دورية أكاديمية
أعرض في EDS

Identification of potential biomarkers and survival analysis for oral squamous cell carcinoma: A transcriptomic study.

التفاصيل البيبلوغرافية
العنوان: Identification of potential biomarkers and survival analysis for oral squamous cell carcinoma: A transcriptomic study.
المؤلفون: de Paula Souza DPS; Departament of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Brazil., Dos Reis Pereira Queiroz L; Departament of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Brazil., de Souza MG; Departament of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Brazil., de Jesus SF; Departament of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Brazil., Gomes ESB; Departament of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Brazil., Vitorino RT; Departament of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Brazil., Santos SHS; Institute of Agricultural Sciences, Universidade Federal de Minas Gerais, Montes Claros, Brazil., Farias LC; Departament of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Brazil., de Paula AMB; Departament of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Brazil., D'Angelo MFSV; Department of Computer Science, Universidade Estadual de Montes Claros, Montes Claros, Brazil., de Carvalho Fraga CA; Universidade Federal de Alagoas, Arapiraca, Brazil., Guimarães ALS; Departament of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, Brazil.
المصدر: Oral diseases [Oral Dis] 2023 Oct; Vol. 29 (7), pp. 2658-2666. Date of Electronic Publication: 2022 Jul 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Munksgaard Country of Publication: Denmark NLM ID: 9508565 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1601-0825 (Electronic) Linking ISSN: 1354523X NLM ISO Abbreviation: Oral Dis
أسماء مطبوعة: Publication: 2001- : Copenhagen, Denmark : Munksgaard
Original Publication: Houndmills, Basingstoke, Hampshire, UK : Stockton Press, c1995-
مواضيع طبية MeSH: Carcinoma, Squamous Cell*/pathology , Mouth Neoplasms*/metabolism , Head and Neck Neoplasms*/genetics, Humans ; Squamous Cell Carcinoma of Head and Neck/genetics ; Transcriptome ; Gene Expression Regulation, Neoplastic ; Survival Analysis ; Biomarkers, Tumor/genetics ; Prognosis
مستخلص: Objective: Oral squamous cell carcinoma (OSCC) is one of the most common neoplasms worldwide. The current study aimed to identify potential biomarkers associated with OSCC survival.
Materials and Methods: Differentially expressed genes (DEGs) in atypical OSCC cases were identified using two public datasets: The Cancer Genome Atlas and the Gene Expression Omnibus database. Receiver operating characteristic (ROC) analysis was performed to identify the cutoff, and the candidate DEGs related to survival. Kaplan-Meier and Cox regression analysis using the categorized genes were employed to identify genes that impact the overall survival in OSCC.
Results: A total of 263 OSCC samples and 105 healthy tissues were used to identify 295 upregulated and 131 downregulated genes expressed only in non-smokers. ROC analyses identified 25 candidate genes associated with death. Survival analyses demonstrated that the following DEGs, namely CSTA, FGFR2, MMP19, OLR1, PCSK1, RAMP2, and CGB5, are potential OSCC prognostic factors.
Conclusion: We found that CSTA, FGFR2, MMP19, OLR1, PCSK1, RAMP2, and CGB5 are associated with a low survival rate in OSCC. However, further studies are needed to validate our findings and facilitate the development of these factors as potential biomarkers for OSCC survival.
(© 2022 Wiley Periodicals LLC.)
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معلومات مُعتمدة: Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de Minas Gerais
فهرسة مساهمة: Keywords: bioinformatics; biomarker; gene expression omnibus; oral squamous cell carcinoma; the cancer genome atlas; transcriptomic analysis
المشرفين على المادة: 0 (Biomarkers, Tumor)
تواريخ الأحداث: Date Created: 20220707 Date Completed: 20231002 Latest Revision: 20231002
رمز التحديث: 20231215
DOI: 10.1111/odi.14302
PMID: 35796645
قاعدة البيانات: MEDLINE
الوصف
تدمد:1601-0825
DOI:10.1111/odi.14302