دورية أكاديمية
أعرض في EDS

Shared genetic basis between reproductive behaviors and anxiety-related disorders.

التفاصيل البيبلوغرافية
العنوان: Shared genetic basis between reproductive behaviors and anxiety-related disorders.
المؤلفون: Ohi K; Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan. k_ohi@gifu-u.ac.jp.; Department of General Internal Medicine, Kanazawa Medical University, Ishikawa, Japan. k_ohi@gifu-u.ac.jp., Kuramitsu A; Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan., Fujikane D; Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan., Takai K; Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan., Sugiyama S; Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan., Shioiri T; Department of Psychiatry, Gifu University Graduate School of Medicine, Gifu, Japan.
المصدر: Molecular psychiatry [Mol Psychiatry] 2022 Oct; Vol. 27 (10), pp. 4103-4112. Date of Electronic Publication: 2022 Jun 24.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Publication: 2000- : Houndmills, Basingstoke, UK : Nature Publishing Group Specialist Journals
Original Publication: Houndmills, Hampshire, UK ; New York, NY : Stockton Press, c1996-
مواضيع طبية MeSH: Genome-Wide Association Study* , Obsessive-Compulsive Disorder*/genetics , Obsessive-Compulsive Disorder*/psychology, Female ; Humans ; Anxiety Disorders/genetics ; Anxiety Disorders/psychology ; Diagnostic and Statistical Manual of Mental Disorders ; Anxiety/genetics
مستخلص: Reproductive behaviors are associated with risks for psychiatric disorders. Reproductive phenotypes are moderately heritable and have genetic overlaps with risks for psychiatric disorders. However, the genetic and causal relationships between anxiety-related disorders or specific anxiety disorders and reproductive phenotypes remain unknown. We utilized large-scale genome-wide association study (GWAS) results (n = 9537-542,901) for five reproductive phenotypes [age at menarche, age at first sexual intercourse (AFS), age at first birth (AFB), number of children ever born (NEB), and age at menopause] and five anxiety-related disorders [panic disorder, anxiety disorders from the ANGST and the UK biobank (UKBB), posttraumatic stress disorder (PTSD) and obsessive-compulsive disorder (OCD)]. To assess genetic correlations and causal associations, linkage disequilibrium score regression and Mendelian randomization analyses, respectively, were performed. We found that AFS and AFB were negatively correlated with anxiety disorders ANGST (AFS: r g  ± SE = -0.28 ± 0.08, p = 6.00 × 10 -4 ; AFB: -0.45 ± 0.11, p = 3.26 × 10 -5 ), anxiety disorders UKBB (AFS: -0.18 ± 0.03, p = 9.64 × 10 -9 ; AFB; -0.25 ± 0.03, p = 2.90 × 10 -13 ) and PTSD (AFS: -0.42 ± 0.12, p = 4.00 × 10 -4 ; AFB: -0.44 ± 0.12, p = 2.00 × 10 -4 ) and positively correlated with OCD (AFS: 0.25 ± 0.05, p = 2.46 × 10 -6 ; AFB: 0.25 ± 0.05, p = 3.92 × 10 -7 ). Conversely, NEB was negatively correlated with OCD (-0.28 ± 0.08, p = 6.00 × 10 -4 ). We revealed bidirectional effects between earlier AFS and AFB and anxiety disorders (odds ratios: OR earlier AFS→Anxiety  = 1.64, p = 2.27 × 10 -8 ; OR earlier AFB→Anxiety  = 1.15, p = 2.28 × 10 -3 ; OR Anxiety→earlier AFS  = 1.02, p = 6.62 × 10 -8 ; OR Anxiety→earlier AFB  = 1.08, p = 1.60 × 10 -4 ). In contrast, we observed unidirectional effects of later AFS and AFB on OCD (OR later AFS→OCD  = 2.18, p = 2.16 × 10 -6 ; OR later AFB→OCD  = 1.22, p = 0.016). We suggest that those who have earlier sexual debut and childbirth are prone to risk for anxiety disorders and vice versa, while those who have later sexual debut and childbirth are genetically prone to risk for OCD. Our findings further support revising the diagnostic criteria (DSM-5) such that OCD is independent from anxiety disorders.
(© 2022. The Author(s), under exclusive licence to Springer Nature Limited.)
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معلومات مُعتمدة: MC_PC_17228 United Kingdom MRC_ Medical Research Council; MC_QA137853 United Kingdom MRC_ Medical Research Council
تواريخ الأحداث: Date Created: 20220624 Date Completed: 20221206 Latest Revision: 20230407
رمز التحديث: 20231215
DOI: 10.1038/s41380-022-01667-8
PMID: 35750798
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-5578
DOI:10.1038/s41380-022-01667-8