دورية أكاديمية
Evaluation of Toxic Properties of New Glycopeptide Flavancin on Rats.
العنوان: | Evaluation of Toxic Properties of New Glycopeptide Flavancin on Rats. |
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المؤلفون: | Treshchalin MI; Gause Institute of New Antibiotics, 11 B. Pirogovskaya Street, 119021 Moscow, Russia., Polozkova VA; Gause Institute of New Antibiotics, 11 B. Pirogovskaya Street, 119021 Moscow, Russia., Moiseenko EI; Gause Institute of New Antibiotics, 11 B. Pirogovskaya Street, 119021 Moscow, Russia., Treshalina HM; Gause Institute of New Antibiotics, 11 B. Pirogovskaya Street, 119021 Moscow, Russia., Shchekotikhin AE; Gause Institute of New Antibiotics, 11 B. Pirogovskaya Street, 119021 Moscow, Russia.; Organic Chemistry Department, Mendeleyev University of Chemical Technology of Russia, 9 Miusskaya Square, 125047 Moscow, Russia., Pereverzeva ER; Gause Institute of New Antibiotics, 11 B. Pirogovskaya Street, 119021 Moscow, Russia. |
المصدر: | Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2022 May 25; Vol. 15 (6). Date of Electronic Publication: 2022 May 25. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238453 Publication Model: Electronic Cited Medium: Print ISSN: 1424-8247 (Print) Linking ISSN: 14248247 NLM ISO Abbreviation: Pharmaceuticals (Basel) Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, c2004- |
مستخلص: | Glycopeptide antibiotics have side effects that limit their clinical use. In view of this, the development of glycopeptides with improved chemotherapeutic properties remains the main direction in the search for new antibacterial drugs. The objective of this study was to evaluate the toxicological characteristics of new semi-synthetic glycopeptide flavancin. Acute and chronic toxicity of antibiotic was evaluated in Wistar rats. The medium lethal dose (LD |
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فهرسة مساهمة: | Keywords: acute toxicity; chronic toxicity; eremomycin; flavancin; rats; semi-synthetic glycopeptide antibiotics; vancomycin |
تواريخ الأحداث: | Date Created: 20220624 Latest Revision: 20220716 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC9228439 |
DOI: | 10.3390/ph15060661 |
PMID: | 35745578 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1424-8247 |
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DOI: | 10.3390/ph15060661 |