دورية أكاديمية
أعرض في EDS

Manganese and Lead Exposure and Early Puberty Onset in Children Living near a Ferromanganese Alloy Plant.

التفاصيل البيبلوغرافية
العنوان: Manganese and Lead Exposure and Early Puberty Onset in Children Living near a Ferromanganese Alloy Plant.
المؤلفون: Dos Santos NR; Laboratory of Toxicology, College of Pharmacy, Federal University of Bahia, Salvador 40170-110, Brazil.; Graduate Program in Pharmacy, College of Pharmacy, Federal University of Bahia, Salvador 40170-110, Brazil., Rodrigues JLG; Graduate Program in Pharmacy, College of Pharmacy, Federal University of Bahia, Salvador 40170-110, Brazil., Bandeira MJ; Graduate Program in Pharmacy, College of Pharmacy, Federal University of Bahia, Salvador 40170-110, Brazil., Anjos ALDS; Laboratory of Toxicology, College of Pharmacy, Federal University of Bahia, Salvador 40170-110, Brazil., Araújo CFDS; Environmental and Public Health Program, National School of Public Health, Oswald Cruz Foundation, Rio de Janeiro 21041-210, Brazil., Adan LFF; Graduate Program in Medicine and Health, College of Medicine, Federal University of Bahia, Salvador 40170-110, Brazil., Menezes-Filho JA; Laboratory of Toxicology, College of Pharmacy, Federal University of Bahia, Salvador 40170-110, Brazil.; Graduate Program in Pharmacy, College of Pharmacy, Federal University of Bahia, Salvador 40170-110, Brazil.
المصدر: International journal of environmental research and public health [Int J Environ Res Public Health] 2022 Jun 10; Vol. 19 (12). Date of Electronic Publication: 2022 Jun 10.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238455 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-4601 (Electronic) Linking ISSN: 16604601 NLM ISO Abbreviation: Int J Environ Res Public Health Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI, c2004-
مواضيع طبية MeSH: Manganese* , Puberty, Precocious*/chemically induced , Puberty, Precocious*/epidemiology, Alloys ; Child ; Environmental Exposure/analysis ; Female ; Humans ; Ions/analysis ; Iron ; Lead/analysis ; Male ; Puberty
مستخلص: Manganese (Mn) and lead (Pb) have been associated with the deregulation of the neuroendocrine system, which could potentially favor the appearance of precocious puberty (PP) in environmentally exposed children. This study aims to evaluate the exposure to Mn and Pb and their potential effects in anticipating puberty in school-aged children living near a ferromanganese alloy plant in Bahia, Brazil. Toenail, occipital hair and blood samples were collected from 225 school-aged children. Tanner’s scale was used for pubertal staging. Mn in blood (MnB), toenail (MnTn) and hair (MnH) and blood lead (PbB) levels were measured by graphite furnace atomic absorption spectrometry. Puberty-related hormone concentrations were determined by chemiluminescence. The age at which girls’ breasts began to develop was inversely correlated with weight-for-age, height-for-age and BMI-for-age Z-scores (p < 0.05); pubarche also had similar results. Mn biomarker levels did not present differences among pubertal classification nor among children with potential PP or not. Furthermore, Mn exposure was not associated with the age of onset of sexual characteristics for either girls or boys. However, PbB levels were positively correlated with boys’ pubic hair stages (rho = 0.258; p = 0.009) and associated with the age of onset of girls’ pubarche (β = 0.299, 95%CI = 0.055−0.542; p = 0.017). Testosterone and LH concentrations were statistically higher in boys with an increased PbB (p = 0.09 and p = 0.02, respectively). Prospective studies are needed to better assess the association between exposure to Mn and Pb and the early onset of puberty.
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فهرسة مساهمة: Keywords: blood lead; children; early puberty; environmental exposure; manganese
المشرفين على المادة: 0 (Alloys)
0 (Ions)
0 (ferro-manganese alloy)
2P299V784P (Lead)
42Z2K6ZL8P (Manganese)
E1UOL152H7 (Iron)
تواريخ الأحداث: Date Created: 20220624 Date Completed: 20220627 Latest Revision: 20231105
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9222911
DOI: 10.3390/ijerph19127158
PMID: 35742410
قاعدة البيانات: MEDLINE
الوصف
تدمد:1660-4601
DOI:10.3390/ijerph19127158