دورية أكاديمية
Modulation of matrix metalloproteases by ciliary neurotrophic factor in human placental development.
العنوان: | Modulation of matrix metalloproteases by ciliary neurotrophic factor in human placental development. |
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المؤلفون: | Tossetta G; Department of Experimental and Clinical Medicine, Università Politecnica Delle Marche, 60126, Ancona, Italy.; Clinica Di Ostetricia E Ginecologia, Azienda Ospedaliero Universitaria Ospedali Riuniti Di Ancona, 60123, Ancona, Italy., Fantone S; Department of Experimental and Clinical Medicine, Università Politecnica Delle Marche, 60126, Ancona, Italy., Busilacchi EM; Department of Clinical and Molecular Sciences, Università Politecnica Delle Marche, Ancona, Italy.; Hematology Unit, AUO Ospedali Riuniti Di Ancona, 60123, Ancona, Italy., Di Simone N; Department of Biomedical Science, Humanitas University, Via Rita Levi Montalcini 4, 20090, Pieve Emanuele, Milan, Italy.; Humanitas Clinical and Research Center-IRCCS, Via Manzoni56, 20089, Rozzano, Italy., Giannubilo SR; Clinica Di Ostetricia E Ginecologia, Azienda Ospedaliero Universitaria Ospedali Riuniti Di Ancona, 60123, Ancona, Italy.; Department of Clinical Sciences, Università Politecnica Delle Marche, Salesi Hospital, 60123, Ancona, Italy., Scambia G; U.O.C. Di Ostetricia E Patologia Ostetrica, Dipartimento Di Scienze Della Salute Della Donna, Fondazione Policlinico Universitario A. Gemelli IRCCS, del Bambino E Di Sanità Pubblica, 00168, Rome, Italy.; Istituto Di Clinica Ostetrica E Ginecologica, Università Cattolica del Sacro Cuore, 00168, Rome, Italy., Giordano A; Department of Experimental and Clinical Medicine, Università Politecnica Delle Marche, 60126, Ancona, Italy. a.giordano@staff.univpm.it., Marzioni D; Department of Experimental and Clinical Medicine, Università Politecnica Delle Marche, 60126, Ancona, Italy. d.marzioni@staff.univpm.it. |
المصدر: | Cell and tissue research [Cell Tissue Res] 2022 Oct; Vol. 390 (1), pp. 113-129. Date of Electronic Publication: 2022 Jul 07. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417625 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0878 (Electronic) Linking ISSN: 0302766X NLM ISO Abbreviation: Cell Tissue Res Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Berlin, New York, Springer-Verlag. |
مواضيع طبية MeSH: | Ciliary Neurotrophic Factor*/metabolism , Ciliary Neurotrophic Factor*/pharmacology , Curcumin*, Ciliary Neurotrophic Factor Receptor alpha Subunit/metabolism ; Cytokines/metabolism ; Female ; Humans ; Matrix Metalloproteinase 1 ; Matrix Metalloproteinase 9 ; Placenta/metabolism ; Placentation ; Pregnancy ; Receptor, Ciliary Neurotrophic Factor/metabolism |
مستخلص: | Ciliary neurotrophic factor (CNTF) is a pleiotropic cytokine that signals through a receptor complex containing a specific subunit, CNTF receptor α (CNTFRα). The two molecules are constitutively expressed in key structures for human placental growth and differentiation. The possible role of CNTF in enhancing cell proliferation and/or invasion during placental development and remodelling was investigated using HTR-8/SVneo and BeWo cells, taken respectively as cytotrophoblast and syncytiotrophoblast models. In both cell lines, treatment with human recombinant (hr) CNTF activated JAK2/STAT3 signalling and inhibited the ERK pathway. Interestingly, in HTR-8/SVneo cells, 50 ng hrCNTF induced significant downregulation of matrix metalloprotease (MMP)-1 and significant upregulation of MMP-9. Moreover, pharmacological inhibition of JAK2/STAT3 signalling by AG490 and curcumin resulted in MMP-9 downregulation; it activated the ERK signalling pathway and upregulated MMP-1 expression. Collectively, these data suggest a role for CNTF signalling in extravillous cytotrophoblast invasion through the modulation of specific MMPs. (© 2022. The Author(s).) |
