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Variation in mitochondrial DNA affects locomotor activity and sleep in Drosophila melanogaster.

التفاصيل البيبلوغرافية
العنوان: Variation in mitochondrial DNA affects locomotor activity and sleep in Drosophila melanogaster.
المؤلفون: Anderson L; Institute of Ecology and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, UK., Camus MF; Research Department of Genetics, Evolution and Environment, University College London, Gower Street, London, WC1E 6BT, UK., Monteith KM; Institute of Ecology and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, UK., Salminen TS; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Vale PF; Institute of Ecology and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, UK. pedro.vale@ed.ac.uk.
المصدر: Heredity [Heredity (Edinb)] 2022 Oct; Vol. 129 (4), pp. 225-232. Date of Electronic Publication: 2022 Jun 28.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0373007 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2540 (Electronic) Linking ISSN: 0018067X NLM ISO Abbreviation: Heredity (Edinb) Subsets: MEDLINE
أسماء مطبوعة: Publication: <2003->: London : Nature Publishing Group
Original Publication: London, Oliver and Boyd.
مواضيع طبية MeSH: DNA, Mitochondrial*/genetics , Drosophila melanogaster*/genetics, Adenosine Triphosphate/metabolism ; Animals ; Drosophila/genetics ; Female ; Locomotion/genetics ; Male ; Mitochondria/genetics ; Sleep/genetics
مستخلص: Mitochondria are organelles that produce cellular energy in the form of ATP through oxidative phosphorylation, and this primary function is conserved among many taxa. Locomotion is a trait that is highly reliant on metabolic function and expected to be greatly affected by disruptions to mitochondrial performance. To this end, we aimed to examine how activity and sleep vary between Drosophila melanogaster strains with different geographic origins, how these patterns are affected by mitochondrial DNA (mtDNA) variation, and how breaking up co-evolved mito-nuclear gene combinations affect the studied activity traits. Our results demonstrate that Drosophila strains from different locations differ in sleep and activity, and that females are generally more active than males. By comparing activity and sleep of mtDNA variants introgressed onto a common nuclear background in cytoplasmic hybrid (cybrid) strains, we were able to quantify the among-line variance attributable to mitochondrial DNA, and we establish that mtDNA variation affects both activity and sleep, in a sex-specific manner. Altogether our study highlights the important role that mitochondrial genome variation plays on organismal physiology and behaviour.
(© 2022. The Author(s).)
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المشرفين على المادة: 0 (DNA, Mitochondrial)
8L70Q75FXE (Adenosine Triphosphate)
تواريخ الأحداث: Date Created: 20220628 Date Completed: 20220930 Latest Revision: 20221110
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9519576
DOI: 10.1038/s41437-022-00554-w
PMID: 35764697
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-2540
DOI:10.1038/s41437-022-00554-w