دورية أكاديمية
Stromal CD10 expression in gastric adenocarcinoma.
| العنوان: | Stromal CD10 expression in gastric adenocarcinoma. |
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| المؤلفون: | Aziz SJ; Department of Histopathology, Rizgary Teaching Hospital, Erbil, Iraq., Jalal JA; Department of Basic Sciences/Pathology, College of Medicine, Hawler Medical University, Erbil, Iraq., Hamadameen KS; Department of Histopathology, Rizgary Teaching Hospital, Erbil, Iraq. |
| المصدر: | Journal of medicine and life [J Med Life] 2022 May; Vol. 15 (5), pp. 679-684. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: |
| أسماء مطبوعة: | Original Publication: Bucharest : "Carol Davila" University Press |
| مواضيع طبية MeSH: | Adenocarcinoma* , Stomach Neoplasms*, Biomarkers, Tumor/metabolism ; Humans ; Immunohistochemistry ; Neprilysin/metabolism ; Retrospective Studies |
| مستخلص: | Gastric adenocarcinoma is a malignant neoplasm of the gastric mucosa composed of neoplastic cells and supporting stroma as with any neoplasm. Stromal myofibroblasts have an essential role in creating the tumor-promoting environment. They express certain substances, such as CD10. In this study, stromal CD10 expression was investigated by immunohistochemistry in gastric carcinoma, and its association with specific clinicopathological parameters was analyzed. Formalin-fixed paraffin-embedded blocks of 80 gastric adenocarcinoma cases were collected retrospectively in a private laboratory of the Rizgary Teaching Hospital for 2 years (January 2018-January 2020). Finally, the immunohistochemical study of CD10 expression in stromal cells was performed. According to the results, stromal CD10 immunoreactivity was detected in 15% of the cases. Furthermore, a statistically significant correlation was observed between stromal CD10 and the tumor type (P=0.015). However, no statistically significant relationship was identified between stromal CD10 expression and patients' age, gender, lymphovascular invasion, lymph node status, and tumor stage and grade. The results suggest a statistically significant positive correlation between stromal CD10 expression and tumor type. (© 2022 JOURNAL of MEDICINE and LIFE.) |
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| فهرسة مساهمة: | Keywords: gastric adenocarcinoma; immunohistochemistry; stromal CD10; stromal myofibroblasts |
| المشرفين على المادة: | 0 (Biomarkers, Tumor) EC 3.4.24.11 (Neprilysin) |
| تواريخ الأحداث: | Date Created: 20220711 Date Completed: 20220712 Latest Revision: 20220716 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC9262272 |
| DOI: | 10.25122/jml-2021-0244 |
| PMID: | 35815076 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1844-3117 |
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| DOI: | 10.25122/jml-2021-0244 |