دورية أكاديمية
Sex-Based Differences in Human Neutrophil Chemorepulsion.
| العنوان: | Sex-Based Differences in Human Neutrophil Chemorepulsion. |
|---|---|
| المؤلفون: | Consalvo KM; Department of Biology, Texas A&M University, College Station, TX., Kirolos SA; Department of Biology, Texas A&M University, College Station, TX., Sestak CE; Department of Biology, Texas A&M University, College Station, TX., Gomer RH; Department of Biology, Texas A&M University, College Station, TX rgomer@tamu.edu. |
| المصدر: | Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2022 Jul 15; Vol. 209 (2), pp. 354-367. Date of Electronic Publication: 2022 Jul 06. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association of Immunologists Country of Publication: United States NLM ID: 2985117R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Bethesda, MD : American Association of Immunologists Original Publication: Baltimore : Williams & Wilkins, c1950- |
| مواضيع طبية MeSH: | Dictyostelium*/metabolism , Neutrophils*, Actins/metabolism ; Chemotaxis ; Female ; Humans ; Male ; Sex Characteristics |
| مستخلص: | A considerable amount is known about how eukaryotic cells move toward an attractant, and the mechanisms are conserved from Dictyostelium discoideum to human neutrophils. Relatively little is known about chemorepulsion, where cells move away from a repellent signal. We previously identified pathways mediating chemorepulsion in Dictyostelium , and here we show that these pathways, including Ras, Rac, protein kinase C, PTEN, and ERK1 and 2, are required for human neutrophil chemorepulsion, and, as with Dictyostelium chemorepulsion, PI3K and phospholipase C are not necessary, suggesting that eukaryotic chemorepulsion mechanisms are conserved. Surprisingly, there were differences between male and female neutrophils. Inhibition of Rho-associated kinases or Cdc42 caused male neutrophils to be more repelled by a chemorepellent and female neutrophils to be attracted to the chemorepellent. In the presence of a chemorepellent, compared with male neutrophils, female neutrophils showed a reduced percentage of repelled neutrophils, greater persistence of movement, more adhesion, less accumulation of PI(3,4,5)P (Copyright © 2022 by The American Association of Immunologists, Inc.) |
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| معلومات مُعتمدة: | R01 GM118355 United States GM NIGMS NIH HHS; R35 GM139486 United States GM NIGMS NIH HHS |
| المشرفين على المادة: | 0 (Actins) |
| تواريخ الأحداث: | Date Created: 20220706 Date Completed: 20220714 Latest Revision: 20230716 |
| رمز التحديث: | 20230716 |
| مُعرف محوري في PubMed: | PMC9283293 |
| DOI: | 10.4049/jimmunol.2101103 |
| PMID: | 35793910 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1550-6606 |
|---|---|
| DOI: | 10.4049/jimmunol.2101103 |