دورية أكاديمية

Association between tamoxifen and tooth loss in women with breast cancer.

التفاصيل البيبلوغرافية
العنوان: Association between tamoxifen and tooth loss in women with breast cancer.
المؤلفون: de Araujo Sensever F; Franciscan University (UFN), Santa Maria, Brazil., Jardim LC; Franciscan University (UFN), Santa Maria, Brazil., Ferrazzo KL; Department of Pathology, Federal University of Santa Maria (UFSM), Santa Maria, Brazil., Skupien JA; Franciscan University (UFN), Santa Maria, Brazil., Antoniazzi RP; Department of Stomatology, Federal University of Santa Maria (UFSM), Roraima, 1000, Santa Maria, 97015-900, Brazil. raquelantoniazzi@hotmail.com.
المصدر: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2022 Oct; Vol. 30 (10), pp. 8193-8199. Date of Electronic Publication: 2022 Jul 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 9302957 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-7339 (Electronic) Linking ISSN: 09414355 NLM ISO Abbreviation: Support Care Cancer Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin : Springer International, c1993-
مواضيع طبية MeSH: Breast Neoplasms*/drug therapy , Dental Caries*/chemically induced , Dental Caries*/epidemiology , Tooth Loss*/chemically induced , Tooth Loss*/epidemiology, Aged ; Cross-Sectional Studies ; Female ; Humans ; Myeloma Proteins ; Prevalence ; Tamoxifen/adverse effects
مستخلص: Objectives: Investigate the effect of tamoxifen on the occurrence of tooth loss (TL) in breast cancer (BC) survivors.
Methods: A cross-sectional study was conducted with 140 BC survivors using tamoxifen therapy. Sociodemographic, medical, and dental data were evaluated. TL was determined using the M component of the Decayed, Missing and Filled Teeth (DMFT) index. Logistic regression models were run to determine associations between the independent variables and outcome (TL).
Results: Mean TL was 12.96 (SD 8.88). Only three participants had lost no teeth and 10.7% were completely edentulous. Participants who used tamoxifen for more than 1 year had a higher mean missing teeth (13.99 vs. 10.45; P = 0.030). After the adjustments, the occurrence of more than 12 missing teeth was 2.75-fold higher among women who used tamoxifen for more than 1 year (95% CI: 1.06-7.12). Moreover, age over 65 years, referral for treatment by the public healthcare system, less use of dental services, xerostomia, and a lower occurrence of dental caries remained associated with the loss of more than 12 teeth.
Conclusion: Longer use of tamoxifen was associated with greater tooth loss in breast cancer survivors.
Clinical Relevance: Based on estimates of the increase in cases of breast cancer, the prolonged use of tamoxifen for the treatment of this disease can exert an impact on oral health through the occurrence of tooth loss. These findings can contribute to the planning and implementation of oral health care and prevention strategies for such patients.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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فهرسة مساهمة: Keywords: Breast cancer; Dental caries; Oral health; Tamoxifen; Tooth extraction
المشرفين على المادة: 0 (Myeloma Proteins)
094ZI81Y45 (Tamoxifen)
تواريخ الأحداث: Date Created: 20220707 Date Completed: 20220928 Latest Revision: 20220928
رمز التحديث: 20231215
DOI: 10.1007/s00520-022-07271-4
PMID: 35796887
قاعدة البيانات: MEDLINE
الوصف
تدمد:1433-7339
DOI:10.1007/s00520-022-07271-4