دورية أكاديمية
أعرض في EDS

Assessing salivary matrix metalloproteinase-8 in prostate cancer patients undergoing androgen deprivation therapy.

التفاصيل البيبلوغرافية
العنوان: Assessing salivary matrix metalloproteinase-8 in prostate cancer patients undergoing androgen deprivation therapy.
المؤلفون: Memon MA; Institute of Pathology and Diagnostic Medicine, Khyber Medical University, Peshawar, Pakistan., Aleem B; Institute of Pathology and Diagnostic Medicine, Khyber Medical University, Peshawar, Pakistan., Memon HA; Dow University of Health Sciences, Karachi, Pakistan., Lee KY; Department of Health Sciences, Swedish Winter Sports Research Centre, Mid Sweden University, Östersund, Sweden.
المصدر: Clinical and experimental dental research [Clin Exp Dent Res] 2022 Oct; Vol. 8 (5), pp. 1277-1283. Date of Electronic Publication: 2022 Jun 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 101692332 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2057-4347 (Electronic) Linking ISSN: 20574347 NLM ISO Abbreviation: Clin Exp Dent Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Hoboken : Wiley, [2015]-
مواضيع طبية MeSH: Periodontitis*/therapy , Prostatic Neoplasms*/drug therapy, Androgen Antagonists/therapeutic use ; Androgens ; Biomarkers ; Collagen ; Humans ; Male ; Matrix Metalloproteinase 8
مستخلص: Introduction: Matrix metalloproteinase-8 (MMP-8) is considered as one of the most promising diagnostic markers for periodontal disease. Androgen deprivation therapy (ADT) has been correlated with impaired collagen synthesis and an increase in periodontal tissue susceptibility to pathogenic microorganisms.
Objective: This study aims to investigate the impact of ADT on salivary MMP-8 level and periodontal parameters, which might be useful in monitoring periodontal disease in prostate cancer patients undergoing ADT.
Materials and Methods: A total of 88 subjects were selected and were divided into two groups: Group I included n = 78 PC patients who have been undergoing ADT); Group II included n = 10 healthy individuals. Periodontal parameters such as plaque index (PI), gingival index (GI), periodontal probing depth (PPD), and clinical attachment level (CAL) were examined. The salivary MMP-8 level was estimated by using the sandwich enzyme-linked immunosorbent assay method.
Results: Significant differences in mean salivary MMP-8 level were found between PC patients undergoing ADT and healthy individuals. Salivary MMP-8 levels of all individuals were positively correlated with GI, PI, PPD, and CAL. Salivary MMP-8 can distinguish between periodontitis and healthy individuals with an accuracy of about 80%.
Conclusion: Salivary MMP-8 levels were found to be higher in prostate cancer patients undergoing ADT compared to healthy individuals.
(© 2022 The Authors. Clinical and Experimental Dental Research published by John Wiley & Sons Ltd.)
References: Expert Rev Mol Med. 2013 Aug 05;15:e7. (PMID: 23915822)
Clin Chim Acta. 2013 Jun 5;421:140-6. (PMID: 23501330)
CA Cancer J Clin. 2021 May;71(3):209-249. (PMID: 33538338)
Medicine (Baltimore). 2018 Jan;97(3):e9642. (PMID: 29504999)
Biochem Med (Zagreb). 2021 Feb 15;31(1):010502. (PMID: 33380887)
J Urol. 2003 Dec;170(6 Pt 2):S59-63; discussion S64. (PMID: 14610412)
Int J Mol Sci. 2017 Feb 17;18(2):. (PMID: 28218665)
Int J Environ Res Public Health. 2020 Jul 08;17(14):. (PMID: 32650590)
BMC Oral Health. 2018 Mar 27;18(1):51. (PMID: 29587716)
Clin Exp Dent Res. 2022 Oct;8(5):1277-1283. (PMID: 35769040)
J Clin Periodontol. 2014 May;41(5):442-50. (PMID: 24460823)
J Urol. 2002 May;167(5):1952-6. (PMID: 11956415)
Med J Aust. 2004 Mar 15;180(6):298-303. (PMID: 15012571)
Diagnostics (Basel). 2021 Aug 20;11(8):. (PMID: 34441437)
J Periodontol. 2009 Mar;80(3):436-46. (PMID: 19254128)
J Periodontal Res. 2012 Feb;47(1):121-8. (PMID: 21958332)
Periodontol 2000. 2009;50:52-64. (PMID: 19388953)
Oral Dis. 2016 Oct;22(7):681-7. (PMID: 27273425)
J Periodontol. 2014 Feb;85(2):250-60. (PMID: 23659421)
Eur J Oral Sci. 2016 Oct;124(5):447-453. (PMID: 27671982)
J Periodontal Res. 2022 Jun;57(3):558-567. (PMID: 35304757)
Front Cell Infect Microbiol. 2015 Aug 19;5:62. (PMID: 26347856)
BMC Med Res Methodol. 2017 Apr 7;17(1):53. (PMID: 28388943)
Clin Chem. 1993 Apr;39(4):561-77. (PMID: 8472349)
Front Med. 2015 Mar;9(1):72-6. (PMID: 25098434)
Ann N Y Acad Sci. 1993 Sep 20;694:72-7. (PMID: 8215087)
Periodontol 2000. 2003;32:9-10. (PMID: 12756029)
J Clin Med. 2020 Jun 03;9(6):. (PMID: 32503210)
Urology. 1999 Oct;54(4):607-11. (PMID: 10510915)
J Urol. 2007 Mar;177(3):921-4. (PMID: 17296376)
Cells. 2020 Apr 26;9(5):. (PMID: 32357580)
Oral Dis. 2014 Sep;20(6):538-50. (PMID: 23849049)
Diagnostics (Basel). 2020 Jan 22;10(2):. (PMID: 31979091)
J Am Dent Assoc. 2006 Mar;137(3):322-9. (PMID: 16570465)
فهرسة مساهمة: Keywords: MMP-8; androgen antagonists; biomarker; periodontal diseases; saliva
المشرفين على المادة: 0 (Androgen Antagonists)
0 (Androgens)
0 (Biomarkers)
9007-34-5 (Collagen)
EC 3.4.24.34 (MMP8 protein, human)
EC 3.4.24.34 (Matrix Metalloproteinase 8)
تواريخ الأحداث: Date Created: 20220630 Date Completed: 20221017 Latest Revision: 20221019
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9562491
DOI: 10.1002/cre2.624
PMID: 35769040
قاعدة البيانات: MEDLINE
الوصف
تدمد:2057-4347
DOI:10.1002/cre2.624