دورية أكاديمية
أعرض في EDS

Catalytic Antibodies in Bipolar Disorder: Serum IgGs Hydrolyze Myelin Basic Protein.

التفاصيل البيبلوغرافية
العنوان: Catalytic Antibodies in Bipolar Disorder: Serum IgGs Hydrolyze Myelin Basic Protein.
المؤلفون: Kamaeva DA; Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634014 Tomsk, Russia., Smirnova LP; Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634014 Tomsk, Russia., Vasilieva SN; Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634014 Tomsk, Russia., Kazantseva DV; Department of Biomedicine, Siberian State Medical University, 634055 Tomsk, Russia., Vasilieva AR; Department of Biomedicine, Siberian State Medical University, 634055 Tomsk, Russia., Ivanova SA; Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634014 Tomsk, Russia.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2022 Jul 02; Vol. 23 (13). Date of Electronic Publication: 2022 Jul 02.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Antibodies, Catalytic*/chemistry , Bipolar Disorder* , Multiple Sclerosis*/metabolism, Humans ; Immunoglobulin G ; Myelin Basic Protein/metabolism
مستخلص: The pathogenesis of bipolar affective disorder is associated with immunological imbalances, a general pro-inflammatory status, neuroinflammation, and impaired white matter integrity. Myelin basic protein (MBP) is one of the major proteins in the myelin sheath of brain oligodendrocytes. For the first time, we have shown that IgGs isolated from sera of bipolar patients can effectively hydrolyze human myelin basic protein (MBP), unlike other test proteins. Several stringent criteria were applied to assign the studied activity to serum IgG. The level of MBP-hydrolyzing activity of IgG from patients with bipolar disorder was statistically significantly 1.6-folds higher than that of healthy individuals. This article presents a detailed characterization of the catalytic properties of MBP-hydrolyzing antibodies in bipolar disorder, including the substrate specificity, inhibitory analysis, pH dependence of hydrolysis, and kinetic parameters of IgG-dependent MBP hydrolysis, providing the heterogeneity of polyclonal MBP-hydrolyzing IgGs and their difference from canonical proteases. The ability of serum IgG to hydrolyze MBP in bipolar disorder may become an additional link between the processes of myelin damage and inflammation.
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معلومات مُعتمدة: 21-75-00071 Russian Science Foundation
فهرسة مساهمة: Keywords: abzymes; antibodies; bipolar disorder; catalytic IgG; humoral immunity; myelin; myelin basic protein
المشرفين على المادة: 0 (Antibodies, Catalytic)
0 (Immunoglobulin G)
0 (Myelin Basic Protein)
تواريخ الأحداث: Date Created: 20220709 Date Completed: 20220712 Latest Revision: 20220716
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9267049
DOI: 10.3390/ijms23137397
PMID: 35806400
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms23137397