دورية أكاديمية
Susceptibility status of major malaria vectors to novaluron, an insect growth regulator South-Eastern Tanzania.
| العنوان: | Susceptibility status of major malaria vectors to novaluron, an insect growth regulator South-Eastern Tanzania. |
|---|---|
| المؤلفون: | Ngonzi AJ; Ifakara Health Institute, Environmental Health and Ecological Science Department, PO Box 53, Ifakara, Tanzania.; The Nelson Mandela African Institution of Science and Technology, Department of Life Science and Bio-Engineering, PO BOX 447, Arusha, Tanzania., Muyaga LL; Ifakara Health Institute, Environmental Health and Ecological Science Department, PO Box 53, Ifakara, Tanzania., Ngowo H; Ifakara Health Institute, Environmental Health and Ecological Science Department, PO Box 53, Ifakara, Tanzania., Urio N; Ifakara Health Institute, Environmental Health and Ecological Science Department, PO Box 53, Ifakara, Tanzania.; The Nelson Mandela African Institution of Science and Technology, Department of Life Science and Bio-Engineering, PO BOX 447, Arusha, Tanzania., Vianney JM; The Nelson Mandela African Institution of Science and Technology, Department of Life Science and Bio-Engineering, PO BOX 447, Arusha, Tanzania., Lwetoijera DW; Ifakara Health Institute, Environmental Health and Ecological Science Department, PO Box 53, Ifakara, Tanzania.; The Nelson Mandela African Institution of Science and Technology, Department of Life Science and Bio-Engineering, PO BOX 447, Arusha, Tanzania. |
| المصدر: | The Pan African medical journal [Pan Afr Med J] 2022 Apr 05; Vol. 41, pp. 273. Date of Electronic Publication: 2022 Apr 05 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: African Field Epidemiology Network Country of Publication: Uganda NLM ID: 101517926 Publication Model: eCollection Cited Medium: Internet ISSN: 1937-8688 (Electronic) NLM ISO Abbreviation: Pan Afr Med J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Kampala, Uganda : African Field Epidemiology Network |
| مواضيع طبية MeSH: | Anopheles* , Malaria*/prevention & control, Animals ; Humans ; Juvenile Hormones/pharmacology ; Larva ; Mosquito Vectors ; Phenylurea Compounds ; Tanzania |
| مستخلص: | Introduction: application of Insect Growth Regulator (IGR) such as pyriproxyfen has shown a promising result in controlling malaria transmitting mosquitoes through autodissemination technique. Novaluron that inhibits the chitin development at mosquito larval stage present a promising candidate IGR for rotation with pyriproxyfen to prevent a chance of resistance development. This study assessed the susceptibility of immature stages of Anopheles arabiensis, Anopheles gambiae and Anopheles funestus to novaluron. Methods: susceptibility bioassays using technical grade novaluron (98% active ingredient) were performed inside the semi-field system using first instar larvae of Anopheles species. For each tested species, a total of 1500 larvae were used in the bioassay. Concentration range of 0.01 mg/l to 2 mg/l of novaluron were tested to establish Lethal Concentration (LC) sufficient to kills 50%, 90% and 99% of the exposed larvae by using log-dose response analysis. Results: of the tested mosquitoes, Anopheles gambiae were highly susceptible to novaluron followed by An. Arabiensis and then An. funestus. Lethal concentrations, LC Conclusion: the study demonstrates the efficacy of novaluron in controlling Anopheles mosquito species at immature stages via larval mortality. These findings warrant further testing of novaluron for autodissemination by different vector species for its inclusion in rotation to prevent development of resistance. Competing Interests: The authors declare no competing interests. (Copyright: Amos Justinian Ngonzi et al.) |
| References: | J Vector Ecol. 2003 Dec;28(2):241-54. (PMID: 14714674) Med Vet Entomol. 2006 Dec;20(4):377-87. (PMID: 17199749) PLoS One. 2012;7(1):e30363. (PMID: 22291942) Malar J. 2009 Dec 30;8:311. (PMID: 20042071) Med Vet Entomol. 2012 Mar;26(1):37-45. (PMID: 21689125) Malar J. 2021 May 31;20(1):244. (PMID: 34059053) Parasit Vectors. 2013 Mar 07;6:57. (PMID: 23497471) Am J Trop Med Hyg. 2001 Jan-Feb;64(1-2 Suppl):85-96. (PMID: 11425181) Malar J. 2021 Mar 12;20(1):148. (PMID: 33712003) Malar J. 2014 Apr 29;13:161. (PMID: 24779515) BMC Infect Dis. 2019 Sep 11;19(1):800. (PMID: 31510931) Med Vet Entomol. 2007 Mar;21(1):2-21. (PMID: 17373942) Am J Trop Med Hyg. 2019 Dec;101(6):1405-1415. (PMID: 31628735) Malar J. 2008 Aug 20;7:158. (PMID: 18715508) J Econ Entomol. 1974 Jun;67(3):329-32. (PMID: 4151972) PLoS One. 2017 May 18;12(5):e0177807. (PMID: 28542335) J Am Mosq Control Assoc. 2014 Dec;30(4):284-90. (PMID: 25843134) PLoS One. 2009;4(3):e5107. (PMID: 19333402) PLoS Negl Trop Dis. 2018 Apr 11;12(4):e0006259. (PMID: 29641515) Cochrane Database Syst Rev. 2013 Aug 29;(8):CD008923. (PMID: 23986463) Malar J. 2019 Jul 17;18(1):243. (PMID: 31315614) Malar J. 2015 Jan 21;14:10. (PMID: 25604997) Insect Biochem Mol Biol. 2016 Nov;78:50-57. (PMID: 27613592) Nature. 2015 Oct 8;526(7572):207-211. (PMID: 26375008) Science. 2017 Nov 24;358(6366):998-999. (PMID: 29170222) Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11530-4. (PMID: 19561295) |
| فهرسة مساهمة: | Keywords: An. arabiensis; An. funestus; An. gambiae; Insect growth regulator; Tanzania; novaluron; susceptibility |
| المشرفين على المادة: | 0 (Juvenile Hormones) 0 (Phenylurea Compounds) Z8H1B3CW0B (novaluron) |
| تواريخ الأحداث: | Date Created: 20220705 Date Completed: 20220706 Latest Revision: 20220716 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC9206179 |
| DOI: | 10.11604/pamj.2022.41.273.33793 |
| PMID: | 35784600 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1937-8688 |
|---|---|
| DOI: | 10.11604/pamj.2022.41.273.33793 |