دورية أكاديمية
أعرض في EDS

Ghrelin mediated regulation of neurosynaptic transmitters in depressive disorders.

التفاصيل البيبلوغرافية
العنوان: Ghrelin mediated regulation of neurosynaptic transmitters in depressive disorders.
المؤلفون: Masule MV; Department of Pharmacology, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, 425405, Maharashtra, India., Rathod S; Shri Vile Parle Kelavani Mandal's Institute of Pharmacy, Dhule, 424001, Maharashtra, India., Agrawal Y; Shri Vile Parle Kelavani Mandal's Institute of Pharmacy, Dhule, 424001, Maharashtra, India., Patil CR; Department of Pharmacology, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, 425405, Maharashtra, India., Nakhate KT; Shri Vile Parle Kelavani Mandal's Institute of Pharmacy, Dhule, 424001, Maharashtra, India., Ojha S; Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates., Goyal SN; Shri Vile Parle Kelavani Mandal's Institute of Pharmacy, Dhule, 424001, Maharashtra, India., Mahajan UB; Department of Pharmacology, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, 425405, Maharashtra, India.
المصدر: Current research in pharmacology and drug discovery [Curr Res Pharmacol Drug Discov] 2022 Jun 13; Vol. 3, pp. 100113. Date of Electronic Publication: 2022 Jun 13 (Print Publication: 2022).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 9918300982506676 Publication Model: eCollection Cited Medium: Internet ISSN: 2590-2571 (Electronic) Linking ISSN: 25902571 NLM ISO Abbreviation: Curr Res Pharmacol Drug Discov Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam: Elsevier B.V., [2020]-
مستخلص: Ghrelin is a peptide released by the endocrine cells of the stomach and the neurons in the arcuate nucleus of the hypothalamus. It modulates both peripheral and central functions. Although ghrelin has emerged as a potent stimulator of growth hormone release and as an orexigenic neuropeptide, the wealth of literature suggests its involvement in the pathophysiology of affective disorders including depression. Ghrelin exhibits a dual role through the advancement and reduction of depressive behavior with nervousness in the experimental animals. It modulates depression-related signals by forming neuronal networks with various neuropeptides and classical neurotransmitter systems. The present review emphasizes the integration and signaling of ghrelin with other neuromodulatory systems concerning depressive disorders. The role of ghrelin in the regulation of neurosynaptic transmission and depressive illnesses implies that the ghrelin system modulation can yield promising antidepressive therapies.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2022 The Authors.)
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فهرسة مساهمة: Keywords: Depression; GHSR; Ghrelin; Neurotransmitter; Psychotic disorders
تواريخ الأحداث: Date Created: 20220705 Latest Revision: 20220716
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9240712
DOI: 10.1016/j.crphar.2022.100113
PMID: 35782191
قاعدة البيانات: MEDLINE
الوصف
تدمد:2590-2571
DOI:10.1016/j.crphar.2022.100113