دورية أكاديمية
Exercise-Induced Circulating microRNAs: Potential Key Factors in the Control of Breast Cancer.
| العنوان: | Exercise-Induced Circulating microRNAs: Potential Key Factors in the Control of Breast Cancer. |
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| المؤلفون: | Telles GD; Laboratory of Neuromuscular Adaptations to Strength Training, School of Physical Education and Sport, University of São Paulo (USP), São Paulo, Brazil., Conceição MS; Department of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Campinas, Campinas, Brazil., Vechin FC; Laboratory of Neuromuscular Adaptations to Strength Training, School of Physical Education and Sport, University of São Paulo (USP), São Paulo, Brazil., Libardi CA; MUSCULAB-Laboratory of Neuromuscular Adaptations to Resistance Training, Department of Physical Education, Federal University of São Carlos (UFSCar), São Carlos, Brazil., Mori MADS; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, Brazil.; Obesity and Comorbidities Research Center (OCRC), University of Campinas, Campinas, Brazil.; Experimental Medicine Research Cluster (EMRC), Campinas, Brazil., Derchain S; Department of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Campinas, Campinas, Brazil., Ugrinowitsch C; Laboratory of Neuromuscular Adaptations to Strength Training, School of Physical Education and Sport, University of São Paulo (USP), São Paulo, Brazil. |
| المصدر: | Frontiers in physiology [Front Physiol] 2022 Jun 16; Vol. 13, pp. 800094. Date of Electronic Publication: 2022 Jun 16 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101549006 Publication Model: eCollection Cited Medium: Print ISSN: 1664-042X (Print) Linking ISSN: 1664042X NLM ISO Abbreviation: Front Physiol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Research Foundation |
| مستخلص: | Losses in skeletal muscle mass, strength, and metabolic function are harmful in the pathophysiology of serious diseases, including breast cancer. Physical exercise training is an effective non-pharmacological strategy to improve health and quality of life in patients with breast cancer, mainly through positive effects on skeletal muscle mass, strength, and metabolic function. Emerging evidence has also highlighted the potential of exercise-induced crosstalk between skeletal muscle and cancer cells as one of the mechanisms controlling breast cancer progression. This intercellular communication seems to be mediated by a group of skeletal muscle molecules released in the bloodstream known as myokines. Among the myokines, exercise-induced circulating microRNAs (c-miRNAs) are deemed to mediate the antitumoral effects produced by exercise training through the control of key cellular processes, such as proliferation, metabolism, and signal transduction. However, there are still many open questions regarding the molecular basis of the exercise-induced effects on c-miRNA on human breast cancer cells. Here, we present evidence regarding the effect of exercise training on c-miRNA expression in breast cancer, along with the current gaps in the literature and future perspectives. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Telles, Conceição, Vechin, Libardi, Mori, Derchain and Ugrinowitsch.) |
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| فهرسة مساهمة: | Keywords: breast cancer; crosstalk; disease; epigenetics; intercellular communication; miRNA; skeletal muscle; tumor |
| تواريخ الأحداث: | Date Created: 20220705 Latest Revision: 20220716 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9244175 |
| DOI: | 10.3389/fphys.2022.800094 |
| PMID: | 35784874 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-042X |
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| DOI: | 10.3389/fphys.2022.800094 |