التعليقات: | Erratum in: Cell Tissue Res. 2023 Jun;392(3):827. (PMID: 37086301) |
References: | Blood. 2016 Oct 27;128(17):2153-2164. (PMID: 27589872) Sci Rep. 2016 May 13;6:25870. (PMID: 27174608) Sci Rep. 2016 Jan 27;6:19916. (PMID: 26814137) Cardiovasc Res. 2006 Feb 15;69(3):562-73. (PMID: 16405877) Reprod Sci. 2019 Jul;26(7):928-938. (PMID: 30373477) J Alzheimers Dis. 2013;37(3):587-92. (PMID: 23948898) Dose Response. 2015 Nov 12;13(4):1559325815611902. (PMID: 26740808) J Biol Chem. 2014 Jun 27;289(26):18442-50. (PMID: 24802752) Acta Med Okayama. 2010 Apr;64(2):129-36. (PMID: 20424668) J Clin Pathol. 2008 Dec;61(12):1296-302. (PMID: 18755720) Cytokine. 2009 Apr;46(1):65-71. (PMID: 19272793) Exp Cell Res. 1993 Jun;206(2):204-11. (PMID: 7684692) PLoS One. 2012;7(1):e29855. (PMID: 22253805) Clin Exp Metastasis. 2002;19(8):709-16. (PMID: 12553377) Biochem J. 2003 Aug 15;374(Pt 1):1-20. (PMID: 12773095) J Cell Biol. 1991 Apr;113(2):437-49. (PMID: 1849141) Hum Reprod Update. 2007 Mar-Apr;13(2):121-41. (PMID: 17068222) Front Endocrinol (Lausanne). 2019 Nov 12;10:768. (PMID: 31781039) Oncotarget. 2017 Apr 25;8(35):58642-58653. (PMID: 28938585) Gene. 1991 Jun 30;102(2):271-6. (PMID: 1840538) Nature. 1970 Aug 15;227(5259):680-5. (PMID: 5432063) J Cell Physiol. 2019 May;234(5):6091-6098. (PMID: 30426491) Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4017-26. (PMID: 27494343) J Cell Biol. 1989 Aug;109(2):891-902. (PMID: 2474556) Prog Mol Biol Transl Sci. 2017;148:87-165. (PMID: 28662830) Placenta. 2000 Mar-Apr;21 Suppl A:S113-9. (PMID: 10831135) Eur J Histochem. 2020 Oct 19;64(4):. (PMID: 33131268) Expert Rev Clin Immunol. 2011 Sep;7(5):603-9. (PMID: 21895473) Amino Acids. 2011 Jul;41(2):271-90. (PMID: 20640864) Histochem Cell Biol. 2018 Oct;150(4):361-370. (PMID: 30046889) Artif Cells Nanomed Biotechnol. 2018 Dec;46(8):1694-1707. (PMID: 29065723) J Tissue Eng Regen Med. 2014 Dec;8(12):963-8. (PMID: 23147834) Proteomics. 2017 May;17(10):e1700037. (PMID: 28317260) Turk Patoloji Derg. 2019;35(1):1-8. (PMID: 30596394) Hum Reprod. 2007 Jul;22(7):1801-9. (PMID: 17525067) Acta Histochem. 2008;110(5):371-9. (PMID: 18275985) Gynecol Oncol. 1999 Nov;75(2):248-53. (PMID: 10525381) J Obstet Gynaecol. 2013 May;33(4):359-63. (PMID: 23654315) Oncol Rep. 2017 Jul;38(1):418-426. (PMID: 28586045) Diabetes. 2009 Apr;58(4):829-39. (PMID: 19136654) Int J Mol Sci. 2017 Jul 20;18(7):. (PMID: 28726716) Biochem Biophys Res Commun. 2013 Mar 1;432(1):116-22. (PMID: 23376068) J Cell Biochem. 2018 Aug;119(8):6657-6664. (PMID: 29665148) J Neurochem. 2009 Jan;108(1):246-59. (PMID: 19046323) Biomed Res Int. 2013;2013:243649. (PMID: 23586024) Best Pract Res Clin Endocrinol Metab. 2015 Oct;29(5):787-97. (PMID: 26522462) Gene. 1995 Sep 11;162(2):285-9. (PMID: 7557445) Histochem Cell Biol. 2020 Sep;154(3):339-346. (PMID: 32529396) Mol Hum Reprod. 1999 Nov;5(11):1055-8. (PMID: 10541568) J Histochem Cytochem. 1995 Jun;43(6):579-89. (PMID: 7539466) Placenta. 2015 Jan;36(1):59-68. (PMID: 25465704) Ginekol Pol. 2012 Jun;83(6):439-45. (PMID: 22880464) |
معلومات مُعتمدة: | Starting Grant 2018 (SG-2018-12367994) Italian Ministry of Health; RSA 2018 - 2020 Università Politecnica delle Marche |
فهرسة مساهمة: | Keywords: CNTF; MMP; Placenta; pSTAT3, pERK |
المشرفين على المادة: | 0 (Ciliary Neurotrophic Factor) 0 (Ciliary Neurotrophic Factor Receptor alpha Subunit) 0 (Cytokines) 0 (Receptor, Ciliary Neurotrophic Factor) EC 3.4.24.35 (Matrix Metalloproteinase 9) EC 3.4.24.7 (Matrix Metalloproteinase 1) IT942ZTH98 (Curcumin) |
تواريخ الأحداث: | Date Created: 20220706 Date Completed: 20221004 Latest Revision: 20230424 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC9525382 |
DOI: | 10.1007/s00441-022-03658-1 |
PMID: | 35794391 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1432-0878 |
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DOI: | 10.1007/s00441-022-03658-1 |