دورية أكاديمية
أعرض في EDS

Genomic Surveillance of SARS-CoV-2 in a University Community: Insights Into Tracking Variants, Transmission, and Spread of Gamma (P.1) Variant.

التفاصيل البيبلوغرافية
العنوان: Genomic Surveillance of SARS-CoV-2 in a University Community: Insights Into Tracking Variants, Transmission, and Spread of Gamma (P.1) Variant.
المؤلفون: Ciubotariu II; Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA., Dorman J; Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA., Perry NM; Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA., Gorenstein L; Information Technology Research Computing, Purdue University, West Lafayette, Indiana, USA., Kattoor JJ; Department of Comparative Biology, Animal Disease Diagnostic Laboratory, Purdue University College of Veterinary Medicine, West Lafayette, Indiana, USA., Fola AA; Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA., Zine A; Department of Anthropology, University of Iowa, Iowa City, Iowa, USA., Hendrix GK; Department of Comparative Biology, Animal Disease Diagnostic Laboratory, Purdue University College of Veterinary Medicine, West Lafayette, Indiana, USA., Wilkes RP; Department of Comparative Biology, Animal Disease Diagnostic Laboratory, Purdue University College of Veterinary Medicine, West Lafayette, Indiana, USA., Kitchen A; Department of Anthropology, University of Iowa, Iowa City, Iowa, USA., Carpi G; Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA.
المصدر: Open forum infectious diseases [Open Forum Infect Dis] 2022 May 26; Vol. 9 (7), pp. ofac268. Date of Electronic Publication: 2022 May 26 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Published by Oxford University Press on behalf of the Infectious Diseases Society of America Country of Publication: United States NLM ID: 101637045 Publication Model: eCollection Cited Medium: Print ISSN: 2328-8957 (Print) Linking ISSN: 23288957 NLM ISO Abbreviation: Open Forum Infect Dis Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Cary, NC : Published by Oxford University Press on behalf of the Infectious Diseases Society of America, [2014]-
مستخلص: Background: Using a combination of data from routine surveillance, genomic sequencing, and phylogeographic analysis, we tracked the spread and introduction events of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants focusing on a large university community.
Methods: Here, we sequenced and analyzed 677 high-quality SARS-CoV-2 genomes from positive RNA samples collected from Purdue University students, faculty, and staff who tested positive for the virus between January 2021 and May 2021, comprising an average of 32% of weekly cases across the time frame.
Results: Our analysis of circulating SARS-CoV-2 variants over time revealed periods when variants of concern (VOC) Alpha (B.1.1.7) and Iota (B.1.526) reached rapid dominance and documented that VOC Gamma (P.1) was increasing in frequency as campus surveillance was ending. Phylodynamic analysis of Gamma genomes from campus alongside a subsampling of >20 000 previously published P.1 genomes revealed 10 independent introductions of this variant into the Purdue community, predominantly from elsewhere in the United States, with introductions from within the state of Indiana and from Illinois, and possibly Washington and New York, suggesting a degree of domestic spread.
Conclusions: We conclude that a robust and sustained active and passive surveillance program coupled with genomic sequencing during a pandemic offers important insights into the dynamics of pathogen arrival and spread in a campus community and can help guide mitigation measures.
(© The Author(s) 2022. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.)
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فهرسة مساهمة: Keywords: COVID-19 testing; SARS-CoV-2; phylodynamic analysis; university transmission; whole-genome sequencing
تواريخ الأحداث: Date Created: 20220712 Latest Revision: 20220801
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9213861
DOI: 10.1093/ofid/ofac268
PMID: 35818365
قاعدة البيانات: MEDLINE
الوصف
تدمد:2328-8957
DOI:10.1093/ofid/ofac268