دورية أكاديمية
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Regulation of VEGFA , KRAS , and NFE2L2 Oncogenes by MicroRNAs in Head and Neck Cancer.

التفاصيل البيبلوغرافية
العنوان: Regulation of VEGFA , KRAS , and NFE2L2 Oncogenes by MicroRNAs in Head and Neck Cancer.
المؤلفون: Cuzziol CI; Research Unit of Genetics and Molecular Biology (UPGEM), Department of Molecular Biology, Faculty of Medicine of Sao Jose do Rio Preto (FAMERP), Sao Jose do Rio Preto 15090-000, Brazil., Marzochi LL; Research Unit of Genetics and Molecular Biology (UPGEM), Department of Molecular Biology, Faculty of Medicine of Sao Jose do Rio Preto (FAMERP), Sao Jose do Rio Preto 15090-000, Brazil., Possebon VS; Institute of Biosciences, Humanities and Exact Sciences, Campus Sao Jose do Rio Preto, São Paulo State University (Unesp), Sao Jose do Rio Preto 15054-000, Brazil., Kawasaki-Oyama RS; Research Unit of Genetics and Molecular Biology (UPGEM), Department of Molecular Biology, Faculty of Medicine of Sao Jose do Rio Preto (FAMERP), Sao Jose do Rio Preto 15090-000, Brazil., Mattos MF; Research Unit of Genetics and Molecular Biology (UPGEM), Department of Molecular Biology, Faculty of Medicine of Sao Jose do Rio Preto (FAMERP), Sao Jose do Rio Preto 15090-000, Brazil., Junior VS; Institute of Biosciences, Humanities and Exact Sciences, Campus Sao Jose do Rio Preto, São Paulo State University (Unesp), Sao Jose do Rio Preto 15054-000, Brazil., Ferreira LAM; Research Unit of Genetics and Molecular Biology (UPGEM), Department of Molecular Biology, Faculty of Medicine of Sao Jose do Rio Preto (FAMERP), Sao Jose do Rio Preto 15090-000, Brazil., Pavarino ÉC; Research Unit of Genetics and Molecular Biology (UPGEM), Department of Molecular Biology, Faculty of Medicine of Sao Jose do Rio Preto (FAMERP), Sao Jose do Rio Preto 15090-000, Brazil., Castanhole-Nunes MMU; Research Unit of Genetics and Molecular Biology (UPGEM), Department of Molecular Biology, Faculty of Medicine of Sao Jose do Rio Preto (FAMERP), Sao Jose do Rio Preto 15090-000, Brazil., Goloni-Bertollo EM; Research Unit of Genetics and Molecular Biology (UPGEM), Department of Molecular Biology, Faculty of Medicine of Sao Jose do Rio Preto (FAMERP), Sao Jose do Rio Preto 15090-000, Brazil.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2022 Jul 05; Vol. 23 (13). Date of Electronic Publication: 2022 Jul 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Head and Neck Neoplasms*/genetics , MicroRNAs*/genetics , MicroRNAs*/metabolism , NF-E2-Related Factor 2*/genetics , NF-E2-Related Factor 2*/metabolism , Proto-Oncogene Proteins p21(ras)*/genetics , Proto-Oncogene Proteins p21(ras)*/metabolism , Vascular Endothelial Growth Factor A*/genetics , Vascular Endothelial Growth Factor A*/metabolism, Down-Regulation ; Gene Expression Regulation, Neoplastic ; Humans ; Oncogenes
مستخلص: Mutations and alterations in the expression of VEGFA , KRAS , and NFE2L2 oncogenes play a key role in cancer initiation and progression. These genes are enrolled not only in cell proliferation control, but also in angiogenesis, drug resistance, metastasis, and survival of tumor cells. MicroRNAs (miRNAs) are small, non-coding regulatory RNA molecules that can regulate post-transcriptional expression of multiple target genes. We aimed to investigate if miRNAs hsa-miR-17-5p, hsa-miR-140-5p, and hsa-miR-874-3p could interfere in VEGFA , KRAS , and NFE2L2 expression in cell lines derived from head and neck cancer (HNC). FADU (pharyngeal cancer) and HN13 (oral cavity cancer) cell lines were transfected with miR-17-5p, miR-140-5p, and miR-874-3p microRNA mimics. RNA and protein expression analyses revealed that miR-17-5p, miR-140-5p and miR-874-3p overexpression led to a downregulation of VEGFA , KRAS , and NFE2L2 gene expression in both cell lines analyzed. Taken together, our results provide evidence for the establishment of new biomarkers in the diagnosis and treatment of HNC.
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معلومات مُعتمدة: #2018/26166-6 São Paulo Research Foundation; #2020/03209-1 São Paulo Research Foundation; #2015/04403-8 São Paulo Research Foundation; 001 Coordenação de Aperfeicoamento de Pessoal de Nível Superior; 310987 / 2018-0 National Council for Scientific and Technological Development
فهرسة مساهمة: Keywords: angiogenesis; miR-140-5p; miR-17-5p; miR-874-3p
المشرفين على المادة: 0 (KRAS protein, human)
0 (MIRN874 microRNA, human)
0 (MicroRNAs)
0 (Mirn140 microRNA, human)
0 (NF-E2-Related Factor 2)
0 (NFE2L2 protein, human)
0 (VEGFA protein, human)
0 (Vascular Endothelial Growth Factor A)
EC 3.6.5.2 (Proto-Oncogene Proteins p21(ras))
تواريخ الأحداث: Date Created: 20220709 Date Completed: 20220712 Latest Revision: 20230916
رمز التحديث: 20230916
مُعرف محوري في PubMed: PMC9267745
DOI: 10.3390/ijms23137483
PMID: 35806488
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms23137483