دورية أكاديمية
Effects of Lysophosphatidylcholine on Jejuna Morphology and Its Potential Mechanism.
| العنوان: | Effects of Lysophosphatidylcholine on Jejuna Morphology and Its Potential Mechanism. |
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| المؤلفون: | Li X; College of Animal Science, Anhui Science and Technology University, Huainan, China., Abdel-Moneim AE; Department of Biological Applications, Nuclear Research Center, Egyptian Atomic Energy Authority, Abu-Zaabal, Egypt., Mesalam NM; Department of Biological Applications, Nuclear Research Center, Egyptian Atomic Energy Authority, Abu-Zaabal, Egypt., Yang B; College of Animal Science, Anhui Science and Technology University, Huainan, China. |
| المصدر: | Frontiers in veterinary science [Front Vet Sci] 2022 Jun 20; Vol. 9, pp. 911496. Date of Electronic Publication: 2022 Jun 20 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101666658 Publication Model: eCollection Cited Medium: Print ISSN: 2297-1769 (Print) Linking ISSN: 22971769 NLM ISO Abbreviation: Front Vet Sci Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Media S.A., [2014]- |
| مستخلص: | Lysophosphatidylcholine (LPC) plays a vital role in promoting jejuna morphology in broilers. However, the potential mechanism behind LPC improving the chicken jejuna morphology is unclear. Therefore, the present study was designed to reveal the important genes associated with LPC regulation in birds' jejuna. Thus, GSE94622, the gene expression microarray, was obtained from Gene Expression Omnibus (GEO). GSE94622 consists of 15 broiler jejuna samples from two LPC-treated (LPC500 and LPC1000) and the control groups. Totally 98 to 217 DEGs were identified by comparing LPC500 vs. control, LPC1000 vs. control, and LPC1000 vs. LPC500. Gene ontology (GO) analysis suggested that those DEGs were mainly involved in the one-carbon metabolic process, carbon dioxide transport, endodermal cell differentiation, the positive regulation of dipeptide transmembrane transport, cellular pH reduction, and synaptic transmission. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis indicated the DEGs were enriched in NOD-like receptor (NLR), RIG-I-like receptor (RILR), Toll-like receptor (TLR), and necroptosis signaling pathway. Moreover, many genes, such as RSAD2, OASL, EPSTI1, CMPK2, IFIH1, IFIT5, USP18, MX1, and STAT1 might be involved in promoting the jejuna morphology of broilers. In conclusion, this study enhances our understanding of LPC regulation in jejuna morphology. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Li, Abdel-Moneim, Mesalam and Yang.) |
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| فهرسة مساهمة: | Keywords: broiler; gene; jejuna; lysophosphatidylcholine; signaling pathway |
| تواريخ الأحداث: | Date Created: 20220707 Latest Revision: 20220716 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC9252431 |
| DOI: | 10.3389/fvets.2022.911496 |
| PMID: | 35795789 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2297-1769 |
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| DOI: | 10.3389/fvets.2022.911496 |