دورية أكاديمية
Chronic intracerebroventricular infusion of angiotensin II causes dose- and sex-dependent effects on intake behaviors and energy homeostasis in C57BL/6J mice.
| العنوان: | Chronic intracerebroventricular infusion of angiotensin II causes dose- and sex-dependent effects on intake behaviors and energy homeostasis in C57BL/6J mice. |
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| المؤلفون: | Oliveira V; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin., Reho JJ; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.; Comprehensive Rodent Metabolic Phenotyping Core, Medical College of Wisconsin, Milwaukee, Wisconsin., Balapattabi K; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin., Ritter ML; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin., Mathieu NM; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin., Opichka MA; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin., Lu KT; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin., Grobe CC; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin., Silva SD Jr; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin., Wackman KK; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin., Nakagawa P; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.; Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin., Segar JL; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin.; Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin., Sigmund CD; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.; Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin.; Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin., Grobe JL; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.; Comprehensive Rodent Metabolic Phenotyping Core, Medical College of Wisconsin, Milwaukee, Wisconsin.; Cardiovascular Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin.; Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin.; Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, Wisconsin. |
| المصدر: | American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2022 Oct 01; Vol. 323 (4), pp. R410-R421. Date of Electronic Publication: 2022 Jul 11. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1490 (Electronic) Linking ISSN: 03636119 NLM ISO Abbreviation: Am J Physiol Regul Integr Comp Physiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bethesda, Md. : American Physiological Society |
| مواضيع طبية MeSH: | Angiotensin II*/pharmacology, Animals ; Blood Pressure/physiology ; Female ; Homeostasis ; Infusions, Intraventricular ; Injections, Intraventricular ; Male ; Mice ; Mice, Inbred C57BL |
| مستخلص: | The renin-angiotensin system (RAS) within the brain is implicated in the control of fluid and electrolyte balance, autonomic functions, blood pressure, and energy expenditure. Mouse models are increasingly used to explore these mechanisms; however, sex and dose dependencies of effects elicited by chronic intracerebroventricular (ICV) angiotensin II (ANG II) infusion have not been carefully established in this species. To examine the interactions among sex, body mass, and ICV ANG II on ingestive behaviors and energy balance, young adult C57BL/6J mice of both sexes were studied in a multiplexed metabolic phenotyping system (Promethion) during chronic infusion of ANG II (0, 5, 20, or 50 ng/h). At these infusion rates, ANG II caused accelerating dose-dependent increases in drinking and total energy expenditure in male mice, but female mice exhibited a complex biphasic response with maximum responses at 5 ng/h. Body mass differences did not account for sex-dependent differences in drinking behavior or total energy expenditure. In contrast, resting metabolic rate was similarly increased by ICV ANG II in a dose-dependent manner in both sexes after correction for body mass. We conclude that chronic ICV ANG II stimulates water intake, resting, and total energy expenditure in male C57BL/6J mice following straightforward accelerating dose-dependent kinetics, but female C57BL/6J mice exhibit complex biphasic responses to ICV ANG II. Furthermore, control of resting metabolic rate by ANG II is dissociable from mechanisms controlling fluid intake and total energy expenditure. Future studies of the sex dependency of ANG II within the brain of mice must be designed to carefully consider the biphasic responses that occur in females. |
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| معلومات مُعتمدة: | K01 HL153101 United States HL NHLBI NIH HHS; R01 HL134850 United States HL NHLBI NIH HHS; R35 HL144807 United States HL NHLBI NIH HHS; P01 HL084207 United States HL NHLBI NIH HHS; UL1 TR001436 United States TR NCATS NIH HHS; R01 DK133121 United States DK NIDDK NIH HHS |
| فهرسة مساهمة: | Keywords: angiotensin; brain; drinking; metabolism; sex |
| المشرفين على المادة: | 11128-99-7 (Angiotensin II) |
| تواريخ الأحداث: | Date Created: 20220711 Date Completed: 20220923 Latest Revision: 20231002 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9512112 |
| DOI: | 10.1152/ajpregu.00091.2022 |
| PMID: | 35816717 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1522-1490 |
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| DOI: | 10.1152/ajpregu.00091.2022 |