دورية أكاديمية
أعرض في EDS

Cytotoxic and antiparasitic activities of diphosphine-metal complexes of group 10 containing acylthiourea as ligands.

التفاصيل البيبلوغرافية
العنوان: Cytotoxic and antiparasitic activities of diphosphine-metal complexes of group 10 containing acylthiourea as ligands.
المؤلفون: de Oliveira TD; Departamento de Química, Universidade Federal de São Carlos - UFSCar, 3561-901 São Carlos, SP, Brazil. Electronic address: tamires_tdo@hotmail.com., Ribeiro GH; Departamento de Química, Universidade Federal de São Carlos - UFSCar, 3561-901 São Carlos, SP, Brazil., Honorato J; Departamento de Química, Universidade Federal de São Carlos - UFSCar, 3561-901 São Carlos, SP, Brazil., Leite CM; Departamento de Química, Universidade Federal de São Carlos - UFSCar, 3561-901 São Carlos, SP, Brazil., Santos ACDS; Fundação Oswaldo Cruz (Fiocruz-Pernambuco), Instituto Aggeu Magalhães, 50670-420 Recife, Pernambuco, Brazil., Silva ED; Fundação Oswaldo Cruz (Fiocruz-Pernambuco), Instituto Aggeu Magalhães, 50670-420 Recife, Pernambuco, Brazil., Pereira VRA; Fundação Oswaldo Cruz (Fiocruz-Pernambuco), Instituto Aggeu Magalhães, 50670-420 Recife, Pernambuco, Brazil., Plutín AM; Laboratório de Síntesis Orgánica, Facultad de Química, Universidad de La Habana - UH, 10400 Habana, Cuba., Cominetti MR; Departamento de Gerontologia, Universidade Federal de São Carlos - UFSCar, 3561-901 São Carlos, SP, Brazil., Castellano EE; Instituto de Física de São Carlos, Universidade de São Paulo - USP, 13560-970 São Carlos, SP, Brazil., Batista AA; Departamento de Química, Universidade Federal de São Carlos - UFSCar, 3561-901 São Carlos, SP, Brazil. Electronic address: daab@ufscar.br.
المصدر: Journal of inorganic biochemistry [J Inorg Biochem] 2022 Sep; Vol. 234, pp. 111906. Date of Electronic Publication: 2022 Jun 20.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 7905788 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3344 (Electronic) Linking ISSN: 01620134 NLM ISO Abbreviation: J Inorg Biochem Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, Elsevier.
مواضيع طبية MeSH: Antineoplastic Agents*/chemistry , Breast Neoplasms* , Coordination Complexes*/chemistry, Antiparasitic Agents/pharmacology ; Cell Line, Tumor ; Female ; Humans ; Ligands ; Thiourea/pharmacology
مستخلص: In this work, group 10 transition metal complexes bearing dppe [1,2-bis(diphenylphosphino)ethane] and acylthiourea ligands were evaluated for their cytotoxic and antiparasitic activities. Six new complexes with a general formula [M(L n )(dppe)]BF 4 [where M = Ni II , Pd II or Pt II ; L n  = N, N'-dimethyl-N-benzoyl thiourea (L 1 ) or N, N'-dimethyl-N-tiofenyl thiourea (L 2 ) were synthesized and characterized by infrared, NMR ( 31 P{ 1 H}, 1 H and 13 C{ 1 H}) spectroscopies, elemental analysis and molar conductivity. The structures of the complexes were confirmed by X-ray diffraction technique. The biological activity of the complexes was evaluated on breast cancer cells (MDA-MB-231 and MCF-7) and causative agents of chagas disease and leishmaniasis. The complexes presented higher cytotoxicity for breast cancer cell lines compared to non-tumor cells. Nickel complexes stood out when evaluated against the triple-negative breast cancer line (MDA-MB-231), presenting considerably lower IC 50 values (about 10 to 22×), when compared to palladium and platinum complexes, and the cisplatin drug. When evaluated on the triple-negative line (MDA-MB-231), the complexes [Ni(L 2 )(dppe)]BF 4 (2), [Pd(L 2 )(dppe)]BF 4 (4) and [Pt(L 2 )(dppe)]BF 4 (6) were able to induce cell morphological changes, influence on the cell colony formation and the size of the cells. The complexes inhibit cell migration and cause changes to the cell cytoskeleton and nuclear arrangement. In the same cell line, the compounds caused cell arrest in the Sub-G1 phase of the cell cycle. The compounds were also tested against the Trypanosom Cruzi (T. cruzi) and Leishmania sp. parasites, which cause Chagas and leishmaniasis disease, respectively. The compounds showed good anti-parasitic activity, mainly for T. cruzi, with lower IC 50 values, when compared to the commercial drug, benznidazole. The compounds interact with CT-DNA, indicating that interaction occurs by the minor groove of the biomolecule.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Acylthiourea; Breast cancer; Chagas disease; Leishmaniasis; Metal complexes; Phosphine
المشرفين على المادة: 0 (Antineoplastic Agents)
0 (Antiparasitic Agents)
0 (Coordination Complexes)
0 (Ligands)
GYV9AM2QAG (Thiourea)
تواريخ الأحداث: Date Created: 20220627 Date Completed: 20220712 Latest Revision: 20221022
رمز التحديث: 20231215
DOI: 10.1016/j.jinorgbio.2022.111906
PMID: 35759891
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-3344
DOI:10.1016/j.jinorgbio.2022.111906