دورية أكاديمية
SARS-CoV-2 Seroconversion in Response to Infection and Vaccination: a Time Series Local Study in Brazil.
| العنوان: | SARS-CoV-2 Seroconversion in Response to Infection and Vaccination: a Time Series Local Study in Brazil. |
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| المؤلفون: | Huergo LF; Setor Litoral, UFPR Matinhos, Matinhos, Paraná, Brazil., Paula NM; Setor Litoral, UFPR Matinhos, Matinhos, Paraná, Brazil., Gonçalves ACA; Setor Litoral, UFPR Matinhos, Matinhos, Paraná, Brazil., Kluge CHS; Setor Litoral, UFPR Matinhos, Matinhos, Paraná, Brazil., Marins PHSA; Setor Litoral, UFPR Matinhos, Matinhos, Paraná, Brazil., Camargo HSC; Setor Litoral, UFPR Matinhos, Matinhos, Paraná, Brazil., Sant'Ana TP; Setor Litoral, UFPR Matinhos, Matinhos, Paraná, Brazil., Farias LRP; Setor Litoral, UFPR Matinhos, Matinhos, Paraná, Brazil., Aldrighi JD; Setor Litoral, UFPR Matinhos, Matinhos, Paraná, Brazil., Lima ÊS; Setor Litoral, UFPR Matinhos, Matinhos, Paraná, Brazil., Jacotenski GT; Setor Litoral, UFPR Matinhos, Matinhos, Paraná, Brazil., Vargas LR; Setor Litoral, UFPR Matinhos, Matinhos, Paraná, Brazil., Costa G; Setor Litoral, UFPR Matinhos, Matinhos, Paraná, Brazil., Weissheimer KV; Setor Litoral, UFPR Matinhos, Matinhos, Paraná, Brazil., Nazário MG; Setor Litoral, UFPR Matinhos, Matinhos, Paraná, Brazil., Teixeira KN; Campus Toledo, UFPR Toledo, Toledo, Paraná, Brazil., Conzentino MS; Setor Litoral, UFPR Matinhos, Matinhos, Paraná, Brazil. |
| المصدر: | Microbiology spectrum [Microbiol Spectr] 2022 Aug 31; Vol. 10 (4), pp. e0102622. Date of Electronic Publication: 2022 Jun 30. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: ASM Press Country of Publication: United States NLM ID: 101634614 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2165-0497 (Electronic) Linking ISSN: 21650497 NLM ISO Abbreviation: Microbiol Spectr Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : ASM Press, 2013- |
| مواضيع طبية MeSH: | COVID-19*/epidemiology , COVID-19*/prevention & control , SARS-CoV-2*, Antibodies, Viral ; Brazil/epidemiology ; COVID-19 Vaccines ; Humans ; Immunoglobulin G ; Seroconversion ; Spike Glycoprotein, Coronavirus ; Time Factors ; Vaccination |
| مستخلص: | The investigation of antibodies raised against different severe acute respiratory syndrome coronavirus (SARS-CoV-2) antigens can help to determine the extent of previous SARS-CoV-2 infections in the population and track the humoral response to vaccination. Therefore, serological surveys can provide key information to better manage the pandemic and/or to implement the most effective vaccination program. Here we describe a time series anti-nucleocapsid, anti-spike IgG serological survey analysis in the city of Matinhos, PR, Brazil during the year of 2021. Seroconversion rates to the nucleocapsid antigen were not influenced by gender or age. The serological data support that the coronavirus disease 2019 (COVID-19) infection rate is ~50% higher than official numbers. Furthermore, by applying serological data, the corrected infection fatality rate was estimated to be lower than 2.4% in contrast with the official estimative of 3.6%. The rates of IgG reactive to spike antigen resembled the curve of the fraction the population that had taken the second vaccine dose. Up to 82% of spike seroconversion was detected in the end of 2021, confirming the effectiveness of the COVID-19 vaccination program in the city. This SARS-CoV-2 serological study unraveled the SARS-CoV-2 infection rates and the response to vaccination in the city of Matinhos. IMPORTANCE The investigation of antibodies raised against SARS-CoV-2 can help to determine the extent of previous SARS-CoV-2 infections and track the humoral response to vaccination. Here we describe a time series anti-nucleocapsid, anti-spike IgG serological survey in the city of Matinhos, PR, Brazil during the year of 2021. The data depicted the progression of SARS-CoV-2 infections in the city allowing the correction of the number of citizens who experienced COVID-19 and the disease fatality rate. The seroconversion rates to the spike antigen resembled the curve of the fraction of the population that had taken the second vaccine dose, thereby confirming the effectiveness of the COVID-19 vaccination program in the city. |
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| فهرسة مساهمة: | Keywords: COVID-19; IgG; SARS-CoV-2; nucleocapsid; seroconvertion; seroprevalence; spike; vaccination |
| المشرفين على المادة: | 0 (Antibodies, Viral) 0 (COVID-19 Vaccines) 0 (Immunoglobulin G) 0 (Spike Glycoprotein, Coronavirus) 0 (spike protein, SARS-CoV-2) |
| تواريخ الأحداث: | Date Created: 20220630 Date Completed: 20220908 Latest Revision: 20221011 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9430992 |
| DOI: | 10.1128/spectrum.01026-22 |
| PMID: | 35770982 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2165-0497 |
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| DOI: | 10.1128/spectrum.01026-22 |