دورية أكاديمية
أعرض في EDS

The Severity of Acute Kidney and Lung Injuries Induced by Cecal Ligation and Puncture Is Attenuated by Menthol: Role of Proliferating Cell Nuclear Antigen and Apoptotic Markers.

التفاصيل البيبلوغرافية
العنوان: The Severity of Acute Kidney and Lung Injuries Induced by Cecal Ligation and Puncture Is Attenuated by Menthol: Role of Proliferating Cell Nuclear Antigen and Apoptotic Markers.
المؤلفون: Anter A; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, Minya, Egypt., Ahmed AF; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, Minya, Egypt., Hammad ASA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, Minya, Egypt., Almalki WH; Department of Pharmacology and Toxicology, Umm Al-Qura University, Makkah, Saudi Arabia., Abdel Hafez SMN; Department of Histology and Cell Biology, Faculty of Medicine, Minia University, Minya, Egypt., Kasem AW; Department of Pathology, Faculty of Medicine, Minia University, Minya, Egypt., El-Moselhy MA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, Minya, Egypt.; Department of Clinical Pharmacy and Pharmacology, Ibn Sina National College for Medical Studies, Jeddah, Saudi Arabia., Alrabia MW; Department of Microbiology and Medical Parasitology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia., Ibrahim ARN; Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.; Department of Biochemistry, Faculty of Pharmacy, Minia University, Minya, Egypt., El-Daly M; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, Minya, Egypt.
المصدر: Frontiers in medicine [Front Med (Lausanne)] 2022 Jun 23; Vol. 9, pp. 904286. Date of Electronic Publication: 2022 Jun 23 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101648047 Publication Model: eCollection Cited Medium: Print ISSN: 2296-858X (Print) Linking ISSN: 2296858X NLM ISO Abbreviation: Front Med (Lausanne) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne, Switzerland : Frontiers Media S.A., [2014]-
مستخلص: Objective: Sepsis-induced acute lung injury (ALI) and acute kidney injury (AKI) are major causes of mortality. Menthol is a natural compound that has anti-inflammatory and antioxidative actions. Since exaggerated inflammatory and oxidative stress are characteristics of sepsis, the aim of this study was to evaluate the effect of menthol against sepsis-induced mortality, ALI, and AKI.
Methods: The cecal ligation and puncture (CLP) procedure was employed as a model of sepsis. Rats were grouped into sham, sham-Menthol, CLP, and CLP-Menthol (100 mg/kg, p.o).
Key Findings: A survival study showed that menthol enhanced the survival after sepsis from 0% in septic group to 30%. Septic rats developed histological evidence of ALI and AKI. Menthol markedly suppressed sepsis induced elevation of tissue TNF-a, ameliorated sepsis-induced cleavage of caspase-3 and restored the antiapoptotic marker Bcl2.
Significance: We introduced a role of the proliferating cell nuclear antigen (PCNA) in these tissues with a possible link to the damage induced by sepsis. PCNA level was markedly reduced in septic animals and menthol ameliorated this effect. Our data provide novel evidence that menthol protects against organ damage and decreases mortality in experimental sepsis.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Anter, Ahmed, Hammad, Almalki, Abdel Hafez, Kasem, El-Moselhy, Alrabia, Ibrahim and El-Daly.)
التعليقات: Erratum in: Front Med (Lausanne). 2022 Sep 22;9:1024554. (PMID: 36213667)
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فهرسة مساهمة: Keywords: AKI; ALI; PCNA; cecal ligation and puncture; menthol
تواريخ الأحداث: Date Created: 20220711 Latest Revision: 20230328
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9260148
DOI: 10.3389/fmed.2022.904286
PMID: 35814769
قاعدة البيانات: MEDLINE
الوصف
تدمد:2296-858X
DOI:10.3389/fmed.2022.904286