دورية أكاديمية
Efficacy of 0.01% atropine for myopia control in a randomized, placebo-controlled trial depends on baseline electroretinal response.
| العنوان: | Efficacy of 0.01% atropine for myopia control in a randomized, placebo-controlled trial depends on baseline electroretinal response. |
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| المؤلفون: | Chan HHL; Laboratory of Experimental Optometry (Neuroscience), School of Optometry, The Hong Kong Polytechnic University, 11 Yuk Choi Road, Hung Hom, Kowloon, Hong Kong. henryhl.chan@polyu.edu.hk.; Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong. henryhl.chan@polyu.edu.hk.; Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Kowloon, Hong Kong. henryhl.chan@polyu.edu.hk.; Centre for Eye and Vision Research Limited, 17W Hong Kong Science Park, Shatin, Hong Kong. henryhl.chan@polyu.edu.hk.; University Research Facilities in Behavioral and Systems Neuroscience (UBSN), The Hong Kong Polytechnic University, Kowloon, Hong Kong. henryhl.chan@polyu.edu.hk., Choi KY; Laboratory of Experimental Optometry (Neuroscience), School of Optometry, The Hong Kong Polytechnic University, 11 Yuk Choi Road, Hung Hom, Kowloon, Hong Kong.; Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong., Ng ALK; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong., Choy BNK; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong., Chan JCH; Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong., Chan SSH; Laboratory of Experimental Optometry (Neuroscience), School of Optometry, The Hong Kong Polytechnic University, 11 Yuk Choi Road, Hung Hom, Kowloon, Hong Kong.; Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong., Li SZC; Laboratory of Experimental Optometry (Neuroscience), School of Optometry, The Hong Kong Polytechnic University, 11 Yuk Choi Road, Hung Hom, Kowloon, Hong Kong.; Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong., Yu WY; Laboratory of Experimental Optometry (Neuroscience), School of Optometry, The Hong Kong Polytechnic University, 11 Yuk Choi Road, Hung Hom, Kowloon, Hong Kong. |
| المصدر: | Scientific reports [Sci Rep] 2022 Jul 08; Vol. 12 (1), pp. 11588. Date of Electronic Publication: 2022 Jul 08. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
| مواضيع طبية MeSH: | Atropine* , Myopia*/drug therapy, Axial Length, Eye ; Child ; Disease Progression ; Humans ; Ophthalmic Solutions ; Refraction, Ocular ; Vision Tests |
| مستخلص: | This study aimed to evaluate the efficacy of 18-month 0.01% atropine in 61 myopic children (aged 7-10) and the relationship with central retinal response (by multifocal electroretinogram [mfERG]) in a double-masked randomized placebo-controlled clinical trial. Global-flash mfERG was measured at baseline, while cycloplegic spherical equivalent refraction (SER) and axial length (AL) were measured at baseline and at 6-month intervals. Annualized change in SER and AL were compared between atropine and control groups, and the relationships with baseline mfERG were evaluated. Changes in SER (-0.70 ± 0.39D vs. -0.66 ± 0.41D, p = 0.63) and AL (0.32 ± 0.16 mm vs. 0.30 ± 0.22 mm, p = 0.52) were similar in atropine and control groups. Interestingly, in the placebo group, mfERG amplitude was negatively correlated with axial elongation (R (© 2022. The Author(s).) |
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| المشرفين على المادة: | 0 (Ophthalmic Solutions) 7C0697DR9I (Atropine) |
| تواريخ الأحداث: | Date Created: 20220708 Date Completed: 20220712 Latest Revision: 20220915 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9270320 |
| DOI: | 10.1038/s41598-022-15686-6 |
| PMID: | 35804049 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2045-2322 |
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| DOI: | 10.1038/s41598-022-15686-6 |