دورية أكاديمية
أعرض في EDS

Increased neutrophil count Is associated with the development of chronic kidney disease in patients with diabetes.

التفاصيل البيبلوغرافية
العنوان: Increased neutrophil count Is associated with the development of chronic kidney disease in patients with diabetes.
المؤلفون: Zhang R; Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China., Chen J; MaQiao Community Health Service Center, Shanghai, China., Xiong Y; Gumei Community Health Service Center, Shanghai, China., Wang L; Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China., Huang X; Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China., Sun T; Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China., Zha B; Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China., Wu Y; Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China., Yan C; Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China., Zang S; Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China., Zhou Q; Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.; Key Laboratory of Disease Prevention and Control Technology, Hangzhou, China.; National Key Clinical Department of Kidney Disease, Hangzhou, China.; Institute of Nephrology, Zhejiang University, Hangzhou, China.; The Third Grade Laboratory under the National State, Administration of Traditional Chinese Medicine, Hangzhou, China., Huang Z; Department of Genetics and Developmental Science, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China., Liu J; Department of Endocrinology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
المصدر: Journal of diabetes [J Diabetes] 2022 Jul; Vol. 14 (7), pp. 442-454. Date of Electronic Publication: 2022 Jul 04.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Blackwell Publishing Asia Country of Publication: Australia NLM ID: 101504326 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1753-0407 (Electronic) Linking ISSN: 17530407 NLM ISO Abbreviation: J Diabetes Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Richmond, Vic. : Blackwell Publishing Asia, 2009-
مواضيع طبية MeSH: Diabetes Mellitus* , Renal Insufficiency, Chronic*/complications , Renal Insufficiency, Chronic*/epidemiology, Cohort Studies ; Cross-Sectional Studies ; Disease Progression ; Humans ; Neutrophils ; Proportional Hazards Models ; Risk Factors
مستخلص: Background: This study aims to investigate the potential association of peripheral inflammatory blood cell parameters with the incidence and progression of chronic kidney disease (CKD) in patients with diabetes.
Methods: The cross-sectional study included 1192 subjects with diabetes derived from one center. The cohort study included 2060 subjects with diabetes derived from another two centers followed up for 4 years. Logistic regression and Cox proportional hazards models were used to evaluate the association of peripheral inflammatory blood cell with CKD.
Results: In the cross-sectional study, neutrophil count performed best as an independent risk factor for CKD (odds ratio 2.556 [95% confidence interval 1.111, 5.879]) even after 1:1 case-control matching for age, gender, history of high blood pressure and duration of diabetes. Spline regression revealed a significant linear association of CKD incidence with continuous neutrophil count in excess of 3.6 × 10 9 /L. In the cohort study, subjects were grouped based on tertile of neutrophil count and neutrophil-to-lymphocyte ratio. Cox regression analysis results showed that only neutrophil count was independently associated with CKD progression (the highest group vs. the lowest group, hazard ratio 2.293 [95% confidence interval 1.260, 4.171]) after fully adjusting for potential confounders. The cumulative incidence of CKD progression in patients with diabetes gradually increased with increasing neutrophil count (53 (7.7%) subjects in the lowest group vs. 60 (8.2%) in the middle group vs. 78 (12.2%) in the highest group).
Conclusions: This study suggested that neutrophil count is an independent risk factor for progression of CKD in patients with diabetes.
(© 2022 The Authors. Journal of Diabetes published by Ruijin Hospital, Shanghai JiaoTong University School of Medicine and John Wiley & Sons Australia, Ltd.)
