دورية أكاديمية
أعرض في EDS

Sacroiliitis at diagnosis as a protective predictor against disease flare after stopping medication: outcomes of a Southeast Asian enthesitis-related arthritis (ERA) longitudinal cohort.

التفاصيل البيبلوغرافية
العنوان: Sacroiliitis at diagnosis as a protective predictor against disease flare after stopping medication: outcomes of a Southeast Asian enthesitis-related arthritis (ERA) longitudinal cohort.
المؤلفون: Teh KL; Rheumatology and Immunology Service, Department of Paediatric Subspecialties, KK Women's and Children's Hospital, Singapore, Singapore., Das L; Rheumatology and Immunology Service, Department of Paediatric Subspecialties, KK Women's and Children's Hospital, Singapore, Singapore., Book YX; Rheumatology and Immunology Service, Department of Paediatric Subspecialties, KK Women's and Children's Hospital, Singapore, Singapore., Hoh SF; Division of Nursing, KK Women's and Children's Hospital, Singapore, Singapore., Gao X; Division of Nursing, KK Women's and Children's Hospital, Singapore, Singapore., Arkachaisri T; Rheumatology and Immunology Service, Department of Paediatric Subspecialties, KK Women's and Children's Hospital, Singapore, Singapore. thaschawee.arkachaisri@singhealth.com.sg.; Duke-NUS Medical School, Singapore, Singapore. thaschawee.arkachaisri@singhealth.com.sg.
المصدر: Clinical rheumatology [Clin Rheumatol] 2022 Oct; Vol. 41 (10), pp. 3027-3034. Date of Electronic Publication: 2022 Jul 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 8211469 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1434-9949 (Electronic) Linking ISSN: 07703198 NLM ISO Abbreviation: Clin Rheumatol Subsets: MEDLINE
أسماء مطبوعة: Publication: <2008->: Heidelberg : Springer
Original Publication: Brussels : Acta Medica Belgica, [1982-
مواضيع طبية MeSH: Arthritis, Juvenile*/drug therapy , Biological Products*/therapeutic use , Sacroiliitis*/drug therapy, Child ; HLA-B27 Antigen ; Humans ; Male ; Symptom Flare Up
مستخلص: Objectives: To assess short- and long-term outcomes of ERA in a large monocentric cohort in Singapore.
Methods: Children diagnosed with ERA according to ILAR criteria from 2002 to 2021 were recruited. Nonparametric statistics were used to describe the data. Outcomes were defined according to modified Wallace criteria, and probabilities and predictors were determined using Kaplan-Meier survival and logistic regression analyses.
Results: One hundred fifty-one ERA patients (male 86%; Chinese 81%) were included. The median age at onset was 11.9 years (IQR: 9.4-13.9), and disease duration was 5.3 years (IQR: 2.9-8.4). At diagnosis, 39% of the patients had sacroiliitis. HLA-B27 was positive in 83%, and biologics were used in 72% of the patients. Clinical inactive disease (CID) was achieved in 92% of the patients, of which 27% achieved within 6 months. Sacroiliitis at diagnosis is an unfavorable predictor of early CID at 6 months. Medication was discontinued in one-third of the patients. Favorable predictor of medication withdrawal includes male gender, while unfavorable predictors include positive HLA-B27 and ANA. Two-thirds of the patients with CID had at least one disease flare. Sacroiliitis at diagnosis is a protective predictor of flare after stopping medication.
Conclusion: Despite a high proportion of ERA patients achieving CID, only one-third could stop medication with high rates of disease flare. Unfavorable predictors include older age at onset, HLA-B27, and ANA positivity. While sacroiliitis at diagnosis is a negative predictor of CID at 6 months, it is associated with less disease flare after discontinuing medication.
(© 2022. The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR).)
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فهرسة مساهمة: Keywords: Enthesitis-related arthritis; Juvenile idiopathic arthritis; Outcomes; Predictors; Singapore
المشرفين على المادة: 0 (Biological Products)
0 (HLA-B27 Antigen)
تواريخ الأحداث: Date Created: 20220706 Date Completed: 20220922 Latest Revision: 20220922
رمز التحديث: 20240628
DOI: 10.1007/s10067-022-06275-z
PMID: 35794290
قاعدة البيانات: MEDLINE
الوصف
تدمد:1434-9949
DOI:10.1007/s10067-022-06275-z