دورية أكاديمية
أعرض في EDS

Chinese herbal medicine for children with idiopathic short stature (ISS): A systematic review and meta-analysis.

التفاصيل البيبلوغرافية
العنوان: Chinese herbal medicine for children with idiopathic short stature (ISS): A systematic review and meta-analysis.
المؤلفون: Li Y; 2nd Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China., Chen X; Department of Pediatrics, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China.; Lingnan Pediatrics Wen Ziyuan School Studio of Traditional Chinese Medicine, Guangzhou, Guangdong, China.; Luo Xiaorong National Famous Traditional Chinese Medicine Expert Inheritance Studio Guangdong, Guangzhou, Guangdong, China., Liu Z; 2nd Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China., Yang J; Department of Pediatrics, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China.; Lingnan Pediatrics Wen Ziyuan School Studio of Traditional Chinese Medicine, Guangzhou, Guangdong, China.; Luo Xiaorong National Famous Traditional Chinese Medicine Expert Inheritance Studio Guangdong, Guangzhou, Guangdong, China.
المصدر: PloS one [PLoS One] 2022 Jun 24; Vol. 17 (6), pp. e0270511. Date of Electronic Publication: 2022 Jun 24 (Print Publication: 2022).
نوع المنشور: Journal Article; Meta-Analysis; Systematic Review
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Drugs, Chinese Herbal*/therapeutic use, Adult ; Child ; Humans ; Insulin-Like Growth Factor I ; Phytotherapy
مستخلص: Background: Idiopathic short stature (ISS) describes a heterogeneous group of children of many unidentified causes of short stature presently without definitive therapy. Chinese herbal medicine (CHM) is an alternative and complementary treatment for children with ISS and has been widely used for ISS while the evidence of its effectiveness is controversial. We conducted this systematic review and meta-analysis in order to evaluate the efficacy of CHM for ISS.
Methods: PubMed, Embase, Web of science, Sino-Med, Cochrane, CNKI, VIP, and Wangfang Data were electronically searched to collect randomized controlled trials (RCTs) of CHM treatment of ISS from inception to May 2021. Two researchers independently scanned the literature and extracted information on general characteristics, including patient, study design, interventions, and side effects, assessing the CHM intervention's efficacy and the risk of bias. Height, bone age, growth velocity, and IGF-1 level are the main consequences. Height standard deviations score (HtSDS), change in HtSDS (ΔHtSDS), osteocalcin, the peak level of growth hormones (GHP), and predicted adult height (PAH) are the secondary outcomes. Meta-analysis was then performed by using RevMan 5.3 (Cochrane Collaboration).
Results: Seven articles (569 participants) were included. The Meta-analysis indicated that herbal medicine was associated with increased height (MD 2.16 points; 95%CI, 0.22 to 4.10; P = 0.03), growth velocity (MD 1.47 points; 95%CI, 0.28 to 2.67; P = 0.02), IGF-1 level (MD 28.13 points; 95%CI, 22.80 to 33.46; P<0.00001) and GHP (MD 3.29 points; 95%CI, 1.54 to 5.04; P = 0.0002).
Conclusion: According to current research, CHM appears to be useful for children with ISS. Due to the limited quality and number of studies included, more high-quality studies are needed to corroborate the above conclusions.
Competing Interests: The authors have declared that no competing interests exist.
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المشرفين على المادة: 0 (Drugs, Chinese Herbal)
67763-96-6 (Insulin-Like Growth Factor I)
تواريخ الأحداث: Date Created: 20220624 Date Completed: 20220628 Latest Revision: 20220719
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9232169
DOI: 10.1371/journal.pone.0270511
PMID: 35749540
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0270511