دورية أكاديمية
Spatial and temporal patterns in dynamic-contrast enhanced intraoperative fluorescence imaging enable classification of bone perfusion in patients undergoing leg amputation.
| العنوان: | Spatial and temporal patterns in dynamic-contrast enhanced intraoperative fluorescence imaging enable classification of bone perfusion in patients undergoing leg amputation. |
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| المؤلفون: | Han X; Thayer School of Engineering, Dartmouth College, 14 Engineering Dr., Hanover, NH 03755, USA.; Contributed equally., Demidov V; Department of Orthopaedics, Dartmouth-Hitchcock Medical Center, Dartmouth Health, 1 Medical Center Dr., Lebanon, NH 03766, USA.; Geisel School of Medicine, Dartmouth College, 1 Rope Ferry Rd, Hanover, NH 03755, USA.; Contributed equally., Vaze VS; Thayer School of Engineering, Dartmouth College, 14 Engineering Dr., Hanover, NH 03755, USA., Jiang S; Thayer School of Engineering, Dartmouth College, 14 Engineering Dr., Hanover, NH 03755, USA., Gitajn IL; Department of Orthopaedics, Dartmouth-Hitchcock Medical Center, Dartmouth Health, 1 Medical Center Dr., Lebanon, NH 03766, USA.; Geisel School of Medicine, Dartmouth College, 1 Rope Ferry Rd, Hanover, NH 03755, USA., Elliott JT; Thayer School of Engineering, Dartmouth College, 14 Engineering Dr., Hanover, NH 03755, USA.; Department of Orthopaedics, Dartmouth-Hitchcock Medical Center, Dartmouth Health, 1 Medical Center Dr., Lebanon, NH 03766, USA.; Geisel School of Medicine, Dartmouth College, 1 Rope Ferry Rd, Hanover, NH 03755, USA. |
| المصدر: | Biomedical optics express [Biomed Opt Express] 2022 May 03; Vol. 13 (6), pp. 3171-3186. Date of Electronic Publication: 2022 May 03 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Optica Publishing Group Country of Publication: United States NLM ID: 101540630 Publication Model: eCollection Cited Medium: Print ISSN: 2156-7085 (Print) Linking ISSN: 21567085 NLM ISO Abbreviation: Biomed Opt Express Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: Washington, DC : Optica Publishing Group Original Publication: Washington, DC : Optical Society of America |
| مستخلص: | Dynamic contrast-enhanced fluorescence imaging (DCE-FI) classification of tissue viability in twelve adult patients undergoing below knee leg amputation is presented. During amputation and with the distal bone exposed, indocyanine green contrast-enhanced images were acquired sequentially during baseline, following transverse osteotomy and following periosteal stripping, offering a uniquely well-controlled fluorescence dataset. An unsupervised classification machine leveraging 21 different spatiotemporal features was trained and evaluated by cross-validation in 3.5 million regions-of-interest obtained from 9 patients, demonstrating accurate stratification into normal, suspicious, and compromised regions. The machine learning (ML) approach also outperformed the standard method of using fluorescence intensity only to evaluate tissue perfusion by a two-fold increase in accuracy. The generalizability of the machine was evaluated in image series acquired in an additional three patients, confirming the stability of the model and ability to sort future patient image-sets into viability categories. Competing Interests: The authors declare no conflicts of interest. (© 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement.) |
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| معلومات مُعتمدة: | R00 CA190890 United States CA NCI NIH HHS |
| تواريخ الأحداث: | Date Created: 20220705 Latest Revision: 20231014 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC9208615 |
| DOI: | 10.1364/BOE.459497 |
| PMID: | 35781962 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2156-7085 |
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| DOI: | 10.1364/BOE.459497 |