospecific antibodies can hamper the typing based on these antigens. Thus, blood group genotyping (BGG) was investigated as a possible solution. Sequence-specific primers were designed to target a single nucleotide polymorphism (rs11276) on the ART4 gene encoding the DO*A and DO*B alleles. Blood samples ( n = 150) from randomly selected volunteer donors were used. DNA was extracted and resulting PCR products were purified and sequenced. The allelic frequencies of DO*A and DO*B were ( n = 122, 40.67%) and ( n = 178, 59.33%), respectively. The distributions of DO genotypes were as follows: DO*A / DO*A ( n = 20), 13.33%; DO*B / DO*B ( n = 48), 32.00%; and DO*A / DO*B ( n = 82), 54.67%. In conclusion, this study reports on the allelic frequencies of DO*A and DO*B of the DO blood group system in Jazan Province, Kingdom of Saudi Arabia. Furthermore, this study reports on the prevalence of each genotype, of which DO*A/DO*B was the most abundant. This study contributes significantly to build the current blood donor database in Southwestern Saudi Arabia. Moreover, it may assist in providing safe blood to polytransfused patients and reduce the risk of the red cell alloimmunization.
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فهرسة مساهمة: Keywords: Dombrock blood group; Saudi Arabia; blood group genotyping; blood groups; blood transfusion
المشرفين على المادة: 0 (Blood Group Antigens)
تواريخ الأحداث: Date Created: 20220624 Date Completed: 20220627 Latest Revision: 20220924
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9222856
DOI: 10.3390/genes13061079
PMID: 35741842
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4425
DOI:10.3390/genes13061079