دورية أكاديمية
أعرض في EDS

Amazonian Guarana- and Açai-Conjugated Extracts Improve Scratched Fibroblast Healing and Eisenia fetida Surgical Tail Amputation by Modulating Oxidative Metabolism.

التفاصيل البيبلوغرافية
العنوان: Amazonian Guarana- and Açai-Conjugated Extracts Improve Scratched Fibroblast Healing and Eisenia fetida Surgical Tail Amputation by Modulating Oxidative Metabolism.
المؤلفون: Felin FD; Mestrado Profissional em Ciências da Saúde, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil 97105-9000., Maia-Ribeiro EA; Universidade do Estado do Amazonas-Fundação Universidade Aberta da Terceira Idade (FUNATI), Manaus, AM, Brazil 69029-000., Felin CD; Pontíficia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil 90619-900., Bonotto NAC; Programa de Pós-Graduação em Gerontologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil 97105-9000., Turra BO; Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil 97105-9000., Roggia I; Programa de Pós-Graduação em Gerontologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil 97105-9000., Azzolin VF; Programa de Pós-Graduação em Gerontologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil 97105-9000., Teixeira CF; Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil 97105-9000., Mastella MH; Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil 97105-9000., de Freitas CR; Laboratório de Biogenômica, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil 97105-9000., Greijanim J; Laboratório de Biogenômica, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil 97105-9000., Santos D; Departamento de Química, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil 97105-9000., Flores EMM; Laboratório de Biogenômica, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil 97105-9000., Barbisan F; Programa de Pós-Graduação em Gerontologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil 97105-9000.; Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil 97105-9000.; Departamento de Patologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil 97105-9000., Cruz IBM; Programa de Pós-Graduação em Gerontologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil 97105-9000.; Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil 97105-9000., Ribeiro TA; Mestrado Profissional em Ciências da Saúde, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil 97105-9000.
المصدر: Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2022 Jun 26; Vol. 2022, pp. 3094362. Date of Electronic Publication: 2022 Jun 26 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 101479826 Publication Model: eCollection Cited Medium: Internet ISSN: 1942-0994 (Electronic) Linking ISSN: 19420994 NLM ISO Abbreviation: Oxid Med Cell Longev Subsets: MEDLINE
أسماء مطبوعة: Publication: 2011- : New York : Hindawi Pub. Corp.
Original Publication: 2008-2010: Austin, TX : Landes Bioscience
مواضيع طبية MeSH: Oligochaeta* , Paullinia*, Amputation, Surgical ; Animals ; Antioxidants/pharmacology ; Fibroblasts ; Oxidative Stress ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Wound Healing
مستخلص: Background: Previous studies have suggested that guarana ( Paullinia cupana ) and açai ( Euterpe oleracea ) have antioxidant, anti-inflammatory, and proliferative properties, indicating their potential therapeutic action in wound healing. We produced a conjugated guarana-açai (GA) extract and tested its healing action on earthworms ( Eisenia fetida ) subjected to tail amputation by surgical incision.
Methods: Extract from roasted guarana seeds and fresh açai seed berries was produced. The antioxidant and genoprotective capacity of GA extract was tested. The concentration with the most remarkable healing potential was used in subsequent tests. The last three posterior segments of the clitellate earthworm tail reared under standardized conditions were surgically amputated. Next, topical PBS or GA extract was applied to the surgical wound. The rate of cell migration and tissue regeneration at the local wound site was histologically evaluated after the procedure. Expression of the SOX4 gene that acts in epithelial-to-mesenchymal transition was determined by RT-qPCR.
Results: Sixteen bioactive molecules, including some previously described substances, were identified. All tested concentrations exhibited antioxidant and genoprotective effects. The GA extract accelerated the healing processes as observed through macroscopic and histological analyses and increased expression of SOX4.
Conclusion: The GA extract has a potential role in the healing of surgically induced wounds.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have influenced the work reported in this paper.
(Copyright © 2022 Fellipe D. Felin et al.)
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المشرفين على المادة: 0 (Antioxidants)
0 (Plant Extracts)
تواريخ الأحداث: Date Created: 20220707 Date Completed: 20220708 Latest Revision: 20221207
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9251138
DOI: 10.1155/2022/3094362
PMID: 35795860
قاعدة البيانات: MEDLINE
الوصف
تدمد:1942-0994
DOI:10.1155/2022/3094362