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Concurrent anxiety in patients with major depression and cerebral serotonin 4 receptor binding. A NeuroPharm-1 study.

التفاصيل البيبلوغرافية
العنوان: Concurrent anxiety in patients with major depression and cerebral serotonin 4 receptor binding. A NeuroPharm-1 study.
المؤلفون: Köhler-Forsberg K; Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen, Denmark., Ozenne B; Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Department of Public Health, Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark., Larsen SV; Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Poulsen AS; Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Landman EB; Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Dam VH; Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Ip CT; Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Pharmacology, H. Lundbeck A/S, Valby, Denmark., Jørgensen A; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen, Denmark., Svarer C; Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Knudsen GM; Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Frokjaer VG; Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen, Denmark., Jørgensen MB; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. martin.balslev.joergensen@regionh.dk.; Psychiatric Centre Copenhagen, Rigshospitalet, Copenhagen, Denmark. martin.balslev.joergensen@regionh.dk.
المصدر: Translational psychiatry [Transl Psychiatry] 2022 Jul 11; Vol. 12 (1), pp. 273. Date of Electronic Publication: 2022 Jul 11.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Nature Pub. Group
مواضيع طبية MeSH: Anxiety*/diagnosis , Anxiety*/metabolism , Depressive Disorder, Major*/diagnosis , Depressive Disorder, Major*/metabolism , Receptors, Serotonin, 5-HT4*/metabolism, Anxiety Disorders/diagnosis ; Anxiety Disorders/metabolism ; Cerebral Cortex/metabolism ; Depression/diagnostic imaging ; Depression/metabolism ; Humans ; Serotonin/metabolism ; Syndrome
مستخلص: Concurrent anxiety is frequent in major depressive disorder and a shared pathophysiological mechanism between anxiety and other depressive symptoms is plausible. The serotonin 4 receptor (5-HT 4 R) has been implicated in both depression and anxiety. This is the first study to investigate the association between the cerebral 5-HT 4 R binding and anxiety in patients with depression before and after antidepressant treatment and the association to treatment response. Ninety-one drug-free patients with depression were positron emission tomography scanned with the 5-HT 4 R ligand [ 11 C]-SB207145. Depression severity and concurrent anxiety was measured at baseline and throughout 8 weeks of antidepressant treatment. Anxiety measures included four domains: anxiety/somatization factor score; Generalized Anxiety Disorder 10-items (GAD-10) score; anxiety/somatization factor score ≥7 (anxious depression) and syndromal anxious depression. Forty patients were rescanned at week 8. At baseline, we found a negative association between global 5-HT 4 R binding and both GAD-10 score (p < 0.01) and anxiety/somatization factor score (p = 0.06). Further, remitters had a higher baseline anxiety/somatization factor score compared with non-responders (p = 0.04). At rescan, patients with syndromal anxious depression had a greater change in binding relative to patients with non-syndromal depression (p = 0.04). Concurrent anxiety in patients with depression measured by GAD-10 score and anxiety/somatization factor score is negatively associated with cerebral 5-HT 4 R binding. A lower binding may represent a subtype with reduced natural resilience against anxiety in a depressed state, and concurrent anxiety may influence the effect on the 5-HT 4 R from serotonergic antidepressants. The 5-HT 4 R is a promising neuroreceptor for further understanding the underpinnings of concurrent anxiety in patients with depression.
(© 2022. The Author(s).)
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المشرفين على المادة: 158165-40-3 (Receptors, Serotonin, 5-HT4)
333DO1RDJY (Serotonin)
تواريخ الأحداث: Date Created: 20220712 Date Completed: 20220714 Latest Revision: 20220801
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9276803
DOI: 10.1038/s41398-022-02034-5
PMID: 35821015
قاعدة البيانات: MEDLINE
الوصف
تدمد:2158-3188
DOI:10.1038/s41398-022-02034-5