References: Nat Med. 2011 Nov 07;17(11):1381-90. (PMID: 22064428)
Nat Rev Immunol. 2006 Jul;6(7):541-50. (PMID: 16799473)
Diabetes Care. 2005 Jul;28(7):1710-7. (PMID: 15983324)
Nat Rev Nephrol. 2016 Jan;12(1):13-26. (PMID: 26568190)
Kidney Int Rep. 2019 Aug 20;4(10):1362-1365. (PMID: 31701958)
Nephron. 2019;143(1):12-16. (PMID: 30273931)
Prim Care. 2020 Dec;47(4):645-659. (PMID: 33121634)
Am J Physiol Renal Physiol. 2017 Apr 1;312(4):F716-F731. (PMID: 27558558)
Biosci Rep. 2018 Jun 27;38(3):. (PMID: 29581246)
Diabetes Res Clin Pract. 2012 Jul;97(1):71-6. (PMID: 22402306)
J Clin Invest. 1950 May;29(5):496-507. (PMID: 15415454)
Clin Endocrinol (Oxf). 2015 Feb;82(2):229-33. (PMID: 25088518)
World J Diabetes. 2014 Aug 15;5(4):431-43. (PMID: 25126391)
Physiol Rep. 2019 Dec;7(24):e14333. (PMID: 31876119)
Expert Opin Investig Drugs. 2016 Sep;25(9):1045-58. (PMID: 27268955)
Clin J Am Soc Nephrol. 2009 Feb;4(2):337-44. (PMID: 19176795)
Lancet. 1999 May 15;353(9165):1649-52. (PMID: 10335783)
J Diabetes. 2022 Jul;14(7):442-454. (PMID: 35789114)
Diabetes. 2002 Feb;51(2):455-61. (PMID: 11812755)
Kidney Int. 2014 Mar;85(3):487-91. (PMID: 24336028)
Diabetes Metab Syndr. 2019 Jul - Aug;13(4):2365-2373. (PMID: 31405645)
Biomark Insights. 2016 Feb 16;11:31-40. (PMID: 26917947)
Nat Rev Immunol. 2019 Dec;19(12):734-746. (PMID: 31501536)
Diabetes. 2020 Jul;69(7):1401-1410. (PMID: 32332157)
Contrib Nephrol. 2018;192:103-109. (PMID: 29393137)
Int Urol Nephrol. 2017 May;49(5):837-844. (PMID: 28035619)
Contrib Nephrol. 2019;198:33-39. (PMID: 30991405)
JAMA. 1992 Mar 4;267(9):1253-6. (PMID: 1538564)
Nat Med. 2012 Sep;18(9):1407-12. (PMID: 22863787)
Pharmacol Rev. 2010 Dec;62(4):726-59. (PMID: 21079042)
Diabetes Care. 2022 Jan 1;45(Suppl 1):S185-S194. (PMID: 34964887)
Am J Kidney Dis. 2017 Aug;70(2):191-198. (PMID: 28196649)
Int J Biol Sci. 2018 Jul 27;14(10):1343-1360. (PMID: 30123081)
Cell Metab. 2013 Apr 2;17(4):534-48. (PMID: 23562077)
معلومات مُعتمدة: 201940295 Health Profession Clinical Research Funds of Shanghai Municipal Health Commission; ZK2019B15 Medical Key Faculty Foundation of Shanghai; 2020MW38 Minhang District Health Committee Project; 2019MHZ066 Natural Science Research Funds of Minhang District, Shanghai; 2018WYZD04 Scientific Research Project funded by Shanghai Fifth People's Hospital, Fudan University
فهرسة مساهمة: Keywords: chronic kidney disease; diabetes; inflammation; neutrophils; 中性粒细胞; 慢性肾脏疾病; 炎症; 糖尿病
Local Abstract: [Publisher, Chinese] 背景: 本研究旨在探讨糖尿病人中外周血炎性细胞参数与慢性肾脏疾病(CKD)的发生和发展之间的潜在相关性。 方法: 以1192名来自同一研究中心的受试者作为横断面研究。来自另外两个中心的2060名受试者随访4年，进入队列研究。采用Logistic回归和COX比例风险模型评价外周血炎性细胞与CKD的相关性。 结果: 在横断面研究中，即使在年龄、性别、高血压病史和糖尿病病程进行1:1病例对照匹配后，中性粒细胞计数仍然是CKD的最相关的独立危险因素(OR 2.556[95%CI 1.111，5.879])。样条回归显示CKD发病率与中性粒细胞计数持续超过3.6×10 9 /L呈显著线性相关。在队列研究中，受试者根据中性粒细胞计数和中性粒细胞/淋巴细胞比率的三分位进行分组。COX回归分析结果显示，在完全校正潜在混杂因素后，只有中性粒细胞计数与CKD进展独立相关(最高组vs.最低组，HR 2.293[95%CI 1.260，4.171])。随着中性粒细胞计数的增加，糖尿病患者CKD进展的累积发生率逐渐增加，最低组53例(7.7%)，中间组60例(8.2%)，最高组78例(12.2%)。 结论: 本研究提示中性粒细胞计数是糖尿病患者CKD进展的独立危险因素。.
تواريخ الأحداث: Date Created: 20220705 Date Completed: 20220726 Latest Revision: 20220727
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9310049
DOI: 10.1111/1753-0407.13292
PMID: 35789114
قاعدة البيانات: MEDLINE
الوصف
تدمد:1753-0407
DOI:10.1111/1753-0407.13292