دورية أكاديمية
Targeting improved resilience in Merino sheep - Correlations between immune competence and health and fitness traits.
| العنوان: | Targeting improved resilience in Merino sheep - Correlations between immune competence and health and fitness traits. |
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| المؤلفون: | Hine BC; CSIRO Agriculture & Food, F.D. McMaster Laboratory, Chiswick, New England Highway, Armidale, NSW 2350, Australia. Electronic address: brad.hine@csiro.au., Acton GA; CSIRO Agriculture & Food, F.D. McMaster Laboratory, Chiswick, New England Highway, Armidale, NSW 2350, Australia., Elks DJ; CSIRO Agriculture & Food, F.D. McMaster Laboratory, Chiswick, New England Highway, Armidale, NSW 2350, Australia., Niemeyer DDO; CSIRO Agriculture & Food, F.D. McMaster Laboratory, Chiswick, New England Highway, Armidale, NSW 2350, Australia., Bell AM; CSIRO Agriculture & Food, F.D. McMaster Laboratory, Chiswick, New England Highway, Armidale, NSW 2350, Australia., Colditz IG; CSIRO Agriculture & Food, F.D. McMaster Laboratory, Chiswick, New England Highway, Armidale, NSW 2350, Australia., Ingham AB; CSIRO Agriculture & Food, Queensland Bioscience Precinct, 306 Carmody Rd., St. Lucia, Brisbane, QLD 4067, Australia., Smith JL; CSIRO Agriculture & Food, F.D. McMaster Laboratory, Chiswick, New England Highway, Armidale, NSW 2350, Australia. |
| المصدر: | Animal : an international journal of animal bioscience [Animal] 2022 Jul; Vol. 16 (7), pp. 100544. Date of Electronic Publication: 2022 Jun 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 101303270 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1751-732X (Electronic) Linking ISSN: 17517311 NLM ISO Abbreviation: Animal Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : [London] : Elsevier Original Publication: Cambridge, England : Cambridge University Press |
| مواضيع طبية MeSH: | Disease Resistance*, Animals ; Australia ; Phenotype ; Weaning |
| مستخلص: | Resilience can be defined as the ability of an animal to remain productive in the face of diverse environmental challenges. Several factors contribute to an animal's resilience including its ability to resist disease, cope with climatic extremes and respond to stressors. Immune competence, a proxy trait for general disease resistance, is expected to contribute to an animal's resilience. This research aimed to develop a practical method to assess immune competence in Merino sheep which would not restrict the future sale of tested animals, and to estimate genetic parameters associated with the novel trait. We also aimed to explore associations between immune competence and other industry-relevant disease resistance and fitness-related traits and to assess the ability of immune competence phenotypes to predict health outcomes. Here, the ability of Merino wethers (n = 1 339) to mount both an antibody-mediated and cell-mediated immune response was used to define their immune competence phenotype. For that purpose, antigens in a commercial vaccine were administered at the commencement of weaning and their responses were assessed. Univariate sire models were used to estimate variance components and heritabilities for immune competence and its component traits. Bivariate sire models were used to estimate genetic correlations between immune competence and a range of disease resistance and fitness-related traits. The heritability of immune competence and its component traits, antibody-mediated immune response and cell-mediated immune response were estimated at 0.49 ± 0.14, 0.52 ± 0.14 and 0.36 ± 0.11, respectively. Immune competence was favourably genetically correlated with breech flystrike incidence (-0.44 ± 0.39), worm egg count (-0.19 ± 0.23), dag score (-0.26 ± 0.31) and fitness compromise (-0.35 ± 0.24) but not fleece rot (0.17 ± 0.23). Results suggest that selection for immune competence has the potential to improve the resilience of Merino sheep; however, due to the large standard errors associated with correlation estimates reported here, further studies will be required in larger populations to validate associations between immune competence and disease resistance and fitness traits in Australian Merino sheep. (Crown Copyright © 2022. Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Animal health; Animal welfare; Disease resistance; Genetic selection; Immune responsiveness |
| تواريخ الأحداث: | Date Created: 20220701 Date Completed: 20220726 Latest Revision: 20220726 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.animal.2022.100544 |
| PMID: | 35777298 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1751-732X |
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| DOI: | 10.1016/j.animal.2022.100544 |